• Gene id: 5651

Gene Summary

• Gene Symbol: TMPRSS15   Gene   UCSC   Ensembl
• Aliases: ENTK, PRSS7
• Gene name: transmembrane serine protease 15
• Alternate names: enteropeptidase, enterokinase catalytic subunit, protease, serine, 7 (enterokinase), serine protease 7, transmembrane protease, serine 15,
• Gene location: 21q21.1 (18403805: 18269106)     Exons: 53     NC_000021.9
• Gene summary(Entrez): This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linke
• OMIM: 606635

Protein Summary

• Protein general information: P98073  
  • Name: Enteropeptidase (EC 3.4.21.9) (Enterokinase) (Serine protease 7) (Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non catalytic heavy chain; Enteropeptidase catalytic light chain]
  • Length: 1019  
  • Mass: 112935
  • Tissue specificity: Intestinal brush border.
• Sequence:

  MGSKRGISSRHHSLSSYEIMFAALFAILVVLCAGLIAVSCLTIKESQRGAALGQSHEARATFKITSGVTYNPNLQ
  DKLSVDFKVLAFDLQQMIDEIFLSSNLKNEYKNSRVLQFENGSIIVVFDLFFAQWVSDENVKEELIQGLEANKSS
  QLVTFHIDLNSVDILDKLTTTSHLATPGNVSIECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDEDNKMCATVC
  DGRFLLTGSSGSFQATHYPKPSETSVVCQWIIRVNQGLSIKLSFDDFNTYYTDILDIYEGVGSSKILRASIWETN
  PGTIRIFSNQVTATFLIESDESDYVGFNATYTAFNSSELNNYEKINCNFEDGFCFWVQDLNDDNEWERIQGSTFS
  PFTGPNFDHTFGNASGFYISTPTGPGGRQERVGLLSLPLDPTLEPACLSFWYHMYGENVHKLSINISNDQNMEKT
  VFQKEGNYGDNWNYGQVTLNETVKFKVAFNAFKNKILSDIALDDISLTYGICNGSLYPEPTLVPTPPPELPTDCG
  GPFELWEPNTTFSSTNFPNSYPNLAFCVWILNAQKGKNIQLHFQEFDLENINDVVEIRDGEEADSLLLAVYTGPG
  PVKDVFSTTNRMTVLLITNDVLARGGFKANFTTGYHLGIPEPCKADHFQCKNGECVPLVNLCDGHLHCEDGSDEA
  DCVRFFNGTTNNNGLVRFRIQSIWHTACAENWTTQISNDVCQLLGLGSGNSSKPIFPTDGGPFVKLNTAPDGHLI
  LTPSQQCLQDSLIRLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAH
  CVYGRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEE
  NQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYNITENMICAGYEEGGIDSCQGDSGGPL
  MCQENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQSFLH

• Structural information:
  • Protein Domains: (54..16-)
    (/note="SEA-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00188-)
    (182..22-)
    A (/note="LDL-receptor-class)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00124-)
    (225..33-)
    (/note="CUB-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:-)
  • Interpro: IPR013320  IPR000859  IPR036055  IPR023415  IPR002172   IPR000998  IPR011163  IPR009003  IPR001314  IPR000082  IPR036364  IPR035914  IPR001190  IPR017448  IPR036772  IPR001254  IPR018114  IPR033116  
  • Prosite: PS01180 PS01209 PS50068 PS00740 PS50060 PS50024 PS50287 PS50240 PS00134 PS00135
  • CDD: cd00041 cd00112 cd06263 cd00190
  • PDB: 4DGJ
  • PDBsum: 4DGJ
  • STRING: ENSP00000284885
• Other Databases: GeneCards:  TMPRSS15  Malacards:  TMPRSS15

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016020	membrane	IBA	cellular component
GO:0004252	serine-type endopeptidase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0005044	scavenger receptor activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0008233	peptidase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0008236	serine-type peptidase activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005903	brush border	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0006897	endocytosis	IEA	biological process

Diseases

Associated diseases	References
Enterokinase deficiency	KEGG:H00988
Enterokinase deficiency	KEGG:H00988
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray