• Gene id: 55558

Gene Summary

• Gene Symbol: PLXNA3   Gene   UCSC   Ensembl
• Aliases: 6.3, HSSEXGENE, PLXN3, PLXN4, XAP-6
• Gene name: plexin A3
• Alternate names: plexin-A3, Sex chromosome X transmembrane protein of HGF receptor family 3, plexin-4, semaphorin receptor SEX,
• Gene location: Xq28 (154458280: 154477778)     Exons: 33     NC_000023.11
• Gene summary(Entrez): This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important
• OMIM: 612307

Protein Summary

• Protein general information: P51805  
  • Name: Plexin A3 (Plexin 4) (Semaphorin receptor SEX)
  • Length: 1871  
  • Mass: 207703
• Sequence:

  MPSVCLLLLLFLAVGGALGNRPFRAFVVTDTTLTHLAVHRVTGEVFVGAVNRVFKLAPNLTELRAHVTGPVEDNA
  RCYPPPSMRVCAHRLAPVDNINKLLLIDYAARRLVACGSIWQGICQFLRLDDLFKLGEPHHRKEHYLSGAQEPDS
  MAGVIVEQGQGPSKLFVGTAVDGKSEYFPTLSSRKLISDEDSADMFSLVYQDEFVSSQIKIPSDTLSLYPAFDIY
  YIYGFVSASFVYFLTLQLDTQQTLLDTAGEKFFTSKIVRMCAGDSEFYSYVEFPIGCSWRGVEYRLVQSAHLAKP
  GLLLAQALGVPADEDVLFTIFSQGQKNRASPPRQTILCLFTLSNINAHIRRRIQSCYRGEGTLALPWLLNKELPC
  INTPMQINGNFCGLVLNQPLGGLHVIEGLPLLADSTDGMASVAAYTYRQHSVVFIGTRSGSLKKVRVDGFQDAHL
  YETVPVVDGSPILRDLLFSPDHRHIYLLSEKQVSQLPVETCEQYQSCAACLGSGDPHCGWCVLRHRCCREGACLG
  ASAPHGFAEELSKCVQVRVRPNNVSVTSPGVQLTVTLHNVPDLSAGVSCAFEAAAENEAVLLPSGELLCPSPSLQ
  ELRALTRGHGATRTVRLQLLSKETGVRFAGADFVFYNCSVLQSCMSCVGSPYPCHWCKYRHTCTSRPHECSFQEG
  RVHSPEGCPEILPSGDLLIPVGVMQPLTLRAKNLPQPQSGQKNYECVVRVQGRQQRVPAVRFNSSSVQCQNASYS
  YEGDEHGDTELDFSVVWDGDFPIDKPPSFRALLYKCWAQRPSCGLCLKADPRFNCGWCISEHRCQLRTHCPAPKT
  NWMHLSQKGTRCSHPRITQIHPLVGPKEGGTRVTIVGDNLGLLSREVGLRVAGVRCNSIPAEYISAERIVCEMEE
  SLVPSPPPGPVELCVGDCSADFRTQSEQVYSFVTPTFDQVSPSRGPASGGTRLTISGSSLDAGSRVTVTVRDSEC
  QFVRRDAKAIVCISPLSTLGPSQAPITLAIDRANISSPGLIYTYTQDPTVTRLEPTWSIINGSTAITVSGTHLLT
  VQEPRVRAKYRGIETTNTCQVINDTAMLCKAPGIFLGRPQPRAQGEHPDEFGFLLDHVQTARSLNRSSFTYYPDP
  SFEPLGPSGVLDVKPGSHVVLKGKNLIPAAAGSSRLNYTVLIGGQPCSLTVSDTQLLCDSPSQTGRQPVMVLVGG
  LEFWLGTLHISAERALTLPAMMGLAAGGGLLLLAITAVLVAYKRKTQDADRTLKRLQLQMDNLESRVALECKEAF
  AELQTDINELTNHMDEVQIPFLDYRTYAVRVLFPGIEAHPVLKELDTPPNVEKALRLFGQLLHSRAFVLTFIHTL
  EAQSSFSMRDRGTVASLTMVALQSRLDYATGLLKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLH
  KFLKECAGEPLFLLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVCPENEGSAQVPVKVLNC
  DSITQAKDKLLDTVYKGIPYSQRPKAEDMDLEWRQGRMTRIILQDEDVTTKIECDWKRLNSLAHYQVTDGSLVAL
  VPKQVSAYNMANSFTFTRSLSRYESLLRTASSPDSLRSRAPMITPDQETGTKLWHLVKNHDHADHREGDRGSKMV
  SEIYLTRLLATKGTLQKFVDDLFETVFSTAHRGSALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFW
  VNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMAS
  ISDQDMDAYLVEQSRLHASDFSVLSALNELYFYVTKYRQEILTALDRDASCRKHKLRQKLEQIISLVSSDS

• Structural information:
  • Protein Domains: (20..48-)
    (/note="Sema-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00352-)
    (840..93-)
    (/note="IPT/TIG-1)
    (935..102-)
    (/note="IPT/TIG-2)
    (1023..112-)
    (/note="IPT/TIG-3)
    (1125..121-)
    (/note="IPT/TIG-4")
  • Interpro: IPR013783  IPR014756  IPR002909  IPR031148  IPR013548   IPR002165  IPR016201  IPR008936  IPR001627  IPR036352  IPR041019  IPR041362  IPR015943  
  • Prosite: PS51004
  • DIP: 57386
  • STRING: ENSP00000358696
• Other Databases: GeneCards:  PLXNA3  Malacards:  PLXNA3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0002116	semaphorin receptor complex	IBA	cellular component
GO:0005887	integral component of plasma membrane	IBA	cellular component
GO:0007162	negative regulation of cell adhesion	IBA	biological process
GO:0017154	semaphorin receptor activity	IBA	molecular function
GO:0043087	regulation of GTPase activity	IBA	biological process
GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	IBA	biological process
GO:0008360	regulation of cell shape	IBA	biological process
GO:0030334	regulation of cell migration	IBA	biological process
GO:0050772	positive regulation of axonogenesis	IBA	biological process
GO:0007165	signal transduction	IEA	biological process
GO:0017154	semaphorin receptor activity	IEA	molecular function
GO:0071526	semaphorin-plexin signaling pathway	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0021766	hippocampus development	IEA	biological process
GO:1990138	neuron projection extension	IEA	biological process
GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	IEA	biological process
GO:0097485	neuron projection guidance	IEA	biological process
GO:0051495	positive regulation of cytoskeleton organization	IEA	biological process
GO:0050919	negative chemotaxis	IEA	biological process
GO:0048843	negative regulation of axon extension involved in axon guidance	IEA	biological process
GO:0021860	pyramidal neuron development	IEA	biological process
GO:0021785	branchiomotor neuron axon guidance	IEA	biological process
GO:0021637	trigeminal nerve structural organization	IEA	biological process
GO:0021612	facial nerve structural organization	IEA	biological process
GO:0017154	semaphorin receptor activity	IEA	molecular function
GO:0007411	axon guidance	IEA	biological process
GO:0002116	semaphorin receptor complex	TAS	cellular component
GO:0071526	semaphorin-plexin signaling pathway	NAS	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0016020	membrane	TAS	cellular component
GO:0007275	multicellular organism development	TAS	biological process
GO:0004888	transmembrane signaling receptor activity	NAS	molecular function

KEGG pathways

Pathway id	Pathway name
hsa04360	Axon guidance

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq