• Gene id: 5603

Gene Summary

• Gene Symbol: MAPK13   Gene   UCSC   Ensembl
• Aliases: MAPK 13, MAPK-13, PRKM13, SAPK4, p38delta
• Gene name: mitogen-activated protein kinase 13
• Alternate names: mitogen-activated protein kinase 13, MAP kinase 13, MAP kinase p38 delta, mitogen-activated protein kinase p38 delta, stress-activated protein kinase 4,
• Gene location: 6p21.31 (36130512: 36144520)     Exons: 13     NC_000006.12
• Gene summary(Entrez): This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, tra
• OMIM: 606319

Protein Summary

• Protein general information: O15264  
  • Name: Mitogen activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress activated protein kinase 4)
  • Length: 365  
  • Mass: 42090
  • Tissue specificity: Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells. {ECO
• Sequence:

  MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLL
  LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRD
  LKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKG
  KDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA
  QALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDSRRRSGMKL

• Structural information:
  • Protein Domains: (25..30-)
    (/note="Protein-kinase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"-)
  • Interpro: IPR011009  IPR003527  IPR008352  IPR038785  IPR000719   IPR017441  
  • Prosite: PS01351 PS00107 PS50011
  • CDD: cd07879
  • PDB: 3COI 4EYJ 4EYM 4MYG 4YNO 5EKN 5EKO
  • PDBsum: 3COI 4EYJ 4EYM 4MYG 4YNO 5EKN 5EKO
  • STRING: ENSP00000211287
• Other Databases: GeneCards:  MAPK13  Malacards:  MAPK13

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004707	MAP kinase activity	IBA	molecular function
GO:0035556	intracellular signal transduction	IBA	biological process
GO:0010468	regulation of gene expression	IBA	biological process
GO:0005737	cytoplasm	IBA	cellular component
GO:0005634	nucleus	IBA	cellular component
GO:0004707	MAP kinase activity	IDA	molecular function
GO:0006970	response to osmotic stress	IDA	biological process
GO:0004707	MAP kinase activity	IEA	molecular function
GO:0000165	MAPK cascade	IEA	biological process
GO:0004672	protein kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0006468	protein phosphorylation	IEA	biological process
GO:0016301	kinase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0007049	cell cycle	IEA	biological process
GO:0004707	MAP kinase activity	IEA	molecular function
GO:0004674	protein serine/threonine kinase activity	IDA	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0004674	protein serine/threonine kinase activity	IDA	molecular function
GO:0018105	peptidyl-serine phosphorylation	IDA	biological process
GO:0050729	positive regulation of inflammatory response	IC	biological process
GO:0032755	positive regulation of interleukin-6 production	IMP	biological process
GO:0051403	stress-activated MAPK cascade	IDA	biological process
GO:0004707	MAP kinase activity	IDA	molecular function
GO:0072740	cellular response to anisomycin	IDA	biological process
GO:0072709	cellular response to sorbitol	IDA	biological process
GO:1903936	cellular response to sodium arsenite	IDA	biological process
GO:0071347	cellular response to interleukin-1	IDA	biological process
GO:0070301	cellular response to hydrogen peroxide	IDA	biological process
GO:0034644	cellular response to UV	IDA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04010	MAPK signaling pathway
hsa04714	Thermogenesis
hsa05131	Shigellosis
hsa05132	Salmonella infection
hsa04015	Rap1 signaling pathway
hsa05163	Human cytomegalovirus infection
hsa05130	Pathogenic Escherichia coli infection
hsa05170	Human immunodeficiency virus 1 infection
hsa05205	Proteoglycans in cancer
hsa05169	Epstein-Barr virus infection
hsa05167	Kaposi sarcoma-associated herpesvirus infection
hsa04621	NOD-like receptor signaling pathway
hsa04723	Retrograde endocannabinoid signaling
hsa04261	Adrenergic signaling in cardiomyocytes
hsa05152	Tuberculosis
hsa04218	Cellular senescence
hsa05161	Hepatitis B
hsa04728	Dopaminergic synapse
hsa04550	Signaling pathways regulating pluripotency of stem cells
hsa04380	Osteoclast differentiation
hsa05418	Fluid shear stress and atherosclerosis
hsa04114	Oocyte meiosis
hsa05135	Yersinia infection
hsa04611	Platelet activation
hsa04926	Relaxin signaling pathway
hsa04722	Neurotrophin signaling pathway
hsa04071	Sphingolipid signaling pathway
hsa04068	FoxO signaling pathway
hsa04670	Leukocyte transendothelial migration
hsa04935	Growth hormone synthesis, secretion and action
hsa04668	TNF signaling pathway
hsa04625	C-type lectin receptor signaling pathway
hsa04660	T cell receptor signaling pathway
hsa04750	Inflammatory mediator regulation of TRP channels
hsa04659	Th17 cell differentiation
hsa04620	Toll-like receptor signaling pathway
hsa05145	Toxoplasmosis
hsa04914	Progesterone-mediated oocyte maturation
hsa04912	GnRH signaling pathway
hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05142	Chagas disease
hsa04658	Th1 and Th2 cell differentiation
hsa04933	AGE-RAGE signaling pathway in diabetic complications
hsa01522	Endocrine resistance
hsa04657	IL-17 signaling pathway
hsa05120	Epithelial cell signaling in Helicobacter pylori infection
hsa04622	RIG-I-like receptor signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa05133	Pertussis
hsa04917	Prolactin signaling pathway
hsa05140	Leishmaniasis
hsa05014	Amyotrophic lateral sclerosis
hsa04370	VEGF signaling pathway

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray