• Gene id: 56950

Gene Summary

• Gene Symbol: SMYD2   Gene   UCSC   Ensembl
• Aliases: HSKM-B, KMT3C, ZMYND14
• Gene name: SET and MYND domain containing 2
• Alternate names: N-lysine methyltransferase SMYD2, SET and MYND domain-containing protein 2, histone methyltransferase SMYD2, lysine N-methyltransferase 3C, zinc finger, MYND domain containing 14,
• Gene location: 1q32.3 (214281158: 214337135)     Exons: 12     NC_000001.11
• Gene summary(Entrez): SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).[supplied by OMIM, Nov 2008]
• OMIM: 605556

Protein Summary

• Protein general information: Q9NRG4  
  • Name: N lysine methyltransferase SMYD2 (EC 2.1.1. ) (HSKM B) (Histone methyltransferase SMYD2) (EC 2.1.1.354) (Lysine N methyltransferase 3C) (SET and MYND domain containing protein 2)
  • Length: 433  
  • Mass: 49688
• Sequence:

  MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKEGLSKCGRCKQAFYCN
  VECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQ
  SDIAALHHFYSKHLGFPDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVR
  AVQEIKPGEEVFTSYIDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARN
  VIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALQYGQKIIKPYSKHYP
  LYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIESH

• Structural information:
  • Protein Domains: (7..24-)
    (/note="SET-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00190"-)
  • Interpro: IPR001214  IPR011990  IPR002893  
  • Prosite: PS50280 PS01360 PS50865
  • PDB: 3RIB 3S7B 3S7D 3S7F 3S7J 3TG4 3TG5 4O6F 4WUY 4YND 5ARF 5ARG 5KJK 5KJL 5KJM 5KJN 5V3H 5WCG 6CBX 6CBY 6MON 6N3G
  • PDBsum: 3RIB 3S7B 3S7D 3S7F 3S7J 3TG4 3TG5 4O6F 4WUY 4YND 5ARF 5ARG 5KJK 5KJL 5KJM 5KJN 5V3H 5WCG 6CBX 6CBY 6MON 6N3G
  • DIP: 50202
  • STRING: ENSP00000355924
• Other Databases: GeneCards:  SMYD2  Malacards:  SMYD2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0018024	histone-lysine N-methyltransferase activity	IBA	molecular function
GO:0034968	histone lysine methylation	IBA	biological process
GO:0005634	nucleus	IBA	cellular component
GO:0018026	peptidyl-lysine monomethylation	IDA	biological process
GO:0018026	peptidyl-lysine monomethylation	IDA	biological process
GO:0016279	protein-lysine N-methyltransferase activity	IDA	molecular function
GO:0016279	protein-lysine N-methyltransferase activity	IDA	molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0046975	histone methyltransferase activity (H3-K36 specific)	ISS	molecular function
GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	IMP	biological process
GO:0018027	peptidyl-lysine dimethylation	ISS	biological process
GO:0008285	negative regulation of cell population proliferation	ISS	biological process
GO:0005829	cytosol	ISS	cellular component
GO:0002039	p53 binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	ISS	cellular component
GO:0005634	nucleus	ISS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0000993	RNA polymerase II complex binding	ISS	molecular function
GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0006325	chromatin organization	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0032259	methylation	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0016278	lysine N-methyltransferase activity	TAS	molecular function
GO:1901796	regulation of signal transduction by p53 class mediator	TAS	biological process
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0000993	RNA polymerase II complex binding	IEA	molecular function
GO:0007507	heart development	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0046975	histone methyltransferase activity (H3-K36 specific)	IEA	molecular function
GO:0018027	peptidyl-lysine dimethylation	IEA	biological process
GO:0016571	histone methylation	IEA	biological process
GO:0008285	negative regulation of cell population proliferation	IEA	biological process
GO:0005829	cytosol	IEA	cellular component
GO:0005829	cytosol	IEA	cellular component
GO:0005829	cytosol	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0010452	histone H3-K36 methylation	IEA	biological process
GO:0010452	histone H3-K36 methylation	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00310	Lysine degradation

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq