|
Gene id |
554213 |
| Gene Summary KEGG pathways Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
MIR449A Gene UCSC Ensembl |
|
Aliases |
MIRN449, MIRN449A, hsa-mir-449, mir-449a |
|
Gene name |
microRNA 449a |
|
Alternate names |
hsa-mir-449a, microRNA 449, |
|
Gene location |
5q11.2 (55170621: 55170531) Exons: 1 NC_000005.10
|
|
Gene summary(Entrez) |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I
|
|
OMIM |
613131 |
|
| Pathway id | Pathway name |
|---|
| hsa05206 | MicroRNAs in cancer | |
|
| Associated diseases |
References |
| Spermatogenesis defects | MIK: 26648257 |
| Maturation arrest | MIK: 26648257 |
| Cryptorchidism | MIK: 30103742 |
| Obstructive azoospermia | MIK: 30103742 |
| Male infertility | MIK: 30103742 |
| Oligoasthenozoospermia | MIK: 23312218 |
| Spermatogenic failure | MIK: 26648257 |
| Maturation failure | MIK: 26648257 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 26648257 |
Spermatoge
nic failur
e, maturat
ion failur
e
|
|
|
|
Male infertility |
miR-449a
miR-34c-5p and miR-122
|
Show abstract |
| 30103742 |
Cryptorchi
dism, Obst
ructive az
oospermia,
Male infe
rtility
|
|
|
6 (3 post-crypt
orchidopexy tes
ticular tissue
samples, 3 obst
ructive azoospe
rmia)
|
Male infertility |
Microarray microRNAs
|
Show abstract |
| 23312218 |
Oligoasthe
nozoosperm
ia
|
|
|
27 (9 normozoos
permia, 9 oligo
asthenozoosperm
ia, 9 asthenozo
ospermia)
|
Male infertility |
NGS
|
Show abstract |
|