About Us

Search Result


Gene id 5692
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary

Gene Symbol PSMB4   Gene   UCSC   Ensembl
Aliases HN3, HsN3, PRAAS3, PROS-26, PROS26
Gene name proteasome 20S subunit beta 4
Alternate names proteasome subunit beta type-4, 26 kDa prosomal protein, hsBPROS26, macropain beta chain, multicatalytic endopeptidase complex beta chain, proteasome (prosome, macropain) subunit, beta type, 4, proteasome beta chain, proteasome chain 3, proteasome subunit HsN3, pr,
Gene location 1q21.3 (162727801: 161347416)     Exons: 14     NC_000006.12
Gene summary(Entrez) The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta
OMIM 602177

Protein Summary

Protein general information P28070  

Name: Proteasome subunit beta type 4 (EC 3.4.25.1) (26 kDa prosomal protein) (HsBPROS26) (PROS 26) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (HsN3)

Length: 264  Mass: 29204

Sequence MEAFLGSRSGLWAGGPAPGQFYRIPSTPDSFMDPASALYRGPITRTQNPMVTGTSVLGVKFEGGVVIAADMLGSY
GSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDEELLGDGHSYSPRAIHSWLTRAMYSRRSKMNP
LWNTMVIGGYADGESFLGYVDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRD
ARSYNRFQIATVTEKGVEIEGPLSTETNWDIAHMISGFE
Structural information
Interpro:  IPR029055  IPR016295  IPR016050  IPR001353  IPR023333  
Prosite:   PS00854 PS51476
CDD:   cd03760

PDB:  
4R3O 4R67 5A0Q 5GJQ 5GJR 5L4G 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFO 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 6AVO 6E5B 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6R70 6REY 6RGQ
PDBsum:   4R3O 4R67 5A0Q 5GJQ 5GJR 5L4G 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFO 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 6AVO 6E5B 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6R70 6REY 6RGQ

DIP:  

33844

MINT:  
STRING:   ENSP00000290541
Other Databases GeneCards:  PSMB4  Malacards:  PSMB4

Gene ontology

Expand All | Collapse All

GO accessionTerm nameEvidence codeGo category
GO:0010498 proteasomal protein catab
olic process
IBA biological process
GO:0010499 proteasomal ubiquitin-ind
ependent protein cataboli
c process
IBA biological process
GO:0004175 endopeptidase activity
IBA molecular function
GO:0005634 nucleus
IBA cellular component
GO:0005737 cytoplasm
IBA cellular component
GO:0005839 proteasome core complex
IBA cellular component
GO:0043161 proteasome-mediated ubiqu
itin-dependent protein ca
tabolic process
IBA biological process
GO:0000502 proteasome complex
IDA cellular component
GO:0019774 proteasome core complex,
beta-subunit complex
ISS cellular component
GO:0005839 proteasome core complex
ISS cellular component
GO:0004298 threonine-type endopeptid
ase activity
IEA molecular function
GO:0051603 proteolysis involved in c
ellular protein catabolic
process
IEA biological process
GO:0004175 endopeptidase activity
IEA molecular function
GO:0005839 proteasome core complex
IEA cellular component
GO:0004298 threonine-type endopeptid
ase activity
IEA molecular function
GO:0008233 peptidase activity
IEA molecular function
GO:0016787 hydrolase activity
IEA molecular function
GO:0006508 proteolysis
IEA biological process
GO:0016032 viral process
IEA biological process
GO:0000502 proteasome complex
IEA cellular component
GO:0005634 nucleus
IEA cellular component
GO:0005737 cytoplasm
IEA cellular component
GO:0000502 proteasome complex
TAS cellular component
GO:0000165 MAPK cascade
TAS biological process
GO:0000209 protein polyubiquitinatio
n
TAS biological process
GO:0006521 regulation of cellular am
ino acid metabolic proces
s
TAS biological process
GO:0010972 negative regulation of G2
/M transition of mitotic
cell cycle
TAS biological process
GO:0016579 protein deubiquitination
TAS biological process
GO:0031145 anaphase-promoting comple
x-dependent catabolic pro
cess
TAS biological process
GO:0031145 anaphase-promoting comple
x-dependent catabolic pro
cess
TAS biological process
GO:0031145 anaphase-promoting comple
x-dependent catabolic pro
cess
TAS biological process
GO:0031146 SCF-dependent proteasomal
ubiquitin-dependent prot
ein catabolic process
TAS biological process
GO:0038061 NIK/NF-kappaB signaling
TAS biological process
GO:0043161 proteasome-mediated ubiqu
itin-dependent protein ca
tabolic process
TAS biological process
GO:0043161 proteasome-mediated ubiqu
itin-dependent protein ca
tabolic process
TAS biological process
GO:0043161 proteasome-mediated ubiqu
itin-dependent protein ca
tabolic process
TAS biological process
GO:0050852 T cell receptor signaling
pathway
TAS biological process
GO:0055085 transmembrane transport
TAS biological process
GO:0060071 Wnt signaling pathway, pl
anar cell polarity pathwa
y
TAS biological process
GO:0070498 interleukin-1-mediated si
gnaling pathway
TAS biological process
GO:0090090 negative regulation of ca
nonical Wnt signaling pat
hway
TAS biological process
GO:0090263 positive regulation of ca
nonical Wnt signaling pat
hway
TAS biological process
GO:0002223 stimulatory C-type lectin
receptor signaling pathw
ay
TAS biological process
GO:0002479 antigen processing and pr
esentation of exogenous p
eptide antigen via MHC cl
ass I, TAP-dependent
TAS biological process
GO:0005654 nucleoplasm
TAS cellular component
GO:0005654 nucleoplasm
TAS cellular component
GO:0005654 nucleoplasm
TAS cellular component
GO:0005654 nucleoplasm
TAS cellular component
GO:0005654 nucleoplasm
TAS cellular component
GO:0005654 nucleoplasm
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0033209 tumor necrosis factor-med
iated signaling pathway
TAS biological process
GO:0038095 Fc-epsilon receptor signa
ling pathway
TAS biological process
GO:0043488 regulation of mRNA stabil
ity
TAS biological process
GO:0043687 post-translational protei
n modification
TAS biological process
GO:0061418 regulation of transcripti
on from RNA polymerase II
promoter in response to
hypoxia
TAS biological process
GO:1901990 regulation of mitotic cel
l cycle phase transition
TAS biological process
GO:1902036 regulation of hematopoiet
ic stem cell differentiat
ion
TAS biological process
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0002862 negative regulation of in
flammatory response to an
tigenic stimulus
IEA biological process
GO:0005839 proteasome core complex
IEA cellular component
GO:0001530 lipopolysaccharide bindin
g
IEA molecular function
GO:0005737 cytoplasm
IEA cellular component
GO:0005634 nucleus
IEA cellular component
GO:0036064 ciliary basal body
IDA cellular component
GO:0000502 proteasome complex
IDA cellular component
GO:0070062 extracellular exosome
HDA cellular component
GO:0005634 nucleus
HDA cellular component
GO:0005515 protein binding
IPI molecular function
GO:0005634 nucleus
TAS cellular component

KEGG pathways

Expand All | Collapse All

Pathway idPathway name
hsa05010Alzheimer disease
hsa05016Huntington disease
hsa05012Parkinson disease
hsa05017Spinocerebellar ataxia
hsa03050Proteasome
Associated diseases References
Teratozoospermia MIK: 17327269

PubMed references

Expand All | Collapse All

PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
17327269 Teratozoos
permia

13 (5 controls,
8 cases)
Male infertility GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
Show abstract