• Gene id: 57140

Gene Summary

• Gene Symbol: RNPEPL1   Gene   UCSC   Ensembl
• Gene name: arginyl aminopeptidase like 1
• Alternate names: aminopeptidase RNPEPL1, RNPEP-like 1, aminopeptidase B-like 1, argininyl aminopeptidase-like 1, arginyl aminopeptidase (aminopeptidase B)-like 1, methionyl aminopeptidase,
• Gene location: 2q37.3 (240568483: 240581371)     Exons: 11     NC_000002.12
• OMIM: 164175

Protein Summary

• Protein general information: Q9HAU8  
  • Name: Aminopeptidase RNPEPL1 (EC 3.4.11. ) (Arginyl aminopeptidase like 1) (Methionyl aminopeptidase) (EC 3.4.11.18)
  • Length: 725  
  • Mass: 80000
  • Tissue specificity: Ubiquitously expressed. Expressed at relatively higher levels in heart and skeletal muscle. {ECO
• Sequence:

  MAAQCCCRQAPGAEAAPVRPPPEPPPALDVASASSAQLFRLRHLQLGLELRPEARELAGCLVLELCALRPAPRAL
  VLDAHPALRLHSAAFRRAPAAAAETPCAFAFSAPGPGPAPPPPLPAFPEAPGSEPACCPLAFRVDPFTDYGSSLT
  VTLPPELQAHQPFQVILRYTSTDAPAIWWLDPELTYGCAKPFVFTQGHSVCNRSFFPCFDTPAVKCTYSAVVKAP
  SGVQVLMSATRSAYMEEEGVFHFHMEHPVPAYLVALVAGDLKPADIGPRSRVWAEPCLLPTATSKLSGAVEQWLS
  AAERLYGPYMWGRYDIVFLPPSFPIVAMENPCLTFIISSILESDEFLVIDVIHEVAHSWFGNAVTNATWEEMWLS
  EGLATYAQRRITTETYGAAFTCLETAFRLDALHRQMKLLGEDSPVSKLQVKLEPGVNPSHLMNLFTYEKGYCFVY
  YLSQLCGDPQRFDDFLRAYVEKYKFTSVVAQDLLDSFLSFFPELKEQSVDCRAGLEFERWLNATGPPLAEPDLSQ
  GSSLTRPVEALFQLWTAEPLDQAAASASAIDISKWRTFQTALFLDRLLDGSPLPQEVVMSLSKCYSSLLDSMNAE
  IRIRWLQIVVRNDYYPDLHRVRRFLESQMSRMYTIPLYEDLCTGALKSFALEVFYQTQGRLHPNLRRAIQQILSQ
  GLGSSTEPASEPSTELGKAEADTDSDAQALLLGDEAPSSAISLRDVNVSA

• Structural information:
  • Interpro: IPR042097  IPR016024  IPR038502  IPR034015  IPR001930   IPR015211  IPR014782  IPR027268  IPR033525  
  • CDD: cd09599
  • STRING: ENSP00000270357
• Other Databases: GeneCards:  RNPEPL1  Malacards:  RNPEPL1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006508	proteolysis	IDA	biological process
GO:0070006	metalloaminopeptidase activity	IDA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0008270	zinc ion binding	IEA	molecular function
GO:0070006	metalloaminopeptidase activity	IEA	molecular function
GO:0008237	metallopeptidase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0004177	aminopeptidase activity	IEA	molecular function
GO:0008233	peptidase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0008237	metallopeptidase activity	IEA	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray