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Gene id 55540
Gene Summary     SNPs    KEGG pathways    Diseases    PubMed    

Gene Summary

Gene Symbol IL17RB   Gene   UCSC   Ensembl
Aliases CRL4, EVI27, IL17BR, IL17RH1
Gene name interleukin 17 receptor B
Alternate names interleukin-17 receptor B, IL-17 receptor B, IL-17 receptor homolog 1, IL-17B receptor, IL-17RB, IL-17Rh1, cytokine receptor CRL4, cytokine receptor-like 4, interleukin 17 receptor homolog 1, interleukin-17B receptor,
Gene location 3p21.1 (53846549: 53867387)     Exons: 13     NC_000003.12
Gene summary(Entrez) The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL1
OMIM 605458

SNPs


rs1025689

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000003.12   g.53849695C>A
NC_000003.12   g.53849695C>G
NC_000003.12   g.53849695C>T
NC_000003.11   g.53883722C>A
NC_000003.11   g.53883722C>G
NC_000003.11   g.53883722C>T
NG_028042.1   g.1699G>T
NG_028042.1   g.1699G>C
NG_028042.1   g.1699G>A
XM_005265310.5   c.126C>

KEGG pathways

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Pathway idPathway name
hsa04060Cytokine-cytokine receptor interaction
hsa04657IL-17 signaling pathway
Associated diseases References
Cancer GAD: 18794098
Asthma GAD: 19118269
Premature ovarian insufficiency (POI) INFBASE: 24357321
Female infertility INFBASE: 24357321
Altered sperm motility MIK: 22558321

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
22558321 Altered sp
erm motili
ty
rs1025689

Male infertility
Show abstract