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Gene id 5578
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary
Gene Symbol PRKCA   Gene   UCSC   Ensembl
Aliases AAG6, PKC-alpha, PKCA, PKCI+/-, PKCalpha, PRKACA
Gene name protein kinase C alpha
Alternate names protein kinase C alpha type, PKC-A, aging-associated gene 6,
Gene location 17q24.2 (66302612: 66810742)     Exons: 24     NC_000012.12
Gene summary(Entrez) Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved
OMIM 176960

Protein Summary

Gene ontology

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GO accessionTerm nameEvidence codeGo category

KEGG pathways

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Pathway idPathway name
hsa04066HIF-1 signaling pathway
hsa04020Calcium signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa04072Phospholipase D signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04150mTOR signaling pathway
hsa04510Focal adhesion
hsa04540Gap junction
hsa04650Natural killer cell mediated cytotoxicity
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04670Leukocyte transendothelial migration
hsa04911Insulin secretion
hsa04929GnRH secretion
hsa04912GnRH signaling pathway
hsa04921Oxytocin signaling pathway
hsa04926Relaxin signaling pathway
hsa04918Thyroid hormone synthesis
hsa04919Thyroid hormone signaling pathway
hsa04928Parathyroid hormone synthesis, secretion and action
hsa04916Melanogenesis
hsa04925Aldosterone synthesis and secretion
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04960Aldosterone-regulated sodium reabsorption
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04724Glutamatergic synapse
hsa04727GABAergic synapse
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa04726Serotonergic synapse
hsa04720Long-term potentiation
hsa04730Long-term depression
hsa04723Retrograde endocannabinoid signaling
hsa04750Inflammatory mediator regulation of TRP channels
hsa04360Axon guidance
hsa04713Circadian entrainment
hsa05200Pathways in cancer
hsa05206MicroRNAs in cancer
hsa05205Proteoglycans in cancer
hsa05231Choline metabolism in cancer
hsa05225Hepatocellular carcinoma
hsa05214Glioma
hsa05223Non-small cell lung cancer
hsa05031Amphetamine addiction
hsa05032Morphine addiction
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05110Vibrio cholerae infection
hsa05170Human immunodeficiency virus 1 infection
hsa05164Influenza A
hsa05161Hepatitis B
hsa05163Human cytomegalovirus infection
hsa05146Amoebiasis
hsa05143African trypanosomiasis
hsa01521EGFR tyrosine kinase inhibitor resistance
hsa05200Pathways in cancer
hsa04151PI3K-Akt signaling pathway
hsa04928Parathyroid hormone synthesis, secretion and action
hsa04728Dopaminergic synapse
hsa04261Adrenergic signaling in cardiomyocytes
hsa04010MAPK signaling pathway
hsa05163Human cytomegalovirus infection
hsa04911Insulin secretion
hsa04750Inflammatory mediator regulation of TRP channels
hsa04921Oxytocin signaling pathway
hsa04020Calcium signaling pathway
hsa04725Cholinergic synapse
hsa04270Vascular smooth muscle contraction
hsa05206MicroRNAs in cancer
hsa04015Rap1 signaling pathway
hsa04970Salivary secretion
hsa04925Aldosterone synthesis and secretion
hsa04713Circadian entrainment
hsa04935Growth hormone synthesis, secretion and action
hsa04066HIF-1 signaling pathway
hsa05032Morphine addiction
hsa04723Retrograde endocannabinoid signaling
hsa04919Thyroid hormone signaling pathway
hsa04071Sphingolipid signaling pathway
hsa05031Amphetamine addiction
hsa04072Phospholipase D signaling pathway
hsa04310Wnt signaling pathway
hsa04014Ras signaling pathway
hsa04918Thyroid hormone synthesis
hsa05225Hepatocellular carcinoma
hsa05205Proteoglycans in cancer
hsa04916Melanogenesis
hsa05170Human immunodeficiency virus 1 infection
hsa04972Pancreatic secretion
hsa04926Relaxin signaling pathway
hsa04727GABAergic synapse
hsa05223Non-small cell lung cancer
hsa04150mTOR signaling pathway
hsa05110Vibrio cholerae infection
hsa05161Hepatitis B
hsa04070Phosphatidylinositol signaling system
hsa04510Focal adhesion
hsa04666Fc gamma R-mediated phagocytosis
hsa05214Glioma
hsa04726Serotonergic synapse
hsa05146Amoebiasis
hsa04971Gastric acid secretion
hsa04360Axon guidance
hsa04540Gap junction
hsa04720Long-term potentiation
hsa04929GnRH secretion
hsa04912GnRH signaling pathway
hsa04724Glutamatergic synapse
hsa01521EGFR tyrosine kinase inhibitor resistance
hsa04730Long-term depression
hsa04670Leukocyte transendothelial migration
hsa04370VEGF signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04012ErbB signaling pathway
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05231Choline metabolism in cancer
hsa04664Fc epsilon RI signaling pathway
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa05164Influenza A
hsa04960Aldosterone-regulated sodium reabsorption
hsa05143African trypanosomiasis

Diseases

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Associated diseases References
Cancer (breast) GAD: 19454617
Esophageal adenocarcinoma GAD: 20453000
Hepatopulmonary syndrome GAD: 20346360
Asthma GAD: 19576566
Multiple sclerosis GAD: 18563468
Obesity GAD: 20816195
Schizophrenia GAD: 19786960
Psychological disorders GAD: 19086053
Involved in regulation of human sperm capacitation MIK: 8495779
May be involved in some events of spermatozoa differentiation and, eventually, in the fertilization process MIK: 9157010
Spermatogenesis progressed normally but that mature sperm had defective forward motility MIK: 11875122
Cryptorchidism MIK: 28606200
Involved in regulation of human sperm capacitation MIK: 8495779
May be involved in some events of spermatozoa differentiation and, eventually, in the fertilization process MIK: 9157010
Spermatogenesis progressed normally but that mature sperm had defective forward motility MIK: 11875122
Spermatogenic defects MIK: 31037746

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
11875122 Spermatoge
nesis prog
ressed nor
mally but
that matur
e sperm ha
d defectiv
e forward
motility

Male infertility
Show abstract
9157010 May be inv
olved in s
ome events
of sperma
tozoa diff
erentiatio
n and, eve
ntually, i
n the fert
ilization
process

Male infertility
Show abstract
8495779 Involved i
n regulati
on of huma
n sperm ca
pacitation

Male infertility
Show abstract
28606200 Cryptorchi
dism
Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
 Male infertility MeDIP-Seq
 Show abstract
31037746 Spermatoge
nic defect
s
28 men with az
oospermia
 Male infertility Microarray
 Show abstract