• Gene id: 56985

Gene Summary

• Gene Symbol: ADPRM   Gene   UCSC   Ensembl
• Aliases: C17orf48, MDS006, NBLA03831
• Gene name: ADP-ribose/CDP-alcohol diphosphatase, manganese dependent
• Alternate names: manganese-dependent ADP-ribose/CDP-alcohol diphosphatase, ADP-ribose/CDP-alcohol pyrophosphatase, ADPRibase-Mn, CDP-choline phosphohydrolase,
• Gene location: 17p13.1 (10697593: 10711557)     Exons: 4     NC_000017.11
• OMIM: 601817

Protein Summary

• Protein general information: Q3LIE5  
  • Name: Manganese dependent ADP ribose/CDP alcohol diphosphatase (EC 3.6.1.13) (EC 3.6.1.16) (EC 3.6.1.53) (ADPRibase Mn) (CDP choline phosphohydrolase)
  • Length: 342  
  • Mass: 39529
• Sequence:

  MDDKPNPEALSDSSERLFSFGVIADVQFADLEDGFNFQGTRRRYYRHSLLHLQGAIEDWNNESSMPCCVLQLGDI
  IDGYNAQYNASKKSLELVMDMFKRLKVPVHHTWGNHEFYNFSREYLTHSKLNTKFLEDQIVHHPETMPSEDYYAY
  HFVPFPKFRFILLDAYDLSVLGVDQSSPKYEQCMKILREHNPNTELNSPQGLSEPQFVQFNGGFSQEQLNWLNEV
  LTFSDTNQEKVVIVSHLPIYPDASDNVCLAWNYRDALAVIWSHECVVCFFAGHTHDGGYSEDPFGVYHVNLEGVI
  ETAPDSQAFGTVHVYPDKMMLKGRGRVPDRIMNYKKERAFHC

• Structural information:
  • Interpro: IPR004843  IPR029052  IPR041869  
  • CDD: cd07396
  • STRING: ENSP00000369099
• Other Databases: GeneCards:  ADPRM  Malacards:  ADPRM

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008663	2',3'-cyclic-nucleotide 2'-phosphodiesterase activity	IBA	molecular function
GO:0030145	manganese ion binding	IBA	molecular function
GO:0047631	ADP-ribose diphosphatase activity	IBA	molecular function
GO:0047734	CDP-glycerol diphosphatase activity	IBA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0047734	CDP-glycerol diphosphatase activity	IEA	molecular function
GO:0047631	ADP-ribose diphosphatase activity	IEA	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0034656	nucleobase-containing small molecule catabolic process	TAS	biological process
GO:0008663	2',3'-cyclic-nucleotide 2'-phosphodiesterase activity	IBA	molecular function
GO:0030145	manganese ion binding	IBA	molecular function
GO:0047631	ADP-ribose diphosphatase activity	IBA	molecular function
GO:0047734	CDP-glycerol diphosphatase activity	IBA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0047734	CDP-glycerol diphosphatase activity	IEA	molecular function
GO:0047631	ADP-ribose diphosphatase activity	IEA	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0034656	nucleobase-containing small molecule catabolic process	TAS	biological process

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00230	Purine metabolism
hsa00564	Glycerophospholipid metabolism

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881