• Gene id: 5641

Gene Summary

• Gene Symbol: LGMN   Gene   UCSC   Ensembl
• Aliases: AEP, LGMN1, PRSC1
• Gene name: legumain
• Alternate names: legumain, asparaginyl endopeptidase, cysteine protease 1, protease, cysteine 1, protease, cysteine, 1 (legumain),
• Gene location: 14q32.12 (92748626: 92703808)     Exons: 18     NC_000014.9
• Gene summary(Entrez): This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal s
• OMIM: 602620

Protein Summary

• Protein general information: Q99538  
  • Name: Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (Protease, cysteine 1)
  • Length: 433  
  • Mass: 49411
  • Tissue specificity: Ubiquitous. Particularly abundant in kidney, heart and placenta.
• Sequence:

  MVWKVAVFLSVALGIGAVPIDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNGIPDEQIVVMMYDDIA
  YSEDNPTPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGDAEAVKGIGSGKVLKSGPQDHVFIYFTDHGS
  TGILVFPNEDLHVKDLNETIHYMYKHKMYRKMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKR
  STYLGDWYSVNWMEDSDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKTISTMKVMQFQGMKRKASSPVPLPPVT
  HLDLTPSPDVPLTIMKRKLMNTNDLEESRQLTEEIQRHLDARHLIEKSVRKIVSLLAASEAEVEQLLSERAPLTG
  HSCYPEALLHFRTHCFNWHSPTYEYALRHLYVLVNLCEKPYPLHRIKLSMDHVCLGHY

• Structural information:
  • Interpro: IPR001096  
  • PDB: 4AW9 4AWA 4AWB 4FGU 4N6N 4N6O 5LU8 5LU9 5LUA 5LUB
  • PDBsum: 4AW9 4AWA 4AWB 4FGU 4N6N 4N6O 5LU8 5LU9 5LUA 5LUB
  • STRING: ENSP00000376911
• Other Databases: GeneCards:  LGMN  Malacards:  LGMN

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004197	cysteine-type endopeptidase activity	IDA	molecular function
GO:0004197	cysteine-type endopeptidase activity	IDA	molecular function
GO:0004197	cysteine-type endopeptidase activity	IDA	molecular function
GO:0004197	cysteine-type endopeptidase activity	IDA	molecular function
GO:1904646	cellular response to amyloid-beta	IDA	biological process
GO:0035729	cellular response to hepatocyte growth factor stimulus	IDA	biological process
GO:2001028	positive regulation of endothelial cell chemotaxis	IDA	biological process
GO:0005576	extracellular region	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0048471	perinuclear region of cytoplasm	IDA	cellular component
GO:0004197	cysteine-type endopeptidase activity	TAS	molecular function
GO:0048156	tau protein binding	NAS	molecular function
GO:0004197	cysteine-type endopeptidase activity	ISS	molecular function
GO:0004197	cysteine-type endopeptidase activity	IMP	molecular function
GO:0004197	cysteine-type endopeptidase activity	ISS	molecular function
GO:0004197	cysteine-type endopeptidase activity	ISS	molecular function
GO:0004197	cysteine-type endopeptidase activity	ISS	molecular function
GO:0010447	response to acidic pH	IDA	biological process
GO:0071277	cellular response to calcium ion	IDA	biological process
GO:0097264	self proteolysis	IDA	biological process
GO:0097264	self proteolysis	IDA	biological process
GO:0006508	proteolysis	ISS	biological process
GO:0007613	memory	ISS	biological process
GO:0008284	positive regulation of cell population proliferation	IMP	biological process
GO:0097202	activation of cysteine-type endopeptidase activity	IDA	biological process
GO:0097202	activation of cysteine-type endopeptidase activity	IDA	biological process
GO:0090026	positive regulation of monocyte chemotaxis	IDA	biological process
GO:0008306	associative learning	ISS	biological process
GO:0005764	lysosome	TAS	cellular component
GO:1900273	positive regulation of long-term synaptic potentiation	ISS	biological process
GO:0010447	response to acidic pH	ISS	biological process
GO:0010447	response to acidic pH	ISS	biological process
GO:0010447	response to acidic pH	ISS	biological process
GO:0045931	positive regulation of mitotic cell cycle	IMP	biological process
GO:0005770	late endosome	TAS	cellular component
GO:0051603	proteolysis involved in cellular protein catabolic process	TAS	biological process
GO:0010629	negative regulation of gene expression	IMP	biological process
GO:0097061	dendritic spine organization	ISS	biological process
GO:0004197	cysteine-type endopeptidase activity	IBA	molecular function
GO:0006624	vacuolar protein processing	IBA	biological process
GO:0051603	proteolysis involved in cellular protein catabolic process	IBA	biological process
GO:1901185	negative regulation of ERBB signaling pathway	ISS	biological process
GO:0051603	proteolysis involved in cellular protein catabolic process	ISS	biological process
GO:0032801	receptor catabolic process	ISS	biological process
GO:0006508	proteolysis	ISS	biological process
GO:0005764	lysosome	ISS	cellular component
GO:0004197	cysteine-type endopeptidase activity	ISS	molecular function
GO:0003014	renal system process	ISS	biological process
GO:0006508	proteolysis	IEA	biological process
GO:0008233	peptidase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0008233	peptidase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0005764	lysosome	IEA	cellular component
GO:0008234	cysteine-type peptidase activity	IEA	molecular function
GO:0008233	peptidase activity	IDA	molecular function
GO:0043524	negative regulation of neuron apoptotic process	IGI	biological process
GO:0043524	negative regulation of neuron apoptotic process	IGI	biological process
GO:0002224	toll-like receptor signaling pathway	TAS	biological process
GO:0004197	cysteine-type endopeptidase activity	TAS	molecular function
GO:0004197	cysteine-type endopeptidase activity	TAS	molecular function
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	TAS	biological process
GO:0036021	endolysosome lumen	TAS	cellular component
GO:0043202	lysosomal lumen	TAS	cellular component
GO:0043202	lysosomal lumen	TAS	cellular component
GO:0042359	vitamin D metabolic process	TAS	biological process
GO:1900273	positive regulation of long-term synaptic potentiation	IEA	biological process
GO:0040015	negative regulation of multicellular organism growth	IEA	biological process
GO:0008306	associative learning	IEA	biological process
GO:0005770	late endosome	IEA	cellular component
GO:0004197	cysteine-type endopeptidase activity	IEA	molecular function
GO:0003014	renal system process	IEA	biological process
GO:1901185	negative regulation of ERBB signaling pathway	IEA	biological process
GO:0097061	dendritic spine organization	IEA	biological process
GO:0051603	proteolysis involved in cellular protein catabolic process	IEA	biological process
GO:0045177	apical part of cell	IEA	cellular component
GO:0032801	receptor catabolic process	IEA	biological process
GO:0010447	response to acidic pH	IEA	biological process
GO:0008233	peptidase activity	IEA	molecular function
GO:0007613	memory	IEA	biological process
GO:0006508	proteolysis	IEA	biological process
GO:0005764	lysosome	IEA	cellular component
GO:0005764	lysosome	IEA	cellular component
GO:0004197	cysteine-type endopeptidase activity	ISS	molecular function
GO:0070062	extracellular exosome	HDA	cellular component
GO:0006508	proteolysis	ISS	biological process

KEGG pathways

Pathway id	Pathway name
hsa04142	Lysosome
hsa04612	Antigen processing and presentation

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq