• Gene id: 55911

Gene Summary

• Gene Symbol: APOBR   Gene   UCSC   Ensembl
• Aliases: APOB100R, APOB48R
• Gene name: apolipoprotein B receptor
• Alternate names: apolipoprotein B receptor, apoB-48R, apolipoprotein B-100 receptor, apolipoprotein B-48 receptor, apolipoprotein B100 receptor, apolipoprotein B48 receptor,
• Gene location: 16p12.1 (28494642: 28498963)     Exons: 4     NC_000016.10
• Gene summary(Entrez): Apolipoprotein B48 receptor is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG)-rich lipoproteins. This receptor may provide essential lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells.

Protein Summary

• Protein general information: Q0VD83  
  • Name: Apolipoprotein B receptor (Apolipoprotein B 100 receptor) (Apolipoprotein B 48 receptor) (Apolipoprotein B48 receptor) (apoB 48R)
  • Length: 1097  
  • Mass: 115634
  • Tissue specificity: Expressed in peripheral blood leukocytes > bone marrow = spleen > lymph node, and only faintly visible in appendix and thymus. Expressed in the brain, heart, kidney, liver, lung, pancreas, and placenta. Expressed primarily by reticuloe
• Sequence:

  MDFLRLYLPGLHQALRGALDSLGTFVSYLLGDAVPTVEREAQAAEELGVVAVGKTGKIVEEEAQEDLEGLRGSQN
  EGAGRLRGPGDDRRHEVGSSAVEQTWGWGDGSSHGSQAERQDSGAGETAKAARCQEPSAHLEARKKSKAGSGACQ
  DRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVRAREPGMARGAESEWTWHGETEGKAGAVGPKAAGDNREME
  QGVREADAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEE
  ARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGGEEAGTASGGDEAWTT
  SGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVLGTERTEEAAESQTAGREAV
  GGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPE
  ARPEEELTGEESEAAQTSCGLLGVEWGGLTHSVTKGQGPELMGGAQTPTKQPEEREAGEVELMGVLALSKEEQER
  SLEAGPRHAGSVKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESELSEVPE
  AGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEAYARETEDEEAEADRTSRRGWRLQAVAVGLP
  DREDAQTGSVAAGIMGGDVVPHISAAGAGEALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQ
  VEAFESREGGPWGGRVEAEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDS
  EGRCGDYHPEGEAPRLLDAEGLMVTGGRRAEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETAEAMGSA
  RGGAANSWSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSRPSFRRTPAWEQQEEPPAPNPPEEELSAPEQRPLQLE
  EPLEPSPLRHDGTPVPARRRPLGHGFGLAHPGMMQELQARLGRPKPQ

• Structural information:
  • Interpro: IPR026158  
  • STRING: ENSP00000457539
• Other Databases: GeneCards:  APOBR  Malacards:  APOBR

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006641	triglyceride metabolic process	IBA	biological process
GO:0030229	very-low-density lipoprotein particle receptor activity	IBA	molecular function
GO:0030228	lipoprotein particle receptor activity	IEA	molecular function
GO:0006869	lipid transport	IEA	biological process
GO:0042627	chylomicron	IEA	cellular component
GO:0034362	low-density lipoprotein particle	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0006869	lipid transport	IEA	biological process
GO:0008203	cholesterol metabolic process	IEA	biological process
GO:0034361	very-low-density lipoprotein particle	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0008202	steroid metabolic process	IEA	biological process
GO:0006629	lipid metabolic process	IEA	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0034447	very-low-density lipoprotein particle clearance	TAS	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0006897	endocytosis	IEA	biological process
GO:0006897	endocytosis	IEA	biological process
GO:0016020	membrane	HDA	cellular component

Diseases

Associated diseases	References
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray