• Gene id: 5605

Gene Summary

• Gene Symbol: MAP2K2   Gene   UCSC   Ensembl
• Aliases: CFC4, MAPKK2, MEK2, MKK2, PRKMK2
• Gene name: mitogen-activated protein kinase kinase 2
• Alternate names: dual specificity mitogen-activated protein kinase kinase 2, ERK activator kinase 2, MAP kinase kinase 2, MAPK/ERK kinase 2, mitogen-activated protein kinase kinase 2, p45,
• Gene location: 19p13.3 (4124183: 4090320)     Exons: 2     NC_000019.10
• Gene summary(Entrez): The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2
• OMIM: 601263

Protein Summary

• Protein general information: P36507  
  • Name: Dual specificity mitogen activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
  • Length: 400  
  • Mass: 44424
• Sequence:

  MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERI
  SELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHM
  DGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN
  SFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRP
  PGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVE
  EVDFAGWLCKTLRLNQPGTPTRTAV

• Structural information:
  • Protein Domains: (72..36-)
    (/note="Protein-kinase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"-)
  • Interpro: IPR011009  IPR000719  IPR017441  IPR008271  
  • Prosite: PS00107 PS50011 PS00108
  • PDB: 1S9I 4H3Q
  • PDBsum: 1S9I 4H3Q
  • DIP: 29119
  • STRING: ENSP00000262948
• Other Databases: GeneCards:  MAP2K2  Malacards:  MAP2K2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0031098	stress-activated protein kinase signaling cascade	IBA	biological process
GO:0023014	signal transduction by protein phosphorylation	IBA	biological process
GO:0000187	activation of MAPK activity	IBA	biological process
GO:0032147	activation of protein kinase activity	IBA	biological process
GO:0007346	regulation of mitotic cell cycle	IBA	biological process
GO:0005737	cytoplasm	IBA	cellular component
GO:0004708	MAP kinase kinase activity	IBA	molecular function
GO:0004674	protein serine/threonine kinase activity	IBA	molecular function
GO:2000641	regulation of early endosome to late endosome transport	TAS	biological process
GO:0032872	regulation of stress-activated MAPK cascade	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005794	Golgi apparatus	TAS	cellular component
GO:0004712	protein serine/threonine/tyrosine kinase activity	TAS	molecular function
GO:0000187	activation of MAPK activity	TAS	biological process
GO:0090170	regulation of Golgi inheritance	TAS	biological process
GO:0005925	focal adhesion	TAS	cellular component
GO:0005770	late endosome	TAS	cellular component
GO:0005769	early endosome	TAS	cellular component
GO:0005739	mitochondrion	TAS	cellular component
GO:0005634	nucleus	TAS	cellular component
GO:0004672	protein kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0006468	protein phosphorylation	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016301	kinase activity	IEA	molecular function
GO:0004713	protein tyrosine kinase activity	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0016310	phosphorylation	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0005524	ATP binding	IEA	molecular function
GO:0004708	MAP kinase kinase activity	IEA	molecular function
GO:0000165	MAPK cascade	TAS	biological process
GO:0004674	protein serine/threonine kinase activity	TAS	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0070371	ERK1 and ERK2 cascade	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0070371	ERK1 and ERK2 cascade	IMP	biological process
GO:0045893	positive regulation of transcription, DNA-templated	IMP	biological process
GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA	IMP	biological process
GO:0016020	membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0018108	peptidyl-tyrosine phosphorylation	IEA	biological process
GO:0048471	perinuclear region of cytoplasm	IDA	cellular component
GO:0043539	protein serine/threonine kinase activator activity	IDA	molecular function
GO:0036289	peptidyl-serine autophosphorylation	IDA	biological process
GO:0005911	cell-cell junction	IDA	cellular component
GO:0030165	PDZ domain binding	IDA	molecular function
GO:0005874	microtubule	IDA	cellular component
GO:0004708	MAP kinase kinase activity	IDA	molecular function
GO:0071902	positive regulation of protein serine/threonine kinase activity	IDA	biological process
GO:0009898	cytoplasmic side of plasma membrane	IDA	cellular component
GO:0005794	Golgi apparatus	IDA	cellular component
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0010629	negative regulation of gene expression	IGI	biological process
GO:0005576	extracellular region	NAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005778	peroxisomal membrane	HDA	cellular component
GO:0005078	MAP-kinase scaffold activity	IMP	molecular function
GO:0097110	scaffold protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0097110	scaffold protein binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa05200	Pathways in cancer
hsa05010	Alzheimer disease
hsa04151	PI3K-Akt signaling pathway
hsa05165	Human papillomavirus infection
hsa04010	MAPK signaling pathway
hsa05206	MicroRNAs in cancer
hsa04014	Ras signaling pathway
hsa04810	Regulation of actin cytoskeleton
hsa05132	Salmonella infection
hsa04015	Rap1 signaling pathway
hsa04024	cAMP signaling pathway
hsa05166	Human T-cell leukemia virus 1 infection
hsa05163	Human cytomegalovirus infection
hsa05170	Human immunodeficiency virus 1 infection
hsa05205	Proteoglycans in cancer
hsa04022	cGMP-PKG signaling pathway
hsa05167	Kaposi sarcoma-associated herpesvirus infection
hsa04150	mTOR signaling pathway
hsa05225	Hepatocellular carcinoma
hsa04934	Cushing syndrome
hsa04072	Phospholipase D signaling pathway
hsa04140	Autophagy - animal
hsa04921	Oxytocin signaling pathway
hsa05164	Influenza A
hsa04371	Apelin signaling pathway
hsa04910	Insulin signaling pathway
hsa05226	Gastric cancer
hsa04218	Cellular senescence
hsa05161	Hepatitis B
hsa04550	Signaling pathways regulating pluripotency of stem cells
hsa05224	Breast cancer
hsa04270	Vascular smooth muscle contraction
hsa05160	Hepatitis C
hsa05135	Yersinia infection
hsa04210	Apoptosis
hsa04926	Relaxin signaling pathway
hsa04722	Neurotrophin signaling pathway
hsa04071	Sphingolipid signaling pathway
hsa04068	FoxO signaling pathway
hsa04935	Growth hormone synthesis, secretion and action
hsa04919	Thyroid hormone signaling pathway
hsa04915	Estrogen signaling pathway
hsa04650	Natural killer cell mediated cytotoxicity
hsa04916	Melanogenesis
hsa05231	Choline metabolism in cancer
hsa04660	T cell receptor signaling pathway
hsa04620	Toll-like receptor signaling pathway
hsa04066	HIF-1 signaling pathway
hsa04662	B cell receptor signaling pathway
hsa04912	GnRH signaling pathway
hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa04540	Gap junction
hsa04012	ErbB signaling pathway
hsa01522	Endocrine resistance
hsa05210	Colorectal cancer
hsa05220	Chronic myeloid leukemia
hsa05215	Prostate cancer
hsa04720	Long-term potentiation
hsa05214	Glioma
hsa04664	Fc epsilon RI signaling pathway
hsa01521	EGFR tyrosine kinase inhibitor resistance
hsa04917	Prolactin signaling pathway
hsa05221	Acute myeloid leukemia
hsa05211	Renal cell carcinoma
hsa05218	Melanoma
hsa05223	Non-small cell lung cancer
hsa04929	GnRH secretion
hsa04730	Long-term depression
hsa04370	VEGF signaling pathway
hsa05213	Endometrial cancer
hsa05230	Central carbon metabolism in cancer
hsa05216	Thyroid cancer
hsa05020	Prion diseases
hsa05219	Bladder cancer
P06959	CCKR signaling map
P06959	CCKR signaling map
P06959	CCKR signaling map
P06959	CCKR signaling map
P06959	CCKR signaling map
P06959	CCKR signaling map
P06959	CCKR signaling map

Diseases

Associated diseases	References
Noonan syndrome and related disorders	KEGG:H00523
Cardiofaciocutaneous syndrome	KEGG:H01745
Erdheim-Chester disease	KEGG:H02425
Noonan syndrome and related disorders	KEGG:H00523
Cardiofaciocutaneous syndrome	KEGG:H01745
Erdheim-Chester disease	KEGG:H02425
Breast cancer	PMID:10216485
Glioblastoma multiforme	PMID:26189368
small intestine adenocarcinoma	PMID:19014680
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq