• Gene id: 57097

Gene Summary

• Gene Symbol: PARP11   Gene   UCSC   Ensembl
• Aliases: ARTD11, C12orf6, MIB006
• Gene name: poly(ADP-ribose) polymerase family member 11
• Alternate names: protein mono-ADP-ribosyltransferase PARP11, ADP-ribosyltransferase diphtheria toxin-like 11, poly [ADP-ribose] polymerase 11,
• Gene location: 12p13.32 (3873470: 3808860)     Exons: 12     NC_000012.12
• OMIM: 605878

Protein Summary

• Protein general information: Q9NR21  
  • Name: Protein mono ADP ribosyltransferase PARP11 (EC 2.4.2. ) (ADP ribosyltransferase diphtheria toxin like 11) (ARTD11) (Poly [ADP ribose] polymerase 11) (PARP 11)
  • Length: 338  
  • Mass: 39597
• Sequence:

  MWEANPEMFHKAEELFSKTTNNEVDDMDTSDTQWGWFYLAECGKWHMFQPDTNSQCSVSSEDIEKSFKTNPCGSI
  SFTTSKFSYKIDFAEMKQMNLTTGKQRLIKRAPFSISAFSYICENEAIPMPPHWENVNTQVPYQLIPLHNQTHEY
  NEVANLFGKTMDRNRIKRIQRIQNLDLWEFFCRKKAQLKKKRGVPQINEQMLFHGTSSEFVEAICIHNFDWRING
  IHGAVFGKGTYFARDAAYSSRFCKDDIKHGNTFQIHGVSLQQRHLFRTYKSMFLARVLIGDYINGDSKYMRPPSK
  DGSYVNLYDSCVDDTWNPKIFVVFDANQIYPEYLIDFH

• Structural information:
  • Protein Domains: (22..10-)
    (/note="WWE-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00248-)
    (123..33-)
    (/note="PARP-catalytic)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00397"-)
  • Interpro: IPR012317  IPR004170  IPR037197  
  • Prosite: PS51059 PS50918
  • PDB: 2DK6
  • PDBsum: 2DK6
  • STRING: ENSP00000228820
• Other Databases: GeneCards:  PARP11  Malacards:  PARP11

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0140289	protein mono-ADP-ribosylation	IDA	biological process
GO:1990404	protein ADP-ribosylase activity	IDA	molecular function
GO:0070213	protein auto-ADP-ribosylation	IDA	biological process
GO:0003950	NAD+ ADP-ribosyltransferase activity	IEA	molecular function
GO:0051028	mRNA transport	IEA	biological process
GO:0007283	spermatogenesis	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0005643	nuclear pore	IEA	cellular component
GO:0030154	cell differentiation	IEA	biological process
GO:0016757	transferase activity, transferring glycosyl groups	IEA	molecular function
GO:0015031	protein transport	IEA	biological process
GO:0015031	protein transport	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005635	nuclear envelope	IDA	cellular component
GO:0003950	NAD+ ADP-ribosyltransferase activity	IDA	molecular function
GO:0006998	nuclear envelope organization	IEA	biological process
GO:0005643	nuclear pore	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0016604	nuclear body	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray