• Gene id: 55679

Gene Summary

• Gene Symbol: LIMS2   Gene   UCSC   Ensembl
• Aliases: LGMD2W, MDRCMTT, PINCH-2, PINCH2
• Gene name: LIM zinc finger domain containing 2
• Alternate names: LIM and senescent cell antigen-like-containing domain protein 2, ILK-binding protein, LIM and senescent cell antigen-like domains 2, LIM-type zinc finger domains 2, particularly interesting new Cys-His protein 2,
• Gene location: 2q14.3 (127681785: 127638380)     Exons: 18     NC_000002.12
• Gene summary(Entrez): This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each do
• OMIM: 610615

Protein Summary

• Protein general information: Q7Z4I7  
  • Name: LIM and senescent cell antigen like containing domain protein 2 (LIM like protein 2) (Particularly interesting new Cys His protein 2) (PINCH 2)
  • Length: 341  
  • Mass: 38916
• Sequence:

  MTGSNMSDALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPC
  CGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGKYICQRCHLVIDEQ
  PLMFRSDAYHPDHFNCTHCGKELTAEARELKGELYCLPCHDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCA
  KCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFD
  MKPVCKRCYEKFPLELKKRLKKLSELTSRKAQPKATDLNSA

• Structural information:
  • Protein Domains: (13..7-)
    1 (/note="LIM-zinc-binding)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00125-)
    (76..13-)
    2 (/note="LIM-zinc-binding)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00125-)
    (138..19-)
    3 (/note="LIM-zinc-binding)
    (/evidence="ECO:00-)
  • Interpro: IPR017351  IPR001781  
  • Prosite: PS00478 PS50023
  • PDB: 3IXE
  • PDBsum: 3IXE
  • STRING: ENSP00000326888
• Other Databases: GeneCards:  LIMS2  Malacards:  LIMS2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:2001046	positive regulation of integrin-mediated signaling pathway	IBA	biological process
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	IBA	biological process
GO:0098609	cell-cell adhesion	IBA	biological process
GO:0045216	cell-cell junction organization	IBA	biological process
GO:0005911	cell-cell junction	IBA	cellular component
GO:0005925	focal adhesion	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0046872	metal ion binding	IEA	molecular function
GO:0030054	cell junction	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0034329	cell junction assembly	TAS	biological process
GO:0043066	negative regulation of apoptotic process	IEA	biological process
GO:0045216	cell-cell junction organization	IEA	biological process
GO:0050680	negative regulation of epithelial cell proliferation	IEA	biological process
GO:0098609	cell-cell adhesion	IEA	biological process
GO:2000178	negative regulation of neural precursor cell proliferation	IEA	biological process
GO:2001046	positive regulation of integrin-mediated signaling pathway	IEA	biological process
GO:0005925	focal adhesion	IEA	cellular component
GO:2000346	negative regulation of hepatocyte proliferation	IEA	biological process
GO:0005925	focal adhesion	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005925	focal adhesion	IDA	cellular component
GO:0005925	focal adhesion	HDA	cellular component

Diseases

Associated diseases	References
Limb-girdle muscular dystrophy	KEGG:H00593
Limb-girdle muscular dystrophy	KEGG:H00593
Cryptorchidism	MIK: 28606200
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray