• Gene id: 55331

Gene Summary

• Gene Symbol: ACER3   Gene   UCSC   Ensembl
• Aliases: APHC, PHCA, PLDECO
• Gene name: alkaline ceramidase 3
• Alternate names: alkaline ceramidase 3, alkCDase 3, alkaline CDase 3, alkaline dihydroceramidase SB89, alkaline phytoceramidase, phytoceramidase, alkaline,
• Gene location: 11q13.5 (76860887: 77026796)     Exons: 12     NC_000011.10
• OMIM: 617036

Protein Summary

• Protein general information: Q9NUN7  
  • Name: Alkaline ceramidase 3 (AlkCDase 3) (Alkaline CDase 3) (EC 3.5.1. ) (EC 3.5.1.23) (Alkaline dihydroceramidase SB89) (Alkaline phytoceramidase) (aPHC)
  • Length: 267  
  • Mass: 31552
  • Tissue specificity: Ubiquitously expressed. Highly expressed in placenta (PubMed
• Sequence:

  MAPAADREGYWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFGAVQSVRDGLEKRYIASYLALTVVGM
  GSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFECFKIKNSVNYHLLFTLVLFSLIVTTVYLKVKEPIFHQVMYG
  MLVFTLVLRSIYIVTWVYPWLRGLGYTSLGIFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWWHILTG
  LGSYLHILFSLYTRTLYLRYRPKVKFLFGIWPVILFEPLRKH

• Structural information:
  • Interpro: IPR008901  
  • PDB: 6G7O
  • PDBsum: 6G7O
  • STRING: ENSP00000434480
• Other Databases: GeneCards:  ACER3  Malacards:  ACER3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0071602	phytosphingosine biosynthetic process	IBA	biological process
GO:0030176	integral component of endoplasmic reticulum membrane	IBA	cellular component
GO:0005783	endoplasmic reticulum	IBA	cellular component
GO:0070774	phytoceramidase activity	IBA	molecular function
GO:0008270	zinc ion binding	IDA	molecular function
GO:0017040	N-acylsphingosine amidohydrolase activity	IDA	molecular function
GO:0005509	calcium ion binding	IDA	molecular function
GO:0017040	N-acylsphingosine amidohydrolase activity	IDA	molecular function
GO:0071633	dihydroceramidase activity	IDA	molecular function
GO:0046514	ceramide catabolic process	IDA	biological process
GO:0016021	integral component of membrane	IDA	cellular component
GO:0043067	regulation of programmed cell death	IDA	biological process
GO:0046512	sphingosine biosynthetic process	IMP	biological process
GO:0042552	myelination	IMP	biological process
GO:0046512	sphingosine biosynthetic process	IMP	biological process
GO:0017040	N-acylsphingosine amidohydrolase activity	IMP	molecular function
GO:0071633	dihydroceramidase activity	IMP	molecular function
GO:0046514	ceramide catabolic process	IMP	biological process
GO:0046514	ceramide catabolic process	IMP	biological process
GO:0070774	phytoceramidase activity	IMP	molecular function
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IEA	molecular function
GO:0006672	ceramide metabolic process	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0006665	sphingolipid metabolic process	IEA	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0006629	lipid metabolic process	IEA	biological process
GO:0102121	ceramidase activity	IEA	molecular function
GO:0017040	N-acylsphingosine amidohydrolase activity	IEA	molecular function
GO:0030148	sphingolipid biosynthetic process	TAS	biological process
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0070774	phytoceramidase activity	TAS	molecular function
GO:0046512	sphingosine biosynthetic process	IEA	biological process
GO:0070774	phytoceramidase activity	IEA	molecular function
GO:0046514	ceramide catabolic process	IEA	biological process
GO:0006954	inflammatory response	IEA	biological process
GO:0005789	endoplasmic reticulum membrane	IEA	cellular component
GO:0000139	Golgi membrane	IEA	cellular component
GO:0006665	sphingolipid metabolic process	IEA	biological process
GO:0071602	phytosphingosine biosynthetic process	IDA	biological process
GO:0071602	phytosphingosine biosynthetic process	IDA	biological process
GO:0046512	sphingosine biosynthetic process	IDA	biological process
GO:0070774	phytoceramidase activity	IDA	molecular function
GO:0030176	integral component of endoplasmic reticulum membrane	IDA	cellular component
GO:0030173	integral component of Golgi membrane	IDA	cellular component
GO:0070774	phytoceramidase activity	IDA	molecular function
GO:0008284	positive regulation of cell population proliferation	IMP	biological process

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00600	Sphingolipid metabolism

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R