• Gene id: 56903

Gene Summary

• Gene Symbol: PAPOLB   Gene   UCSC   Ensembl
• Aliases: PAPT, TPAP
• Gene name: poly(A) polymerase beta
• Alternate names: poly(A) polymerase beta, PAP-beta, poly(A) polymerase beta (testis specific), polynucleotide adenylyltransferase beta, testis-specific poly(A) polymerase,
• Gene location: 7p22.1 (4862029: 4857737)     Exons: 1     NC_000007.14
• OMIM: 607436

Protein Summary

• Protein general information: Q9NRJ5  
  • Name: Poly(A) polymerase beta (PAP beta) (EC 2.7.7.19) (Polynucleotide adenylyltransferase beta) (Testis specific poly(A) polymerase)
  • Length: 636  
  • Mass: 71681
  • Tissue specificity: Testis specific.
• Sequence:

  MPFPVTTQGPPQPAPPPNRYGVSSPISLAVPKETDCLLTQRLIETLRPFGVFEEEEELQRRILVLEKLNNLVKEW
  IREISESKSLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVAPSHVDRSDFFTSFYAKLKLQEEVKDLRAVE
  EAFVPVIKLCFDGIEIDILFARLALQTIPEDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLR
  AIKLWAKCHNIYSNILGFLGGVSWAMLVARTCQLYPNAVASTLVRKFFLVFSEWEWPNPVLLKEPEERNLNLPVW
  DPRVNPSDRYHLMPIITPAYPQQNSTYNVSISTRMVMIEEFKQGLAITHEILLSKAEWSKLFEAPSFFQKYKHYI
  VLLASASTEKQHLEWVGLVESKIRILVGSLEKNEFITLAHVNPQSFPAPKENPDMEEFRTMWVIGLGLKKPDNSE
  ILSIDLTYDIQSFTDTVYRQAVNSKMFEMGMKITAMHLRRKELHQLLPHHVLQDKKAHSTEGRRLTDLNDSSFDL
  SAGCENSMSVPSSTSTMKTGPLISSSQGRNSPALAVMTASVANIQATEFSLQQVNTNESSGVALNESIPHAVSQP
  AISPSPKAMVARVVSSTCLISHPDLQETQQQTYLIL

• Structural information:
  • Interpro: IPR011068  IPR007012  IPR007010  IPR014492  IPR002934  
  • STRING: ENSP00000384700
• Other Databases: GeneCards:  PAPOLB  Malacards:  PAPOLB

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004652	polynucleotide adenylyltransferase activity	IBA	molecular function
GO:0005634	nucleus	IBA	cellular component
GO:0006378	mRNA polyadenylation	IBA	biological process
GO:0016779	nucleotidyltransferase activity	IEA	molecular function
GO:0031123	RNA 3'-end processing	IEA	biological process
GO:0043631	RNA polyadenylation	IEA	biological process
GO:0003723	RNA binding	IEA	molecular function
GO:0004652	polynucleotide adenylyltransferase activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0016740	transferase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0003723	RNA binding	IEA	molecular function
GO:0006397	mRNA processing	IEA	biological process
GO:0004652	polynucleotide adenylyltransferase activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa03015	mRNA surveillance pathway

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray