• Gene id: 57001

Gene Summary

• Gene Symbol: SDHAF3   Gene   UCSC   Ensembl
• Aliases: ACN9, DC11, LYRM10, Sdh7
• Gene name: succinate dehydrogenase complex assembly factor 3
• Alternate names: succinate dehydrogenase assembly factor 3, mitochondrial, ACN9 homolog, SDH assembly factor 3, protein ACN9 homolog, mitochondrial,
• Gene location: 7q21.3 (97117697: 97181762)     Exons: 2     NC_000007.14
• OMIM: 615773

Protein Summary

• Protein general information: Q9NRP4  
  • Name: Succinate dehydrogenase assembly factor 3, mitochondrial (SDH assembly factor 3) (SDHAF3)
  • Length: 125  
  • Mass: 14652
• Sequence:

  MPGRHVSRVRALYKRVLQLHRVLPPDLKSLGDQYVKDEFRRHKTVGSDEAQRFLQEWEVYATALLQQANENRQNS
  TGKACFGTFLPEEKLNDFRDEQIGQLQELMQEATKPNRQFSISESMKPKF

• Structural information:
  • Interpro: IPR008381  
  • STRING: ENSP00000414066
• Other Databases: GeneCards:  SDHAF3  Malacards:  SDHAF3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005758	mitochondrial intermembrane space	ISS	cellular component
GO:0034553	mitochondrial respiratory chain complex II assembly	IBA	biological process
GO:0005758	mitochondrial intermembrane space	IBA	cellular component
GO:0006105	succinate metabolic process	IBA	biological process
GO:0034553	mitochondrial respiratory chain complex II assembly	IEA	biological process
GO:0005739	mitochondrion	IEA	cellular component
GO:0005739	mitochondrion	IEA	cellular component
GO:0005759	mitochondrial matrix	IEA	cellular component
GO:0006111	regulation of gluconeogenesis	ISS	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray