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Gene id 5568
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary

Gene Symbol PRKACG   Gene   UCSC   Ensembl
Aliases BDPLT19, KAPG, PKACg
Gene name protein kinase cAMP-activated catalytic subunit gamma
Alternate names cAMP-dependent protein kinase catalytic subunit gamma, PKA C-gamma, protein kinase, cAMP-dependent, catalytic, gamma, protein kinase, cAMP-dependent, gamma catalytic subunit, serine(threonine) protein kinase,
Gene location 9q21.11 (69014112: 69012503)     Exons: 1     NC_000009.12
Gene summary(Entrez) Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for
OMIM 176893

Protein Summary

Protein general information P22612  

Name: cAMP dependent protein kinase catalytic subunit gamma (PKA C gamma) (EC 2.7.11.11)

Length: 351  Mass: 40434

Tissue specificity: Testis specific. But important tissues such as brain and ovary have not been analyzed for the content of transcript.

Sequence MGNAPAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKIL
NKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQ
VVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWAL
GVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFAT
TSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEELRISINEKCAKEFSEF
Structural information
Protein Domains
(44..29-)
(/note="Protein-kinase)
(/evidence="ECO:0000255|PROSITE-ProRule:PRU00159-)
(299..35-)
(/note="AGC-kinase-C-terminal")
Interpro:  IPR000961  IPR011009  IPR039084  IPR000719  IPR017441  
IPR008271  
Prosite:   PS51285 PS00107 PS50011 PS00108
STRING:   ENSP00000366488
Other Databases GeneCards:  PRKACG  Malacards:  PRKACG

Gene ontology

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GO accessionTerm nameEvidence codeGo category
GO:0010737 protein kinase A signalin
g
IBA biological process
GO:0005634 nucleus
IBA cellular component
GO:0004672 protein kinase activity
IEA molecular function
GO:0004674 protein serine/threonine
kinase activity
IEA molecular function
GO:0005524 ATP binding
IEA molecular function
GO:0006468 protein phosphorylation
IEA biological process
GO:0016740 transferase activity
IEA molecular function
GO:0016301 kinase activity
IEA molecular function
GO:0016310 phosphorylation
IEA biological process
GO:0005524 ATP binding
IEA molecular function
GO:0004674 protein serine/threonine
kinase activity
IEA molecular function
GO:0000166 nucleotide binding
IEA molecular function
GO:0004691 cAMP-dependent protein ki
nase activity
TAS molecular function
GO:0008584 male gonad development
TAS biological process
GO:0007283 spermatogenesis
TAS biological process
GO:0004679 AMP-activated protein kin
ase activity
IEA molecular function
GO:0004691 cAMP-dependent protein ki
nase activity
IEA molecular function
GO:0003091 renal water homeostasis
TAS biological process
GO:0034380 high-density lipoprotein
particle assembly
TAS biological process
GO:0071377 cellular response to gluc
agon stimulus
TAS biological process
GO:0002223 stimulatory C-type lectin
receptor signaling pathw
ay
TAS biological process
GO:0005654 nucleoplasm
TAS cellular component
GO:0005654 nucleoplasm
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0007596 blood coagulation
TAS biological process
GO:0034199 activation of protein kin
ase A activity
TAS biological process
GO:0097546 ciliary base
TAS cellular component
GO:0097546 ciliary base
TAS cellular component
GO:0045171 intercellular bridge
IDA cellular component
GO:0005829 cytosol
IDA cellular component

KEGG pathways

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Pathway idPathway name
hsa05200Pathways in cancer
hsa05165Human papillomavirus infection
hsa04010MAPK signaling pathway
hsa05012Parkinson disease
hsa04714Thermogenesis
hsa04014Ras signaling pathway
hsa04024cAMP signaling pathway
hsa05166Human T-cell leukemia virus 1 infection
hsa05163Human cytomegalovirus infection
hsa04020Calcium signaling pathway
hsa04062Chemokine signaling pathway
hsa05034Alcoholism
hsa05203Viral carcinogenesis
hsa05205Proteoglycans in cancer
hsa04310Wnt signaling pathway
hsa04530Tight junction
hsa04723Retrograde endocannabinoid signaling
hsa04261Adrenergic signaling in cardiomyocytes
hsa04934Cushing syndrome
hsa04140Autophagy - animal
hsa04740Olfactory transduction
hsa04921Oxytocin signaling pathway
hsa04371Apelin signaling pathway
hsa04910Insulin signaling pathway
hsa04728Dopaminergic synapse
hsa04724Glutamatergic synapse
hsa04270Vascular smooth muscle contraction
hsa04114Oocyte meiosis
hsa04611Platelet activation
hsa04926Relaxin signaling pathway
hsa04725Cholinergic synapse
hsa04935Growth hormone synthesis, secretion and action
hsa04919Thyroid hormone signaling pathway
hsa04915Estrogen signaling pathway
hsa04726Serotonergic synapse
hsa04922Glucagon signaling pathway
hsa04916Melanogenesis
hsa05032Morphine addiction
hsa04727GABAergic synapse
hsa04713Circadian entrainment
hsa04925Aldosterone synthesis and secretion
hsa04928Parathyroid hormone synthesis, secretion and action
hsa05414Dilated cardiomyopathy
hsa04750Inflammatory mediator regulation of TRP channels
hsa04970Salivary secretion
hsa04914Progesterone-mediated oocyte maturation
hsa04912GnRH signaling pathway
hsa04911Insulin secretion
hsa04540Gap junction
hsa04211Longevity regulating pathway
hsa01522Endocrine resistance
hsa05146Amoebiasis
hsa04971Gastric acid secretion
hsa04918Thyroid hormone synthesis
hsa04742Taste transduction
hsa04720Long-term potentiation
hsa05031Amphetamine addiction
hsa04924Renin secretion
hsa04976Bile secretion
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04927Cortisol synthesis and secretion
hsa05110Vibrio cholerae infection
hsa04213Longevity regulating pathway - multiple species
hsa05030Cocaine addiction
hsa04340Hedgehog signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04962Vasopressin-regulated water reabsorption
hsa04913Ovarian steroidogenesis
hsa05020Prion diseases
P06959CCKR signaling map
Associated diseases References
Macrothrombocytopenia KEGG:H01740
Macrothrombocytopenia KEGG:H01740
Teratozoospermia MIK: 17327269

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
17327269 Teratozoos
permia

19 (6 controls
, 13 cases)
Male infertility GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
Show abstract