• Gene id: 5650

Gene Summary

• Gene Symbol: KLK7   Gene   UCSC   Ensembl
• Aliases: PRSS6, SCCE, hK7
• Gene name: kallikrein related peptidase 7
• Alternate names: kallikrein-7, kallikrein 7 (chymotryptic, stratum corneum), serine protease 6, signal protein, stratum corneum chymotryptic enzyme,
• Gene location: 19q13.41 (50984063: 50976467)     Exons: 7     NC_000019.10
• Gene summary(Entrez): This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the
• OMIM: 142780

Protein Summary

• Protein general information: P49862  
  • Name: Kallikrein 7 (hK7) (EC 3.4.21.117) (Serine protease 6) (Stratum corneum chymotryptic enzyme) (hSCCE)
  • Length: 253  
  • Mass: 27525
  • Tissue specificity: Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, tr
• Sequence:

  MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNE
  YTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWG
  TTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFP
  CGQPNDPGVYTQVCKFTKWINDTMKKHR

• Structural information:
  • Protein Domains: (30..25-)
    (/note="Peptidase-S1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00274"-)
  • Interpro: IPR009003  IPR001314  IPR001254  IPR018114  IPR033116  
  • Prosite: PS50240 PS00134 PS00135
  • CDD: cd00190
  • PDB: 2QXG 2QXH 2QXI 2QXJ 3BSQ 5FAH 5Y9L 5YJK
  • PDBsum: 2QXG 2QXH 2QXI 2QXJ 3BSQ 5FAH 5Y9L 5YJK
  • STRING: ENSP00000375683
• Other Databases: GeneCards:  KLK7  Malacards:  KLK7

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0030141	secretory granule	IBA	cellular component
GO:0002803	positive regulation of antibacterial peptide production	IBA	biological process
GO:0004252	serine-type endopeptidase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0006508	proteolysis	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0016787	hydrolase activity	IEA	molecular function
GO:0008233	peptidase activity	IEA	molecular function
GO:0008236	serine-type peptidase activity	IEA	molecular function
GO:0008236	serine-type peptidase activity	TAS	molecular function
GO:0008544	epidermis development	TAS	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0022617	extracellular matrix disassembly	TAS	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0097209	epidermal lamellar body	IDA	cellular component
GO:0005615	extracellular space	IMP	cellular component
GO:0002803	positive regulation of antibacterial peptide production	IMP	biological process
GO:0008233	peptidase activity	IMP	molecular function

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R