• Gene id: 55717

Gene Summary

• Gene Symbol: WDR11   Gene   UCSC   Ensembl
• Aliases: BRWD2, DR11, HH14, SRI1, WDR15
• Gene name: WD repeat domain 11
• Alternate names: WD repeat-containing protein 11, WD repeat domain 15, WD repeat-containing protein 15, bromodomain and WD repeat-containing protein 2, sensitization to ricin complex subunit 1,
• Gene location: 10q26.12 (120851174: 120909525)     Exons: 30     NC_000010.11
• Gene summary(Entrez): This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein com
• OMIM: 606417

Protein Summary

• Protein general information: Q9BZH6  
  • Name: WD repeat containing protein 11 (Bromodomain and WD repeat containing protein 2) (WD repeat containing protein 15)
  • Length: 1224  
  • Mass: 136,685
• Sequence:

  MLPYTVNFKVSARTLTGALNAHNKAAVDWGWQGLIAYGCHSLVVVIDSITAQTLQVLEKHKADVVKVKWARENYH
  HNIGSPYCLRLASADVNGKIIVWDVAAGVAQCEIQEHAKPIQDVQWLWNQDASRDLLLAIHPPNYIVLWNADTGT
  KLWKKSYADNILSFSFDPFDPSHLTLLTSEGIVFISDFSPSKPPSGPGKKVYISSPHSSPAHNKLATATGAKKAL
  NKVKILITQEKPSAEFITLNDCLQLAYLPSKRNHMLLLYPREILILDLEVNQTVGVIAIERTGVPFLQVIPCFQR
  DGLFCLHENGCITLRVRRSYNNIFTTSNEEPDPDPVQELTYDLRSQCDAIRVTKTVRPFSMVCCPVNENAAALVV
  SDGRVMIWELKSAVCNRNSRNSSSGVSPLYSPVSFCGIPVGVLQNKLPDLSLDNMIGQSAIAGEEHPRGSILREV
  HLKFLLTGLLSGLPAPQFAIRMCPPLTTKNIKMYQPLLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTS
  LTSFLSFATSTPNNMGLVRNELQLVDLPTGRSIAFRGERGNDESAIEMIKVSHLKQYLAVVFRDKPLELWDVRTC
  TLLREMSKNFPTITALEWSPSHNLKSLRKKQLATREAMARQTVVSDTELSIVESSVISLLQEAESKSELSQNISA
  REHFVFTDIDGQVYHLTVEGNSVKDSARIPPDGSMGSITCIAWKGDTLVLGDMDGNLNFWDLKGRVSRGIPTHRS
  WVRKIRFAPGKGNQKLIAMYNDGAEVWDTKEVQMVSSLRSGRNVTFRILDVDWCTSDKVILASDDGCIRVLEMSM
  KSACFRMDEQELTEPVWCPYLLVPRASLALKAFLLHQPWNGQYSLDISHVDYPENEEIKNLLQEQLNSLSNDIKK
  LLLDPEFTLLQRCLLVSRLYGDESELHFWTVAAHYLHSLSQEKSASTTAPKEAAPRDKLSNPLDICYDVLCENAY
  FQKFQLERVNLQEVKRSTYDHTRKCTDQLLLLGQTDRAVQLLLETSADNQHYYCDSLKACLVTTVTSSGPSQSTI
  KLVATNMIANGKLAEGVQLLCLIDKAADACRYLQTYGEWNRAAWLAKVRLNPEECADVLRRWVDHLCSPQVNQKS
  KALLVLLSLGCFFSVAETLHSMRYFDRAALFVEACLKYGAFEVTEDTEKLITAIYADYARSLKNLGFKQGAVLFA
  SKAGAAGKDLLNELESPKEEPIEE

• Structural information:
  • Interpro: IPR015943  IPR001680  IPR019775  IPR036322  
  • Prosite: PS00678
  • STRING: ENSP00000263461
• Other Databases: GeneCards:  WDR11  Malacards:  WDR11

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005765	lysosomal membrane	IDA	cellular component
GO:0015630	microtubule cytoskeleton	IDA	cellular component
GO:0016020	membrane	IDA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005765	lysosomal membrane	IDA	cellular component
GO:0015630	microtubule cytoskeleton	IDA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016020	membrane	IDA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005765	lysosomal membrane	IDA	cellular component
GO:0015630	microtubule cytoskeleton	IDA	cellular component
GO:0016020	membrane	IDA	cellular component

Diseases

Associated diseases	References
Asthma	GAD: 22424883
Alzheimer's disease	GAD: 16385451
Hypogonadotropic hypogonadism	KEGG: H00255
Hypogonadotropic hypogonadism	MIK: 20887964
Kallmann syndrome (KS)	MIK: 20887964
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Idiopathic hypogonadotropic hypogonadism	MIK: 20887964
Kallmann syndrome	MIK: 20887964
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
26114870	idiopathic hypogonadotropic hypogonadism				Male infertility	FGFR2 NSMCE4A WDR11 and ATE1
20887964	Idiopathic hypogonadotropic hypogonadism, Kallmann syndrome	A435T, R448Q, and H690Q		6 idiopathic hypogonadotropic hypogonadism, Kallmann syndrome	Male infertility, Female infertility	EMX1 WDR11
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq