• Gene id: 55872

Gene Summary

• Gene Symbol: PBK   Gene   UCSC   Ensembl
• Aliases: CT84, HEL164, Nori-3, SPK, TOPK
• Gene name: PDZ binding kinase
• Alternate names: lymphokine-activated killer T-cell-originated protein kinase, MAPKK-like protein kinase, T-LAK cell-originated protein kinase, cancer/testis antigen 84, epididymis luminal protein 164, serine/threonine protein kinase, spermatogenesis-related protein kinase,
• Gene location: 8p21.1 (27837816: 27809623)     Exons: 8     NC_000074.6
• Gene summary(Entrez): This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be invo
• OMIM: 611210

Diseases

Associated diseases	References
Chronic renal failure	GAD: 21085059
Spermatogenesis defects	MIK: 11378444
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Involved in spermatogenesis, Male infertility	MIK: 11378444
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
11378444	Involved in spermatogenesis, Male infertility				Male infertility
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R