• Gene id: 55811

Gene Summary

• Gene Symbol: ADCY10   Gene   UCSC   Ensembl
• Aliases: HCA2, HEL-S-7a, SAC, SACI, Sacy, hsAC
• Gene name: adenylate cyclase 10
• Alternate names: adenylate cyclase type 10, 3',5'-cyclic AMP synthetase, AH-related protein, ATP pyrophosphate-lyase, adenylate cyclase 10, soluble, epididymis secretory sperm binding protein Li 7a, germ cell soluble adenylyl cyclase, testicular soluble adenylyl cyclase (,
• Gene location: 1q24.2 (167916388: 167809079)     Exons: 36     NC_000001.11
• Gene summary(Entrez): The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patie
• OMIM: 605205

SNPs

rs779944215

Strand:    Allele origin:   Allele change:   Mutation type: delins

NC_000001.11   g.167880125_167880126GT[1]
NC_000001.10   g.167849363_167849364GT[1]
NG_016139.1   g.39088_39089AC[1]
NM_018417.6   c.1203_1204AC[1]
NM_018417.5   c.1203_1204AC[1]
NM_018417.4   c.1203_1204AC[1]
NM_001167749.3   c.744_745AC[1]
NM_001167749.2   c.744_7

Protein Summary

• Protein general information: Q96PN6  
  • Name: Adenylate cyclase type 10 (EC 4.6.1.1) (AH related protein) (Adenylate cyclase homolog) (Germ cell soluble adenylyl cyclase) (hsAC) (sAC) (Testicular soluble adenylyl cyclase)
  • Length: 1610  
  • Mass: 187,149
• Sequence:

  MNTPKEEFQDWPIVRIAAHLPDLIVYGHFSPERPFMDYFDGVLMFVDISGFTAMTEKFSSAMYMDRGAEQLVEIL
  NYHISAIVEKVLIFGGDILKFAGDALLALWRVERKQLKNIITVVIKCSLEIHGLFETQEWEEGLDIRVKIGLAAG
  HISMLVFGDETHSHFLVIGQAVDDVRLAQNMAQMNDVILSPNCWQLCDRSMIEIESVPDQRAVKVNFLKPPPNFN
  FDEFFTKCTTFMHYYPSGEHKNLLRLACTLKPDPELEMSLQKYVMESILKQIDNKQLQGYLSELRPVTIVFVNLM
  FEDQDKAEEIGPAIQDAYMHITSVLKIFQGQINKVFMFDKGCSFLCVFGFPGEKVPDELTHALECAMDIFDFCSQ
  VHKIQTVSIGVASGIVFCGIVGHTVRHEYTVIGQKVNLAARMMMYYPGIVTCDSVTYNGSNLPAYFFKELPKKVM
  KGVADSGPLYQYWGRTEKVMFGMACLICNRKEDYPLLGRNKEINYFMYTMKKFLISNSSQVLMYEGLPGYGKSQI
  LMKIEYLAQGKNHRIIAISLNKISFHQTFYTIQMFMANVLGLDTCKHYKERQTNLRNKVMTLLDEKFYCLLNDIF
  HVQFPISREISRMSTLKKQKQLEILFMKILKLIVKEERIIFIIDEAQFVDSTSWRFMEKLIRTLPIFIIMSLCPF
  VNIPCAAARAVIKNRNTTYIVIGAVQPNDISNKICLDLNVSCISKELDSYLGEGSCGIPFYCEELLKNLEHHEVL
  VFQQTESEEKTNRTWNNLFKYSIKLTEKLNMVTLHSDKESEEVCHLTSGVRLKNLSPPTSLKEISLIQLDSMRLS
  HQMLVRCAAIIGLTFTTELLFEILPCWNMKMMIKTLATLVESNIFYCFRNGKELQKALKQNDPSFEVHYRSLSLK
  PSEGMDHGEEEQLRELENEVIECHRIRFCNPMMQKTAYELWLKDQRKAMHLKCARFLEEDAHRCDHCRGRDFIPY
  HHFTVNIRLNALDMDAIKKMAMSHGFKTEEKLILSNSEIPETSAFFPENRSPEEIREKILNFFDHVLTKMKTSDE
  DIIPLESCQCEEILEIVILPLAHHFLALGENDKALYYFLEIASAYLIFCDNYMAYMYLNEGQKLLKTLKKDKSWS
  QTFESATFYSLKGEVCFNMGQIVLAKKMLRKALKLLNRIFPYNLISLFLHIHVEKNRHFHYVNRQAQESPPPGKK
  RLAQLYRQTVCLSLLWRIYSYSYLFHCKYYAHLAVMMQMNTALETQNCFQIIKAYLDYSLYHHLAGYKGVWFKYE
  VMAMEHIFNLPLKGEGIEIVAYVAETLVFNKLIMGHLDLAIELGSRALQMWALLQNPNRHYQSLCRLSRCLLLNS
  RYPQLIQVLGRLWELSVTQEHIFSKAFFYFVCLDILLYSGFVYRTFEECLEFIHQYENNRILKFHSGLLLGLYSS
  VAIWYARLQEWDNFYKFSNRAKNLLPRRTMTLTYYDGISRYMEGQVLHLQKQIKEQSENAQASGEELLKNLENLV
  AQNTTGPVFCPRLYHLMAYVCILMGDGQKCGLFLNTALRLSETQGNILEKCWLNMNKESWYSTSELKEDQWLQTI
  LSLPSWEKIVAGRVNIQDLQKNKFLMRANTVDNHF

• Structural information:
  • Protein Domains: Guanylate (42-179)
    Guanylate (293-418)
  • Interpro: IPR001054  IPR016577  IPR029787  IPR027417  
  • Prosite: PS50125
  • PDB: 4CLF 4CLK 4CLL 4CLP 4CLS 4CLT 4CLU 4CLW 4CLY 4CLZ 4CM0 4CM2 4OYA 4OYB 4OYI 4OYM 4OYO 4OYP 4OYW 4OYX 4OYZ 4OZ2 4OZ3 4UST 4USU 4USV 4USW 5D0R 5IV3 5IV4
  • PDBsum: 4CLF 4CLK 4CLL 4CLP 4CLS 4CLT 4CLU 4CLW 4CLY 4CLZ 4CM0 4CM2 4OYA 4OYB 4OYI 4OYM 4OYO 4OYP 4OYW 4OYX 4OYZ 4OZ2 4OZ3 4UST 4USU 4USV 4USW 5D0R 5IV3 5IV4
  • STRING: ENSP00000356825
• Other Databases: GeneCards:  ADCY10  Malacards:  ADCY10

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000287	magnesium ion binding	IEA	molecular function
GO:0003351	epithelial cilium movement	IMP	biological process
GO:0004016	adenylate cyclase activity	IDA	molecular function
GO:0004016	adenylate cyclase activity	IDA	molecular function
GO:0004016	adenylate cyclase activity	NAS	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0005737	cytoplasm	TAS	cellular component
GO:0005739	mitochondrion	IEA	cellular component
GO:0005829	cytosol	NAS	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0006171	cAMP biosynthetic process	IDA	biological process
GO:0006171	cAMP biosynthetic process	IDA	biological process
GO:0006171	cAMP biosynthetic process	NAS	biological process
GO:0007283	spermatogenesis	IEA	biological process
GO:0030145	manganese ion binding	IEA	molecular function
GO:0030424	axon	IEA	cellular component
GO:0030425	dendrite	IEA	cellular component
GO:0030426	growth cone	IEA	cellular component
GO:0035556	intracellular signal transduction	IEA	biological process
GO:0043025	neuronal cell body	IEA	cellular component
GO:0043065	positive regulation of apoptotic process	IEA	biological process
GO:0045177	apical part of cell	IEA	cellular component
GO:0045178	basal part of cell	IEA	cellular component
GO:0048471	perinuclear region of cytoplasm	IDA	cellular component
GO:0051117	ATPase binding	IEA	molecular function
GO:0071241	cellular response to inorganic substance	IDA	biological process
GO:0071890	bicarbonate binding	IDA	molecular function
GO:0015630	microtubule cytoskeleton	IDA	cellular component
GO:0031514	motile cilium	IDA	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0000287	magnesium ion binding	IEA	molecular function
GO:0003351	epithelial cilium movement	IMP	biological process
GO:0004016	adenylate cyclase activity	IEA	molecular function
GO:0004016	adenylate cyclase activity	IEA	molecular function
GO:0004016	adenylate cyclase activity	IEA	molecular function
GO:0004016	adenylate cyclase activity	IDA	molecular function
GO:0004016	adenylate cyclase activity	IDA	molecular function
GO:0004016	adenylate cyclase activity	NAS	molecular function
GO:0004016	adenylate cyclase activity	TAS	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	TAS	cellular component
GO:0005739	mitochondrion	IEA	cellular component
GO:0005739	mitochondrion	IEA	cellular component
GO:0005829	cytosol	IEA	cellular component
GO:0005829	cytosol	NAS	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005929	cilium	IEA	cellular component
GO:0006171	cAMP biosynthetic process	IEA	biological process
GO:0006171	cAMP biosynthetic process	IEA	biological process
GO:0006171	cAMP biosynthetic process	IEA	biological process
GO:0006171	cAMP biosynthetic process	IDA	biological process
GO:0006171	cAMP biosynthetic process	IDA	biological process
GO:0006171	cAMP biosynthetic process	NAS	biological process
GO:0007283	spermatogenesis	IEA	biological process
GO:0009190	cyclic nucleotide biosynthetic process	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016829	lyase activity	IEA	molecular function
GO:0016849	phosphorus-oxygen lyase activity	IEA	molecular function
GO:0030145	manganese ion binding	IEA	molecular function
GO:0030424	axon	IEA	cellular component
GO:0030425	dendrite	IEA	cellular component
GO:0030426	growth cone	IEA	cellular component
GO:0035556	intracellular signal transduction	IEA	biological process
GO:0042995	cell projection	IEA	cellular component
GO:0043025	neuronal cell body	IEA	cellular component
GO:0043065	positive regulation of apoptotic process	IEA	biological process
GO:0045177	apical part of cell	IEA	cellular component
GO:0045178	basal part of cell	IEA	cellular component
GO:0046872	metal ion binding	IEA	molecular function
GO:0048471	perinuclear region of cytoplasm	IEA	cellular component
GO:0048471	perinuclear region of cytoplasm	IDA	cellular component
GO:0051117	ATPase binding	IEA	molecular function
GO:0071241	cellular response to inorganic substance	IDA	biological process
GO:0071890	bicarbonate binding	IDA	molecular function
GO:0015630	microtubule cytoskeleton	IDA	cellular component
GO:0031514	motile cilium	IDA	cellular component
GO:0003351	epithelial cilium movement	IMP	biological process
GO:0004016	adenylate cyclase activity	IDA	molecular function
GO:0004016	adenylate cyclase activity	IDA	molecular function
GO:0004016	adenylate cyclase activity	NAS	molecular function
GO:0004016	adenylate cyclase activity	TAS	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0005737	cytoplasm	TAS	cellular component
GO:0005829	cytosol	NAS	cellular component
GO:0006171	cAMP biosynthetic process	IDA	biological process
GO:0006171	cAMP biosynthetic process	IDA	biological process
GO:0006171	cAMP biosynthetic process	NAS	biological process
GO:0048471	perinuclear region of cytoplasm	IDA	cellular component
GO:0071241	cellular response to inorganic substance	IDA	biological process
GO:0071890	bicarbonate binding	IDA	molecular function
GO:0015630	microtubule cytoskeleton	IDA	cellular component
GO:0031514	motile cilium	IDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa04024	cAMP signaling pathway
hsa04713	Circadian entrainment
hsa04714	Thermogenesis

Diseases

Associated diseases	References
Hypertension	GAD: 19536175
Osteoporosis	GAD: 19064610
Bone diseases	GAD: 19093065
Male factor infertility	MIK: 21255775
Asthenozoospermia	MIK: 21255775
Asthenozoospermia	MIK: 31119281
Asthenozoospermia	MIK: 21255775
Spermatogenic defects	MIK: 31037746
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21255775	Asthenozoospermia	AKAP4 (c.887G>A -> p.Gly296Asn), CATSPER4 (c.247A>G -> p.Met83Val; c.157T>C -> p.Tyr53His; c.992G>A -> p.Gly331Asn), CATSPER1 (c.148G>A -> p.Val50Met), CATSPER3 (c.193T>C -> p.Phe65Leu), CATSPER2 (c.1289C>G -> p.Thr430Arg), PLA2G6 (c.187A>G -> p.Arg63Gly		30 men with isolated asthenozoospermia	Male infertility	ADCY10 AKAP4 CATSPER1 CATSPER2 CATSPER3 CATSPER4  GAPDHS PLA2G6 and SLC9A10
31119281	Asthenozoospermia	c.1205_1206del, rs779944215, p.His402Argfs*41		20 (10 normozoospermic men, 10 asthenozoospermic patients)	Male infertility	NGS
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R