• Gene id: 55825

Gene Summary

• Gene Symbol: PECR   Gene   UCSC   Ensembl
• Aliases: DCRRP, HPDHASE, HSA250303, PVIARL, SDR29C1, TERP
• Gene name: peroxisomal trans-2-enoyl-CoA reductase
• Alternate names: peroxisomal trans-2-enoyl-CoA reductase, 2,4-dienoyl-CoA reductase-related protein, DCR-RP, pVI-ARL, putative short chain alcohol dehydrogenase, short chain dehydrogenase/reductase family 29C member 1,
• Gene location: 2q35 (216081842: 216031655)     Exons: 10     NC_000002.12
• OMIM: 603743

Protein Summary

• Protein general information: Q9BY49  
  • Name: Peroxisomal trans 2 enoyl CoA reductase (TERP) (EC 1.3.1.38) (2,4 dienoyl CoA reductase related protein) (DCR RP) (HPDHase) (Short chain dehydrogenase/reductase family 29C member 1) (pVI ARL)
  • Length: 303  
  • Mass: 32544
• Sequence:

  MASWAKGRSYLAPGLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI
  PIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGTFYMCKAVYSSWMKEH
  GGSIVNIIVPTKAGFPLAVHSGAARAGVYNLTKSLALEWACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSF
  QKIPAKRIGVPEEVSSVVCFLLSPAASFITGQSVDVDGGRSLYTHSYEVPDHDNWPKGAGDLSVVKKMKETFKEK
  AKL

• Structural information:
  • Interpro: IPR036291  IPR002347  
  • PDB: 1YXM
  • PDBsum: 1YXM
  • STRING: ENSP00000265322
• Other Databases: GeneCards:  PECR  Malacards:  PECR

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0055114	oxidation-reduction process	IBA	biological process
GO:0033306	phytol metabolic process	IBA	biological process
GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity	IBA	molecular function
GO:0005777	peroxisome	IBA	cellular component
GO:0006633	fatty acid biosynthetic process	IEA	biological process
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0006629	lipid metabolic process	IEA	biological process
GO:0006631	fatty acid metabolic process	IEA	biological process
GO:0005777	peroxisome	IEA	cellular component
GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity	IEA	molecular function
GO:0001561	fatty acid alpha-oxidation	TAS	biological process
GO:0005778	peroxisomal membrane	TAS	cellular component
GO:0005778	peroxisomal membrane	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006625	protein targeting to peroxisome	TAS	biological process
GO:0005739	mitochondrion	IEA	cellular component
GO:0005777	peroxisome	IEA	cellular component
GO:0005777	peroxisome	IDA	cellular component
GO:0006633	fatty acid biosynthetic process	IEA	biological process
GO:0033306	phytol metabolic process	IDA	biological process
GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity	IDA	molecular function
GO:0005777	peroxisome	IDA	cellular component
GO:0055114	oxidation-reduction process	IDA	biological process
GO:0008670	2,4-dienoyl-CoA reductase (NADPH) activity	IDA	NOT|molecular function
GO:0005102	signaling receptor binding	IPI	molecular function
GO:0005778	peroxisomal membrane	ISS	cellular component
GO:0005778	peroxisomal membrane	ISS	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04146	Peroxisome

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R