• Gene id: 55753

Gene Summary

• Gene Symbol: OGDHL   Gene   UCSC   Ensembl
• Gene name: oxoglutarate dehydrogenase L
• Alternate names: 2-oxoglutarate dehydrogenase-like, mitochondrial, 2-oxoglutarate dehydrogenase complex component E1-like, OGDC-E1-like, alpha-ketoglutarate dehydrogenase-like, oxoglutarate dehydrogenase like,
• Gene location: 10q11.23 (49762378: 49734640)     Exons: 24     NC_000010.11
• Gene summary(Entrez): The protein encoded by this gene is similar to oxoglutarate dehydrogenase (OGDH) of the OGDH complex, which degrades glucose and glutamate. This gene encodes several isoforms, including some that appear to localize to mitochondria. The encoded protein dow
• OMIM: 617998

Protein Summary

• Protein general information: Q9ULD0  
  • Name: 2 oxoglutarate dehydrogenase like, mitochondrial (EC 1.2.4. ) (2 oxoglutarate dehydrogenase complex component E1 like) (OGDC E1 like) (Alpha ketoglutarate dehydrogenase like)
  • Length: 1010  
  • Mass: 114481
• Sequence:

  MSQLRLLPSRLGVQAARLLAAHDVPVFGWRSRSSGPPATFPSSKGGGGSSYMEEMYFAWLENPQSVHKSWDSFFR
  EASEEAFSGSAQPRPPSVVHESRSAVSSRTKTSKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSFVPS
  DLITTIDKLAFYDLQEADLDKEFQLPTTTFIGGSENTLSLREIIRRLENTYCQHIGLEFMFINDVEQCQWIRQKF
  ETPGVMQFSSEEKRTLLARLVRSMRFEDFLARKWSSEKRFGLEGCEVMIPALKTIIDKSSEMGIENVILGMPHRG
  RLNVLANVIRKDLEQIFCQFDPKLEAADEGSGDVKYHLGMYHERINRVTNRNITLSLVANPSHLEAVDPVVQGKT
  KAEQFYRGDAQGKKVMSILVHGDAAFAGQGVVYETFHLSDLPSYTTNGTVHVVVNNQIGFTTDPRMARSSPYPTD
  VARVVNAPIFHVNADDPEAVIYVCSVAAEWRNTFNKDVVVDLVCYRRRGHNEMDEPMFTQPLMYKQIHRQVPVLK
  KYADKLIAEGTVTLQEFEEEIAKYDRICEEAYGRSKDKKILHIKHWLDSPWPGFFNVDGEPKSMTCPATGIPEDM
  LTHIGSVASSVPLEDFKIHTGLSRILRGRADMTKNRTVDWALAEYMAFGSLLKEGIHVRLSGQDVERGTFSHRHH
  VLHDQEVDRRTCVPMNHLWPDQAPYTVCNSSLSEYGVLGFELGYAMASPNALVLWEAQFGDFHNTAQCIIDQFIS
  TGQAKWVRHNGIVLLLPHGMEGMGPEHSSARPERFLQMSNDDSDAYPAFTKDFEVSQLYDCNWIVVNCSTPANYF
  HVLRRQILLPFRKPLIIFTPKSLLRHPEAKSSFDQMVSGTSFQRVIPEDGAAARAPEQVQRLIFCTGKVYYDLVK
  ERSSQDLEEKVAITRLEQISPFPFDLIKQEAEKYPGAELAWCQEEHKNMGYYDYISPRFMTILRRARPIWYVGRD
  PAAAPATGNRNTHLVSLKKFLDTAFNLQAFEGKTF

• Structural information:
  • Interpro: IPR032106  IPR011603  IPR001017  IPR031717  IPR042179   IPR029061  IPR005475  
  • DIP: 61552
  • STRING: ENSP00000363216
• Other Databases: GeneCards:  OGDHL  Malacards:  OGDHL

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity	IBA	molecular function
GO:0006099	tricarboxylic acid cycle	IBA	biological process
GO:0005739	mitochondrion	IBA	cellular component
GO:0045252	oxoglutarate dehydrogenase complex	IBA	cellular component
GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity	IEA	molecular function
GO:0006099	tricarboxylic acid cycle	IEA	biological process
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	IEA	molecular function
GO:0030976	thiamine pyrophosphate binding	IEA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0006096	glycolytic process	IEA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005759	mitochondrial matrix	IEA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa01200	Carbon metabolism
hsa00020	Citrate cycle

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881