• Gene id: 56154

Gene Summary

• Gene Symbol: TEX15   Gene   UCSC   Ensembl
• Aliases: CT42
• Gene name: testis expressed 15, meiosis and synapsis associated
• Alternate names: testis-expressed protein 15, cancer/testis antigen 42, testis-expressed sequence 15 protein,
• Gene location: 8p12 (30913011: 30831543)     Exons: 18     NC_000008.11
• Gene summary(Entrez): This gene encodes a protein that is required for DNA double-strand break repair, chromosome synapsis, and meiotic recombination in spermatocytes. Male mice with a knockout of the orthologous gene are viable but sterile. Loss-of-function mutations in the o
• OMIM: 605795

SNPs

rs864309485

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000008.11   g.30846888A>C
NC_000008.10   g.30704404A>C
NG_053141.1   g.71125T>G
NM_001350162.2   c.3279T>G
NM_001350162.1   c.3279T>G
XM_006716369.4   c.3279T>G
XM_011544593.3   c.2970T>G
XM_011544590.3   c.3279T>G
XM_011544589.3   c.3279T>G
XM_011544591.3   c.3279T>

rs323347

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000008.11   g.30848708A>G
NC_000008.10   g.30706224A>G
NG_053141.1   g.69305T>C
NM_001350162.2   c.1459T>C
NM_001350162.1   c.1459T>C
NP_001337091.1   p.Cys487Arg|SEQ=[A/G]|GENE=TEX15

rs323346

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000008.11   g.30845915T>C
NC_000008.10   g.30703431T>C
NG_053141.1   g.72098A>G
NM_001350162.2   c.4252A>G
NM_001350162.1   c.4252A>G
NP_001337091.1   p.Ile1418Val|SEQ=[T/C]|GENE=TEX15

rs323344

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000008.11   g.30845009A>C
NC_000008.10   g.30702525A>C
NG_053141.1   g.73004T>G
NM_001350162.2   c.5158T>G
NM_001350162.1   c.5158T>G
NP_001337091.1   p.Leu1720Val|SEQ=[A/C]|GENE=TEX15

rs323345

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000008.11   g.30845086T>C
NC_000008.10   g.30702602T>C
NG_053141.1   g.72927A>G
NM_001350162.2   c.5081A>G
NM_001350162.1   c.5081A>G
NP_001337091.1   p.Asn1694Ser|SEQ=[T/C]|GENE=TEX15

Protein Summary

• Protein general information: Q9BXT5  
  • Name: Testis expressed protein 15 (Cancer/testis antigen 42) (CT42)
  • Length: 2789  
  • Mass: 315,336
• Sequence:

  MPSDAKDSVNGDLLLNWTSLKNILSGLNASFPLHNNTGSSTVTTSKSIKDPRLMRREESMGEQSSTAGLNEVLQF
  EKSSDNVNSEIKSTPSNSASSSEVVPGDCAVLTNGLDTPCFKTSVNDSQSWAHNMGSEDYDCIPPNKVTMAGQCK
  DQGNFSFPISVSNVVSEVENQNHSEEKAQRAQQESGNAYTKEYSSHIFQDSQSSDLKTIYQTGCQTSTVFPLKKK
  VSIDEYLQNTGKMKNFADLEDSSKHEEKQTSWKEIDNDFTNETKISPIDNYIVLHQEYKESESHNSFGKSCDKIL
  ITQELEITKSSTSTIKDKDELDHLALEWQITPSFESLSQKHPQHSVEYEGNIHTSLAIAQKLMELKLGKINQNYA
  SIITEAFPKPKDIPQAKEMFIDTVISSYNIETAHDSSNCSITREHICVHRKNENEPVSLENIQRDYKETAYVEDR
  GQDHNLFCNSQLSNDIWLNVNFKKQTDRENQNEAKENSASCVENNIENIYGDKKQDSHTNENFSNIDEKEDKNYH
  NIEILSSEEFSTKFNLICREDNAVSAATALLESEEDTISAVKQKDTENTGRSVEHLASTTFPKTASSSVCVASNA
  AIQIASATMPALSLNNDDHQIYQFKETCSSESPDFGLLVKHRVSDCEIDTDKNKSQESFHQSINENLVLQSIELE
  SEIEIELEDCDDAFIFQQDTHSHENMLCEEFVTSYKALKSRISWEGLLALDNGEMEVLESTTGRENSDQHYSKES
  NYFYSSTQNNETELTSPILLPDLQIKITNIFRPGFSPTADSLALKDSFCTHVTEATKPEINKEDGEILGFDIYSQ
  PFGENADYPCEDKVDNIRQESGPVSNSEISLSFDLSRNTDVNHTSENQNSESLFTEPSNVTTIDDGSRCFFTKSK
  TDYNDTKNKKEVESRISKRKLHISSRDQNIPHKDLRRHKIYGRKRRLTSQDSSECFSSLSQGRIKTFSQSEKHIK
  SVLNILSDEASLCKSKCLSRKLDKAVVHLKKAHRRVHTSLQLITKVGEERKGPLPKSYAIICNNFWESCDLQGYS
  SVSQRKYYSTKHFSSKRKYDKRRKKRAPKADISKSLTHVSKHKSYKTSGEKKCLSRKSMASSVSKSHPTTSHMGE
  FCNQEHPESQLPVSSTSQSTSQSVYYNSSVSNPSLSEEHQPFSGKTAYLFSPDHSDEKLIEKENQIDTAFLSSTS
  KYEKLEKHSANHNVKDATKENSCDANEVINESNSVSLSCIKENINSSTGNDCDATCIGHTKAKTDVLISVLDSNV
  KHFLNDLYQQGNLILSDCKRNLEVKWTDPIERPKQNIITGNFLMGPLNLTLIASKKYSIPQLSAAAVTDSEGESS
  KSYLDKQRILTVDSFAASSTVPHCEQSCREKELLKTEQCSSGNCLHTDGNETNVTENYELDVASGTEEDKSYGEN
  IVELSSSDSSLLLKDNVKGSSSETCIVKKDTEDRITWKVKQAEKAKDSVYKRSMTEGSTVNTEYKNQKNQISEES
  CLNEKIITTNLIDSHLSTKNTTTESVPLKNTVSNPLNKREKKGEIKVSKDSQSDLTLHSEIAYISKPGILGVNHT
  PILPAHSETCKVPTLLKKPASYVSDFKEKHCSANHTALIANLSQILQRADEASSLQILQEETKVCLNILPLFVEA
  FERKQECSVEQILISRELLVDQNLWNNCKHTLKPCAVDTLVELQMMMETIQFIENKKRHLEGEPTLRSLLWYDET
  LYAELLGKPRGFQQQSNFYPGFQGRLKYNAFCELQTYHDQLVELLEETKREKNSYYVFLKYKRQVNECEAIMEHC
  SDCFDFSLSVPFTCGVNFGDSLEDLEILRKSTLKLINVCGDSPKVHSYPGKQDHLWIIIEMISSKVNFIKNNEAV
  RVKISLYGLEHIFFDAAKNLVWKERTQSFSKKYSQKKDEERLLRVNKCAFSKLQKIYDTLSKDLNNEPISPIGLE
  EDTIIASRKSDHPINEATISIENSKFNSNLLAHPDICCISEILDQAEFADLKKLQDLTLRCTDHLEILKKYFQML
  QDNNMDNIFITEENVLDVVINHSHEAIILKPEAIEMYIEIVMVSETIHFLKNSIAKKLDKQRFRGMLWFDLSLLP
  ELVQCQEKMASFSFLKDNSTDVCLWKVIETAVSELKKDLDIICKYNEAVNCSYAIHLLSRELQELSEIKKLLKKS
  KYFISTYIDFVPYIASINYGSTVTELEYNYNQFSTLLKNVMSAPRKDLGKMAHIRKVMKTIEHMKMICTKNAELT
  ISFFLCQMLYNRRKILQLKRKEKMNIHIVKPGENNNKFSISTMLPPVSECINKNISNSSKKRPSTVDKCEDSQEQ
  QQDTTVSSCKKLKVDMKDVTKINREKATFKHPRTTGSHPKSENKIVPSSCDSLKRNHLTPKKVEMQRSLPGSLLP
  LENPKDTCASKSESKIDLTVSSDHFSGQQENLNSMKKRNVNFSAAETKSDKKDCAAFAICDQKSVHGTFSPDHGT
  LLQKFLKNSPDPTQKSCLSDINPETDVSLVPDASVLSKPIFCFVKDVHPDLEMNDTVFELQDNDIVNSSIKNSSC
  MTSPEPICIQNKIPTLQINKLQPTETESEDKYMKDTLNPNTVHTFGASGHITLNVNQGAEYSLSEQQNDKNSKVL
  MQNAATYWNELPQSACNPTYNSSEHLFGTSYPYSAWCVYQYSNSNGNAITQTYQGITSYEVQPSPSGLLTTVAST
  AQGTHSNLLYSQYFTYFAGEPQANGFVPVNGYFQSQIPASNFRQPIFSQYASHQPLPQATYPYLPNRFVPPEVPW
  VYAPWHQESFHPGH

• Structural information:
  • Interpro: IPR026616  IPR032765  
  • STRING: ENSP00000256246
• Other Databases: GeneCards:  TEX15  Malacards:  TEX15

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0006281	DNA repair	IEA	biological process
GO:0007130	synaptonemal complex assembly	IEA	biological process
GO:0007140	male meiosis	IEA	biological process
GO:0007283	spermatogenesis	IEA	biological process
GO:0009566	fertilization	IEA	biological process
GO:0010569	regulation of double-strand break repair via homologous recombination	IEA	biological process
GO:0030154	cell differentiation	IEA	biological process
GO:0030539	male genitalia development	IEA	biological process
GO:0032880	regulation of protein localization	IEA	biological process
GO:0034502	protein localization to chromosome	IEA	biological process
GO:0048873	homeostasis of number of cells within a tissue	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0006281	DNA repair	IEA	biological process
GO:0006974	cellular response to DNA damage stimulus	IEA	biological process
GO:0007129	synapsis	IEA	biological process
GO:0007129	synapsis	IEA	biological process
GO:0007130	synaptonemal complex assembly	IEA	biological process
GO:0007140	male meiosis	IEA	biological process
GO:0007140	male meiosis	IEA	biological process
GO:0007283	spermatogenesis	IEA	biological process
GO:0007283	spermatogenesis	IEA	biological process
GO:0009566	fertilization	IEA	biological process
GO:0010569	regulation of double-strand break repair via homologous recombination	IEA	biological process
GO:0010569	regulation of double-strand break repair via homologous recombination	IEA	biological process
GO:0030154	cell differentiation	IEA	biological process
GO:0030539	male genitalia development	IEA	biological process
GO:0032880	regulation of protein localization	IEA	biological process
GO:0034502	protein localization to chromosome	IEA	biological process
GO:0048873	homeostasis of number of cells within a tissue	IEA	biological process
GO:0051321	meiotic cell cycle	IEA	biological process

Diseases

Associated diseases	References
Spermatogenesis defects	MIK: 26199321
Male factor infertility	MIK: 26086992
Oligozoospermia	MIK: 26086992
Azoospermia	MIK: 26086992
Male infertility	MIK: 26086992
Azoospermia	MIK: 26086992
Oligozoospermia	MIK: 26086992
Nonobstructive azoospermia (NOA)	MIK: 28355598
Sertoli cell only syndrome	MIK: 31479588
Spermatogenic defects	MIK: 22581801
Teratozoospermia	MIK: 17327269
TEX15-deficient spermatocytes exhibit a failure in chromosomal synapsis	MIK: 18283110
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
26086992	Male infertility, Azoospermia, oligozoospermia	rs6525433, rs175080, rs6525433-rs4844247, and rs1800734-rs175080	China	614 (316 patients (244 men with azoospermia, 72 men with oligozoospermia), 298 controls)	Male infertility	TEX11 TEX15  MLH1 and MLH3
26199321	Spermatogenic failure	TEX15 locus (c.2130T>G, p.Y710*)	Turkish	8 (3 infertile, 5 controls)	Male infertility
22581801	Spermatogenic failure	Tex15 (rs323346, rs323347)	Chinese Han	686 (309 infertile men with nonobstructive azoospermia (NOA, n = 199) or severe oligozoospermia (SO, n = 110) and 377 fertile controls)	Male infertility	TEX15
18283110	TEX15-deficient spermatocytes exhibit a failure in chromosomal synapsis				Male infertility
29713536	Sperm number defects	c.2130?T?>?G (p.Y710*)			Male infertility	NGS
31479588	Sertoli cell only syndrome	c.8074G>A p.(Gly2692Arg), c.5969G>A p.(Ser1990Asn)	Brazil, South America n	16 non-obstructive azoospermia	Male infertility	NGS
20378615	Oligozoospermia or azoospermia	rs323344, rs323345	Europea n	442 (158 normospermic controls, 63 moderately oligozoospermic samples, 141 severe oligozoospermic samples and 80 non-obstructed azoospermic samples)	Male infertility	GWAS
28355598	Nonobstructive azoospermia (NOA)	c.2419A>T, p.Lys807*, and c.3040delT, p.Ser1014Leufs*5		5 (2 infertile siblings affected by NOA, 3 fertile males)	Male infertility	NGS
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray