|
Gene id |
56339 |
| Gene Summary Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
METTL3 Gene UCSC Ensembl |
|
Aliases |
IME4, M6A, MT-A70, Spo8, hMETTL3 |
|
Gene name |
methyltransferase like 3 |
|
Alternate names |
N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase 70 kDa subunit, adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase, mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase, mRNA m(6)A methyltransferase, methy, |
|
Gene location |
14q11.2 (21511339: 21498137) Exons: 10 NC_000006.12
|
|
Gene summary(Entrez) |
This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. [provided by RefSe
|
|
OMIM |
612472 |
|
| Associated diseases |
References |
| Asthenozoospermia | MIK: 27072590 |
| Asthenozoospermia | MIK: 27072590 |
| Male infertility | MIK: 27072590 |
| Cryptorchidism | MIK: 28606200 |
| Hypospermatogenesis | MIK: 28361989 |
| Teratozoospermia | MIK: 17327269 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 27072590 |
Asthenozoo
spermia, M
ale infert
ility
|
|
|
52 (20 asthenoz
oospermia patie
nts, 32 healthy
controls)
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 28606200 |
Cryptorchi
dism
|
|
|
Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
|
Male infertility |
MeDIP-Seq
|
Show abstract |
| 28361989 |
Hyposperma
togenesis
|
|
|
6 (3 controls,
3 Klienfelter s
yndrome
|
Male infertility |
Microarray
|
Show abstract |
|