• Gene id: 55783

Gene Summary

• Gene Symbol: CMTR2   Gene   UCSC   Ensembl
• Aliases: AFT, FTSJD1, HMTr2, MTr2
• Gene name: cap methyltransferase 2
• Alternate names: cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2, FtsJ methyltransferase domain containing 1, adrift homolog, cap2 2'O-ribose methyltransferase 2, ftsJ methyltransferase domain-containing protein 1, protein adrift homolog,
• Gene location: 16q22.2 (71290177: 71281391)     Exons: 4     NC_000016.10
• OMIM: 616190

Protein Summary

• Protein general information: Q8IYT2  
  • Name: Cap specific mRNA (nucleoside 2' O ) methyltransferase 2 (EC 2.1.1.296) (Cap methyltransferase 2) (Cap2 2'O ribose methyltransferase 2) (HMTr2) (MTr2) (FtsJ methyltransferase domain containing protein 1) (Protein adrift homolog)
  • Length: 770  
  • Mass: 88120
• Sequence:

  MSKCRKTPVQQLASPASFSPDILADIFELFAKNFSYGKPLNNEWQLPDPSEIFTCDHTELNAFLDLKNSLNEVKN
  LLSDKKLDEWHEHTAFTNKAGKIISHVRKSVNAELCTQAWCKFHEILCSFPLIPQEAFQNGKLNSLHLCEAPGAF
  IASLNHYLKSHRFPCHWSWVANTLNPYHEANDDLMMIMDDRLIANTLHWWYFGPDNTGDIMTLKFLTGLQNFISS
  MATVHLVTADGSFDCQGNPGEQEALVSSLHYCEVVTALTTLGNGGSFVLKMFTMFEHCSINLMYLLNCCFDQVHV
  FKPATSKAGNSEVYVVCLHYKGREAIHPLLSKMTLNFGTEMKRKALFPHHVIPDSFLKRHEECCVFFHKYQLETI
  SENIRLFECMGKAEQEKLNNLRDCAIQYFMQKFQLKHLSRNNWLVKKSSIGCSTNTKWFGQRNKYFKTYNERKML
  EALSWKDKVAKGYFNSWAEEHGVYHPGQSSILEGTASNLECHLWHILEGKKLPKVKCSPFCNGEILKTLNEAIEK
  SLGGAFNLDSKFRPKQQYSCSCHVFSEELIFSELCSLTECLQDEQVVVPSNQIKCLLVGFSTLRNIKMHIPLEVR
  LLESAELTTFSCSLLHDGDPTYQRLFLDCLLHSLRELHTGDVMILPVLSCFTRFMAGLIFVLHSCFRFITFVCPT
  SSDPLRTCAVLLCVGYQDLPNPVFRYLQSVNELLSTLLNSDSPQQVLQFVPMEVLLKGALLDFLWDLNAAIAKRH
  LHFIIQREREEIINSLQLQN

• Structural information:
  • Protein Domains: (109..32-)
    2'-O-MTase (/note="Adrift-type-SAM-dependent)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00946"-)
  • Interpro: IPR025807  IPR002877  IPR029063  
  • Prosite: PS51614
  • STRING: ENSP00000337512
• Other Databases: GeneCards:  CMTR2  Malacards:  CMTR2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0097310	cap2 mRNA methylation	IBA	biological process
GO:0006370	7-methylguanosine mRNA capping	IBA	biological process
GO:0004483	mRNA (nucleoside-2'-O-)-methyltransferase activity	IBA	molecular function
GO:0097309	cap1 mRNA methylation	IBA	biological process
GO:0005737	cytoplasm	IBA	cellular component
GO:0005634	nucleus	IBA	cellular component
GO:0097310	cap2 mRNA methylation	IDA	biological process
GO:0006370	7-methylguanosine mRNA capping	IDA	biological process
GO:0004483	mRNA (nucleoside-2'-O-)-methyltransferase activity	IDA	molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0032259	methylation	IEA	biological process
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0032259	methylation	IEA	biological process
GO:0006370	7-methylguanosine mRNA capping	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0006397	mRNA processing	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R