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Gene id 56132
Gene Summary    Protein Summary    Gene ontology    Diseases    PubMed    

Gene Summary

Gene Symbol PCDHB3   Gene   UCSC   Ensembl
Aliases PCDH-BETA3
Gene name protocadherin beta 3
Alternate names protocadherin beta-3,
Gene location 5q31.3 (141100241: 141103826)     Exons: 1     NC_000005.10
Gene summary(Entrez) This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters.
OMIM 606329

Protein Summary

Protein general information Q9Y5E6  

Name: Protocadherin beta 3 (PCDH beta 3)

Length: 796  Mass: 86714

Sequence MEAGGERFLRQRQVLLLFVFLGGSLAGSESRRYSVAEEKEKGFLIANLAKDLGLRVEELAARGAQVVSKGNKQHF
QLSHQTGDLLLNEKLDREELCGPTEPCILHFQILLQNPLQFVTNELRIIDVNDHSPVFFENEMHLKILESTLPGT
VIPLGNAEDLDVGRNSLQNYTITPNSHFHVLTRSRRDGRKYPELVLDKALDPEEQPELSLTLTALDGGSPPRSGT
AQINIQVLDINDNAPEFAQPLYEVAVLENTPVNSVIVTVSASDLDTGSFGTISYAFFHASEEIRKTFQLNPITGD
MQLVKYLNFEAINSYEVDIEAKDGGGLSGKSTVIVQVVDVNDNPPELTLSSVNSPIPENSGETVLAVFSVSDLDS
GDNGRVMCSIENNLPFFLKPSVENFYTLVSEGALDRETRSEYNITITITDLGTPRLKTKYNITVLVSDVNDNAPA
FTQISYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLPLSSLVSINADNGHLFALRSLDYEALQ
AFEFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNA
WLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPE
AAPAQAQADLLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASVGRCSVPEGPFPGQMVDVSGTGTLSQSYQ
YEVCLTGGSGTNEFKFLKPIIPNFVAQGAERVSEANPSFRKSFEFS
Structural information
Protein Domains
(35..13-)
(/note="Cadherin-1)
(/evidence="ECO:0000255|PROSITE-ProRule:PRU00043-)
(138..24-)
(/note="Cadherin-2)
(/evidence="ECO:0000255|PROSITE-ProRule:PRU00043-)
(247..34-)
(/note="Cadherin-3)
(/evidence="ECO:0000255|PROSITE-ProRule:-)
Interpro:  IPR002126  IPR015919  IPR032455  IPR020894  IPR013164  
IPR030735  
Prosite:   PS00232 PS50268
STRING:   ENSP00000231130
Other Databases GeneCards:  PCDHB3  Malacards:  PCDHB3

Gene ontology

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GO accessionTerm nameEvidence codeGo category
GO:0005887 integral component of pla
sma membrane
IBA cellular component
GO:0007155 cell adhesion
IBA biological process
GO:0005509 calcium ion binding
IEA molecular function
GO:0005886 plasma membrane
IEA cellular component
GO:0007155 cell adhesion
IEA biological process
GO:0007156 homophilic cell adhesion
via plasma membrane adhes
ion molecules
IEA biological process
GO:0016020 membrane
IEA cellular component
GO:0007155 cell adhesion
IEA biological process
GO:0016020 membrane
IEA cellular component
GO:0005886 plasma membrane
IEA cellular component
GO:0016021 integral component of mem
brane
IEA cellular component
GO:0005887 integral component of pla
sma membrane
TAS cellular component
GO:0007155 cell adhesion
TAS biological process
GO:0007399 nervous system developmen
t
TAS biological process
GO:0005515 protein binding
IPI molecular function
GO:0005886 plasma membrane
IEA cellular component
GO:0045202 synapse
IEA cellular component
GO:0016339 calcium-dependent cell-ce
ll adhesion via plasma me
mbrane cell adhesion mole
cules
NAS biological process
GO:0016021 integral component of mem
brane
NAS cellular component
GO:0007268 chemical synaptic transmi
ssion
TAS biological process
GO:0007416 synapse assembly
TAS biological process
Associated diseases References
Cryptorchidism MIK: 28606200
Teratozoospermia MIK: 17327269

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
17327269 Teratozoos
permia

13 (5 controls,
8 cases)
Male infertility GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
Show abstract
28606200 Cryptorchi
dism

Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
Male infertility MeDIP-Seq
Show abstract