• Gene id: 57092

Gene Summary

• Gene Symbol: PCNP   Gene   UCSC   Ensembl
• Gene name: PEST proteolytic signal containing nuclear protein
• Alternate names: PEST proteolytic signal-containing nuclear protein, PEST-containing nuclear protein,
• Gene location: 3q12.3 (101574093: 101594464)     Exons: 6     NC_000003.12
• OMIM: 615210

Protein Summary

• Protein general information: Q8WW12  
  • Name: PEST proteolytic signal containing nuclear protein (PCNP) (PEST containing nuclear protein)
  • Length: 178  
  • Mass: 18925
• Sequence:

  MADGKAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTKISKFGFAI
  GSQTTKKASAISIKLGSSKPKETVPTLAPKTLSVAAAFNEDEDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNK
  GKHGFSDNQKLWERNIKSHLGNVHDQDN

• Structural information:
  • Interpro: IPR029169  
  • STRING: ENSP00000265260
• Other Databases: GeneCards:  PCNP  Malacards:  PCNP

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	biological process
GO:0005634	nucleus	IDA	cellular component
GO:0016567	protein ubiquitination	IDA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IBA	cellular component
GO:0016567	protein ubiquitination	IBA	biological process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IBA	biological process
GO:0016567	protein ubiquitination	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0007049	cell cycle	IEA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0016604	nuclear body	IDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881