• Gene id: 56934

Gene Summary

• Gene Symbol: CA10   Gene   UCSC   Ensembl
• Aliases: CA-RPX, CARPX, HUCEP-15
• Gene name: carbonic anhydrase 10
• Alternate names: carbonic anhydrase-related protein 10, CA-RP X, CARP X, carbonic anhydrase X, carbonic anhydrase-related protein X, cerebral protein-15, epididymis secretory sperm binding protein,
• Gene location: 17q21.33-q22 (52160016: 51630312)     Exons: 12     NC_000017.11
• Gene summary(Entrez): This gene encodes a protein that belongs to the carbonic anhydrase family of zinc metalloenzymes, which catalyze the reversible hydration of carbon dioxide in various biological processes. The protein encoded by this gene is an acatalytic member of the al
• OMIM: 604642

Protein Summary

• Protein general information: Q9NS85  
  • Name: Carbonic anhydrase related protein 10 (Carbonic anhydrase related protein X) (CA RP X) (CARP X) (Cerebral protein 15)
  • Length: 328  
  • Mass: 37563
  • Tissue specificity: Strong expression in brain and central nervous system. {ECO
• Sequence:

  MEIVWEVLFLLQANFIVCISAQQNSPKIHEGWWAYKEVVQGSFVPVPSFWGLVNSAWNLCSVGKRQSPVNIETSH
  MIFDPFLTPLRINTGGRKVSGTMYNTGRHVSLRLDKEHLVNISGGPMTYSHRLEEIRLHFGSEDSQGSEHLLNGQ
  AFSGEVQLIHYNHELYTNVTEAAKSPNGLVVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEEL
  YPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRPVQPLNNRCIRTN
  INFSLQGKDCPNNRAQKLQYRVNEWLLK

• Structural information:
  • Protein Domains: (31..30-)
    (/note="Alpha-carbonic-anhydrase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01134"-)
  • Interpro: IPR041878  IPR018423  IPR001148  IPR036398  IPR023561  
  • Prosite: PS51144
  • CDD: cd03121
  • STRING: ENSP00000405388
• Other Databases: GeneCards:  CA10  Malacards:  CA10

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016836	hydro-lyase activity	IBA	molecular function
GO:0006730	one-carbon metabolic process	IBA	biological process
GO:0008270	zinc ion binding	IEA	molecular function
GO:0004089	carbonate dehydratase activity	IEA	molecular function
GO:0005575	cellular_component	ND	cellular component
GO:0003674	molecular_function	ND	molecular function
GO:0007420	brain development	NAS	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray