• Gene id: 55585

Gene Summary

• Gene Symbol: UBE2Q1   Gene   UCSC   Ensembl
• Aliases: GTAP, NICE-5, NICE5, PRO3094, UBE2Q
• Gene name: ubiquitin conjugating enzyme E2 Q1
• Alternate names: ubiquitin-conjugating enzyme E2 Q1, E2 ubiquitin-conjugating enzyme Q1, galactosyl transferase-associated protein, protein NICE-5, ubiquitin carrier protein Q1, ubiquitin conjugating enzyme E2Q family member 1, ubiquitin-conjugating enzyme E2Q (putative) 1, ubiq,
• Gene location: 1q21.3 (15585050: 15571698)     Exons: 7     NC_000001.11
• Gene summary(Entrez): The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjuga
• OMIM: 617429

Protein Summary

• Protein general information: Q7Z7E8  
  • Name: Ubiquitin conjugating enzyme E2 Q1 (EC 2.3.2.23) (E2 ubiquitin conjugating enzyme Q1) (Protein NICE 5) (Ubiquitin carrier protein Q1) (Ubiquitin protein ligase Q1)
  • Length: 422  
  • Mass: 46127
  • Tissue specificity: Widely expressed. {ECO
• Sequence:

  MQQPQPQGQQQPGPGQQLGGQGAAPGAGGGPGGGPGPGPCLRRELKLLESIFHRGHERFRIASACLDELSCEFLL
  AGAGGAGAGAAPGPHLPPRGSVPGDPVRIHCNITESYPAVPPIWSVESDDPNLAAVLERLVDIKKGNTLLLQHLK
  RIISDLCKLYNLPQHPDVEMLDQPLPAEQCTQEDVSSEDEDEEMPEDTEDLDHYEMKEEEPAEGKKSEDDGIGKE
  NLAILEKIKKNQRQDYLNGAVSGSVQATDRLMKELRDIYRSQSFKGGNYAVELVNDSLYDWNVKLLKVDQDSALH
  NDLQILKEKEGADFILLNFSFKDNFPFDPPFVRVVSPVLSGGYVLGGGAICMELLTKQGWSSAYSIESVIMQISA
  TLVKGKARVQFGANKSQYSLTRAQQSYKSLVQIHEKNGWYTPPKEDG

• Structural information:
  • Interpro: IPR000608  IPR016135  
  • Prosite: PS50127
  • PDB: 2QGX
  • PDBsum: 2QGX
  • STRING: ENSP00000292211
• Other Databases: GeneCards:  UBE2Q1  Malacards:  UBE2Q1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000209	protein polyubiquitination	IBA	biological process
GO:0005634	nucleus	IBA	cellular component
GO:0061631	ubiquitin conjugating enzyme activity	IBA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0042995	cell projection	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0061631	ubiquitin conjugating enzyme activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0009566	fertilization	IEA	biological process
GO:0007617	mating behavior	IEA	biological process
GO:0007566	embryo implantation	IEA	biological process
GO:0070459	prolactin secretion	IEA	biological process
GO:0061631	ubiquitin conjugating enzyme activity	IEA	molecular function
GO:0061458	reproductive system development	IEA	biological process
GO:0001967	suckling behavior	IEA	biological process
GO:0030175	filopodium	IEA	cellular component
GO:0005829	cytosol	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0016567	protein ubiquitination	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04120	Ubiquitin mediated proteolysis

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)