• Gene id: 57016

Gene Summary

• Gene Symbol: AKR1B10   Gene   UCSC   Ensembl
• Aliases: AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI
• Gene name: aldo-keto reductase family 1 member B10
• Alternate names: aldo-keto reductase family 1 member B10, ARP, SI reductase, aldo-keto reductase family 1, member B10 (aldose reductase), aldo-keto reductase family 1, member B11 (aldose reductase-like), aldose reductase-like 1, aldose reductase-like peptide, aldose reductase-re,
• Gene location: 7q33 (134527566: 134541411)     Exons: 11     NC_000007.14
• Gene summary(Entrez): This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in
• OMIM: 604707

Protein Summary

• Protein general information: O60218  
  • Name: Aldo keto reductase family 1 member B10 (EC 1.1.1.300) (EC 1.1.1.54) (ARL 1) (Aldose reductase like) (Aldose reductase related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase)
  • Length: 316  
  • Mass: 36020
  • Tissue specificity: Found in many tissues. Highly expressed in small intestine, colon and adrenal gland. {ECO
• Sequence:

  MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFI
  VSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVD
  EGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPED
  PSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACN
  VLQSSHLEDYPFNAEY

• Structural information:
  • Interpro: IPR018170  IPR020471  IPR023210  IPR036812  
  • Prosite: PS00798 PS00062 PS00063
  • CDD: cd06660
  • PDB: 1ZUA 4GA8 4GAB 4GQ0 4GQG 4I5X 4ICC 4JIH 4JII 4WEV 4XZL 4XZM 4XZN 5LIK 5LIU 5LIW 5LIX 5LIY 5M2F 5Y7N
  • PDBsum: 1ZUA 4GA8 4GAB 4GQ0 4GQG 4I5X 4ICC 4JIH 4JII 4WEV 4XZL 4XZM 4XZN 5LIK 5LIU 5LIW 5LIX 5LIY 5M2F 5Y7N
  • STRING: ENSP00000352584
• Other Databases: GeneCards:  AKR1B10  Malacards:  AKR1B10

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008106	alcohol dehydrogenase (NADP+) activity	IBA	molecular function
GO:0005829	cytosol	IBA	cellular component
GO:0016491	oxidoreductase activity	IBA	molecular function
GO:0005739	mitochondrion	IBA	cellular component
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	IBA	molecular function
GO:0008106	alcohol dehydrogenase (NADP+) activity	IDA	molecular function
GO:0110095	cellular detoxification of aldehyde	IDA	biological process
GO:0110095	cellular detoxification of aldehyde	IDA	biological process
GO:0001523	retinoid metabolic process	IDA	biological process
GO:0052650	NADP-retinol dehydrogenase activity	IDA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0005764	lysosome	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0047655	allyl-alcohol dehydrogenase activity	IEA	molecular function
GO:0052650	NADP-retinol dehydrogenase activity	IEA	molecular function
GO:0001523	retinoid metabolic process	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005764	lysosome	IEA	cellular component
GO:0042572	retinol metabolic process	IEA	biological process
GO:0016488	farnesol catabolic process	IDA	biological process
GO:0045550	geranylgeranyl reductase activity	IDA	molecular function
GO:0047718	indanol dehydrogenase activity	IDA	molecular function
GO:0001758	retinal dehydrogenase activity	IDA	molecular function
GO:0044597	daunorubicin metabolic process	IMP	biological process
GO:0004033	aldo-keto reductase (NADP) activity	TAS	molecular function
GO:0044598	doxorubicin metabolic process	IMP	biological process

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00561	Glycerolipid metabolism
hsa00040	Pentose and glucuronate interconversions
hsa00051	Fructose and mannose metabolism
hsa00052	Galactose metabolism
hsa00790	Folate biosynthesis

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881