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Gene id 5566
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary

Gene Symbol PRKACA   Gene   UCSC   Ensembl
Aliases PKACA, PPNAD4
Gene name protein kinase cAMP-activated catalytic subunit alpha
Alternate names cAMP-dependent protein kinase catalytic subunit alpha, PKA C-alpha, protein kinase A catalytic subunit, protein kinase, cAMP-dependent, alpha catalytic subunit, protein kinase, cAMP-dependent, catalytic, alpha,
Gene location 19p13.12 (14117761: 14091687)     Exons: 12     NC_000004.12
Gene summary(Entrez) This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dime
OMIM 601639

Protein Summary

Gene ontology

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GO accessionTerm nameEvidence codeGo category

KEGG pathways

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Pathway idPathway name
hsa04020Calcium signaling pathway
hsa04024cAMP signaling pathway
hsa04140Autophagy - animal
hsa04114Oocyte meiosis
hsa04530Tight junction
hsa04540Gap junction
hsa04611Platelet activation
hsa04062Chemokine signaling pathway
hsa04911Insulin secretion
hsa04910Insulin signaling pathway
hsa04922Glucagon signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04912GnRH signaling pathway
hsa04913Ovarian steroidogenesis
hsa04915Estrogen signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04921Oxytocin signaling pathway
hsa04926Relaxin signaling pathway
hsa04918Thyroid hormone synthesis
hsa04919Thyroid hormone signaling pathway
hsa04928Parathyroid hormone synthesis, secretion and action
hsa04916Melanogenesis
hsa04924Renin secretion
hsa04925Aldosterone synthesis and secretion
hsa04927Cortisol synthesis and secretion
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04976Bile secretion
hsa04962Vasopressin-regulated water reabsorption
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04724Glutamatergic synapse
hsa04727GABAergic synapse
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa04726Serotonergic synapse
hsa04720Long-term potentiation
hsa04723Retrograde endocannabinoid signaling
hsa04740Olfactory transduction
hsa04742Taste transduction
hsa04750Inflammatory mediator regulation of TRP channels
hsa04211Longevity regulating pathway
hsa04213Longevity regulating pathway - multiple species
hsa04713Circadian entrainment
hsa04714Thermogenesis
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05203Viral carcinogenesis
hsa05012Parkinson disease
hsa05020Prion diseases
hsa05030Cocaine addiction
hsa05031Amphetamine addiction
hsa05032Morphine addiction
hsa05034Alcoholism
hsa05414Dilated cardiomyopathy
hsa04934Cushing syndrome
hsa05110Vibrio cholerae infection
hsa05166Human T-cell leukemia virus 1 infection
hsa05163Human cytomegalovirus infection
hsa05165Human papillomavirus infection
hsa05146Amoebiasis
hsa01522Endocrine resistance
hsa05200Pathways in cancer
hsa04915Estrogen signaling pathway
hsa05166Human T-cell leukemia virus 1 infection
hsa04928Parathyroid hormone synthesis, secretion and action
hsa04728Dopaminergic synapse
hsa04714Thermogenesis
hsa04261Adrenergic signaling in cardiomyocytes
hsa04010MAPK signaling pathway
hsa05203Viral carcinogenesis
hsa04024cAMP signaling pathway
hsa05163Human cytomegalovirus infection
hsa04911Insulin secretion
hsa04750Inflammatory mediator regulation of TRP channels
hsa04921Oxytocin signaling pathway
hsa04020Calcium signaling pathway
hsa04725Cholinergic synapse
hsa04270Vascular smooth muscle contraction
hsa05012Parkinson disease
hsa04970Salivary secretion
hsa04925Aldosterone synthesis and secretion
hsa04713Circadian entrainment
hsa05165Human papillomavirus infection
hsa04935Growth hormone synthesis, secretion and action
hsa05032Morphine addiction
hsa04723Retrograde endocannabinoid signaling
hsa04211Longevity regulating pathway
hsa04910Insulin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa05031Amphetamine addiction
hsa04371Apelin signaling pathway
hsa04611Platelet activation
hsa04310Wnt signaling pathway
hsa04014Ras signaling pathway
hsa04918Thyroid hormone synthesis
hsa04976Bile secretion
hsa05034Alcoholism
hsa04114Oocyte meiosis
hsa04530Tight junction
hsa05205Proteoglycans in cancer
hsa04916Melanogenesis
hsa04926Relaxin signaling pathway
hsa04727GABAergic synapse
hsa04922Glucagon signaling pathway
hsa04140Autophagy - animal
hsa05110Vibrio cholerae infection
hsa04962Vasopressin-regulated water reabsorption
hsa04062Chemokine signaling pathway
hsa04726Serotonergic synapse
hsa05146Amoebiasis
hsa04971Gastric acid secretion
hsa04934Cushing syndrome
hsa04742Taste transduction
hsa04923Regulation of lipolysis in adipocytes
hsa04213Longevity regulating pathway - multiple species
hsa04540Gap junction
hsa04927Cortisol synthesis and secretion
hsa04720Long-term potentiation
hsa01522Endocrine resistance
hsa04912GnRH signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04724Glutamatergic synapse
hsa05030Cocaine addiction
hsa05414Dilated cardiomyopathy
hsa04340Hedgehog signaling pathway
hsa04913Ovarian steroidogenesis
hsa04924Renin secretion
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04740Olfactory transduction
hsa05020Prion diseases
Associated diseases References
Cushing's syndrome KEGG: H01431
Bilateral macronodular adrenal hyperplasia KEGG: H02049
Associated with sperm acrosome reaction MIK: 10684828
Male factor infertility MIK: 15340140
Assocaited with sperm acrosome reaction MIK: 10684828
Male infertility MIK: 15340140
Teratozoospermia MIK: 17327269

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
15340140 Male infer
tility


Male infertility
Show abstract
10684828 Assocaited
with sper
m acrosome
reaction


Male infertility
Show abstract
17327269 Teratozoos
permia

19 (6 controls
, 13 cases)
Male infertility GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
Show abstract