• Gene id: 55937

Gene Summary

• Gene Symbol: APOM   Gene   UCSC   Ensembl
• Aliases: G3a, HSPC336, NG20, apo-M
• Gene name: apolipoprotein M
• Alternate names: apolipoprotein M, NG20-like protein, alternative name: G3a, NG20, protein G3a,
• Gene location: 6p21.33 (31652403: 31658209)     Exons: 7     NC_000006.12
• Gene summary(Entrez): The protein encoded by this gene is an apolipoprotein and member of the lipocalin protein family. It is found associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. The encoded pr
• OMIM: 610434

Protein Summary

• Protein general information: O95445  
  • Name: Apolipoprotein M (Apo M) (ApoM) (Protein G3a)
  • Length: 188  
  • Mass: 21253
  • Tissue specificity: Plasma protein. Expressed in liver and kidney.
• Sequence:

  MFHQIWAALLYFYGIILNSIYQCPEHSQLTTLGVDGKEFPEVHLGQWYFIAGAAPTKEELATFDPVDNIVFNMAA
  GSAPMQLHLRATIRMKDGLCVPRKWIYHLTEGSTDLRTEGRPDMKTELFSSSCPGGIMLNETGQGYQRFLLYNRS
  PHPPEKCVEEFKSLTSCLDSKAFLLTPRNQEACELSNN

• Structural information:
  • Interpro: IPR022734  IPR012674  
  • PDB: 2WEW 2WEX 2YG2
  • PDBsum: 2WEW 2WEX 2YG2
  • STRING: ENSP00000365081
• Other Databases: GeneCards:  APOM  Malacards:  APOM

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0034384	high-density lipoprotein particle clearance	IBA	biological process
GO:0034375	high-density lipoprotein particle remodeling	IBA	biological process
GO:0034362	low-density lipoprotein particle	IBA	cellular component
GO:0033344	cholesterol efflux	IBA	biological process
GO:0005319	lipid transporter activity	IBA	molecular function
GO:0034380	high-density lipoprotein particle assembly	IBA	biological process
GO:0034364	high-density lipoprotein particle	IBA	cellular component
GO:0034361	very-low-density lipoprotein particle	IBA	cellular component
GO:0005543	phospholipid binding	IBA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0034364	high-density lipoprotein particle	IEA	cellular component
GO:0006869	lipid transport	IEA	biological process
GO:0001523	retinoid metabolic process	TAS	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0009749	response to glucose	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0033344	cholesterol efflux	IEA	biological process
GO:0034365	discoidal high-density lipoprotein particle	IEA	cellular component
GO:0034375	high-density lipoprotein particle remodeling	IEA	biological process
GO:0034384	high-density lipoprotein particle clearance	IEA	biological process
GO:0034445	negative regulation of plasma lipoprotein oxidation	IEA	biological process
GO:0042157	lipoprotein metabolic process	IEA	biological process
GO:0043691	reverse cholesterol transport	IEA	biological process
GO:0016209	antioxidant activity	IEA	molecular function
GO:0034364	high-density lipoprotein particle	IEA	cellular component
GO:0034380	high-density lipoprotein particle assembly	IEA	biological process
GO:0005319	lipid transporter activity	IDA	molecular function
GO:0005543	phospholipid binding	IDA	molecular function
GO:0016209	antioxidant activity	IDA	molecular function
GO:0033344	cholesterol efflux	IDA	biological process
GO:0034362	low-density lipoprotein particle	IDA	cellular component
GO:0034365	discoidal high-density lipoprotein particle	IDA	cellular component
GO:0034366	spherical high-density lipoprotein particle	IDA	cellular component
GO:0034445	negative regulation of plasma lipoprotein oxidation	IDA	biological process
GO:0034445	negative regulation of plasma lipoprotein oxidation	IDA	biological process
GO:0042632	cholesterol homeostasis	IC	biological process
GO:0033344	cholesterol efflux	IMP	biological process
GO:0034375	high-density lipoprotein particle remodeling	IMP	biological process
GO:0034384	high-density lipoprotein particle clearance	ISS	biological process
GO:0043691	reverse cholesterol transport	ISS	biological process
GO:0034361	very-low-density lipoprotein particle	IDA	cellular component
GO:0034364	high-density lipoprotein particle	IDA	cellular component
GO:0034380	high-density lipoprotein particle assembly	ISS	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0098869	cellular oxidant detoxification	IEA	biological process
GO:0098869	cellular oxidant detoxification	IEA	biological process

Diseases

Associated diseases	References
Coronary artery disease	PMID:17674965
type 2 diabetes mellitus	PMID:16572495
type 1 diabetes mellitus	PMID:19007767
Spermatogenic defects	MIK: 31037746
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray