• Gene id: 5697

Gene Summary

• Gene Symbol: PYY   Gene   UCSC   Ensembl
• Aliases: PYY-I, PYY1
• Gene name: peptide YY
• Alternate names: peptide YY, peptide tyrosine tyrosine, prepro-PYY,
• Gene location: 17q21.31 (44004468: 43952732)     Exons: 7     NC_000017.11
• Gene summary(Entrez): This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrin

Protein Summary

• Protein general information: P10082  
  • Name: Peptide YY (PYY) (PYY I) (Peptide tyrosine tyrosine) [Cleaved into: Peptide YY(3 36) (PYY II)]
  • Length: 97  
  • Mass: 11145
• Sequence:

  MVFVRRPWPALTTVLLALLVCLGALVDAYPIKPEAPREDASPEELNRYYASLRHYLNLVTRQRYGKRDGPDTLLS
  KTFFPDGEDRPVRSRSEGPDLW

• Structural information:
  • Interpro: IPR001955  IPR020392  
  • Prosite: PS00265 PS50276
  • CDD: cd00126
  • PDB: 2DEZ 2DF0 2L60 2NA5
  • PDBsum: 2DEZ 2DF0 2L60 2NA5
  • STRING: ENSP00000353198
• Other Databases: GeneCards:  PYY  Malacards:  PYY

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0007218	neuropeptide signaling pathway	IBA	biological process
GO:0005615	extracellular space	IBA	cellular component
GO:0005184	neuropeptide hormone activity	IBA	molecular function
GO:0001664	G protein-coupled receptor binding	IBA	molecular function
GO:0007631	feeding behavior	IBA	biological process
GO:0005179	hormone activity	IBA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005179	hormone activity	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005179	hormone activity	IEA	molecular function
GO:0005179	hormone activity	TAS	molecular function
GO:0007631	feeding behavior	TAS	biological process
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0001664	G protein-coupled receptor binding	IPI	molecular function
GO:0001664	G protein-coupled receptor binding	IPI	molecular function
GO:0060575	intestinal epithelial cell differentiation	TAS	biological process

KEGG pathways

Pathway id	Pathway name
hsa04080	Neuroactive ligand-receptor interaction

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq