• Gene id: 5532

Gene Summary

• Gene Symbol: PPP3CB   Gene   UCSC   Ensembl
• Aliases: CALNA2, CALNB, CNA2, PP2Bbeta
• Gene name: protein phosphatase 3 catalytic subunit beta
• Alternate names: serine/threonine-protein phosphatase 2B catalytic subunit beta isoform, CAM-PRP catalytic subunit, CNA beta, calcineurin A beta, calcineurin A2, calmodulin-dependent calcineurin A subunit beta isoform, protein phosphatase 2B, catalytic subunit, beta isoform, pro,
• Gene location: 10q22.2 (73496023: 73436427)     Exons: 16     NC_000010.11
• OMIM: 114106

Protein Summary

• Protein general information: P16298  
  • Name: Serine/threonine protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM PRP catalytic subunit) (Calmodulin dependent calcineurin A subunit beta isoform) (CNA beta)
  • Length: 524  
  • Mass: 59024
• Sequence:

  MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIIN
  EGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYP
  STLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLD
  RFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMY
  RKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLV
  NVLSICSDDELMTEGEDQFDGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGGR
  QTLQSATVEAIEAEKAIRGFSPPHRICSFEEAKGLDRINERMPPRKDAVQQDGFNSLNTAHATENHGTGNHTAQ

• Structural information:
  • Interpro: IPR004843  IPR029052  IPR041751  IPR006186  
  • Prosite: PS00125
  • CDD: cd07416
  • PDB: 4OR9 4ORA 4ORC
  • PDBsum: 4OR9 4ORA 4ORC
  • DIP: 52337
  • STRING: ENSP00000378306
• Other Databases: GeneCards:  PPP3CB  Malacards:  PPP3CB

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016787	hydrolase activity	IEA	molecular function
GO:0005516	calmodulin binding	IEA	molecular function
GO:0004721	phosphoprotein phosphatase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0004721	phosphoprotein phosphatase activity	IEA	molecular function
GO:0007223	Wnt signaling pathway, calcium modulating pathway	TAS	biological process
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0038095	Fc-epsilon receptor signaling pathway	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0001946	lymphangiogenesis	IEA	biological process
GO:0006470	protein dephosphorylation	IEA	biological process
GO:0017156	calcium-ion regulated exocytosis	IEA	biological process
GO:0030315	T-tubule	IEA	cellular component
GO:0031987	locomotion involved in locomotory behavior	IEA	biological process
GO:0033192	calmodulin-dependent protein phosphatase activity	IEA	molecular function
GO:0034097	response to cytokine	IEA	biological process
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	IEA	biological process
GO:0043029	T cell homeostasis	IEA	biological process
GO:0098978	glutamatergic synapse	IEA	cellular component
GO:0001915	negative regulation of T cell mediated cytotoxicity	IEA	biological process
GO:0004722	protein serine/threonine phosphatase activity	IEA	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0006468	protein phosphorylation	IEA	biological process
GO:0007507	heart development	IEA	biological process
GO:0010468	regulation of gene expression	IEA	biological process
GO:0030018	Z disc	IEA	cellular component
GO:0030217	T cell differentiation	IEA	biological process
GO:1900242	regulation of synaptic vesicle endocytosis	IEA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005955	calcineurin complex	IDA	cellular component
GO:0033173	calcineurin-NFAT signaling cascade	IDA	biological process
GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0006470	protein dephosphorylation	IDA	biological process
GO:0005516	calmodulin binding	IDA	molecular function
GO:0005955	calcineurin complex	IDA	cellular component
GO:0035690	cellular response to drug	IDA	biological process
GO:0005516	calmodulin binding	IDA	molecular function
GO:0033173	calcineurin-NFAT signaling cascade	IDA	biological process
GO:0008144	drug binding	IDA	molecular function
GO:0033192	calmodulin-dependent protein phosphatase activity	IDA	molecular function
GO:0033192	calmodulin-dependent protein phosphatase activity	IDA	molecular function
GO:0006470	protein dephosphorylation	IDA	biological process
GO:0030346	protein phosphatase 2B binding	IDA	molecular function
GO:0005955	calcineurin complex	IDA	cellular component
GO:0005516	calmodulin binding	IDA	molecular function
GO:0005509	calcium ion binding	IDA	molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0019899	enzyme binding	IDA	molecular function
GO:0048167	regulation of synaptic plasticity	TAS	biological process
GO:0045893	positive regulation of transcription, DNA-templated	NAS	biological process
GO:0042110	T cell activation	TAS	biological process
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISS	biological process
GO:0017156	calcium-ion regulated exocytosis	ISS	biological process
GO:0016311	dephosphorylation	TAS	biological process
GO:0007613	memory	TAS	biological process
GO:0007165	signal transduction	NAS	biological process
GO:0005516	calmodulin binding	NAS	molecular function
GO:0046983	protein dimerization activity	IPI	molecular function
GO:0005886	plasma membrane	ISS	cellular component
GO:0048675	axon extension	TAS	biological process
GO:0042098	T cell proliferation	NAS	biological process
GO:0033192	calmodulin-dependent protein phosphatase activity	TAS	molecular function
GO:0033192	calmodulin-dependent protein phosphatase activity	ISS	molecular function
GO:0006470	protein dephosphorylation	ISS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0050796	regulation of insulin secretion	ISS	biological process
GO:0007612	learning	TAS	biological process
GO:0006468	protein phosphorylation	ISS	biological process
GO:0004722	protein serine/threonine phosphatase activity	NAS	molecular function
GO:0033192	calmodulin-dependent protein phosphatase activity	IBA	molecular function
GO:0005955	calcineurin complex	IBA	cellular component
GO:0005516	calmodulin binding	IBA	molecular function
GO:0097720	calcineurin-mediated signaling	IBA	biological process
GO:0005737	cytoplasm	IBA	cellular component
GO:0016787	hydrolase activity	IEA	molecular function
GO:0033192	calmodulin-dependent protein phosphatase activity	IEA	molecular function
GO:0097720	calcineurin-mediated signaling	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa05010	Alzheimer disease
hsa04010	MAPK signaling pathway
hsa05166	Human T-cell leukemia virus 1 infection
hsa05163	Human cytomegalovirus infection
hsa04020	Calcium signaling pathway
hsa04360	Axon guidance
hsa05170	Human immunodeficiency virus 1 infection
hsa04310	Wnt signaling pathway
hsa04022	cGMP-PKG signaling pathway
hsa05167	Kaposi sarcoma-associated herpesvirus infection
hsa05152	Tuberculosis
hsa04921	Oxytocin signaling pathway
hsa04218	Cellular senescence
hsa04728	Dopaminergic synapse
hsa04724	Glutamatergic synapse
hsa04380	Osteoclast differentiation
hsa04114	Oocyte meiosis
hsa04922	Glucagon signaling pathway
hsa04650	Natural killer cell mediated cytotoxicity
hsa04625	C-type lectin receptor signaling pathway
hsa04660	T cell receptor signaling pathway
hsa04659	Th17 cell differentiation
hsa04662	B cell receptor signaling pathway
hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa04658	Th1 and Th2 cell differentiation
hsa04720	Long-term potentiation
hsa05031	Amphetamine addiction
hsa04924	Renin secretion
hsa05014	Amyotrophic lateral sclerosis
hsa04370	VEGF signaling pathway

Diseases

Associated diseases	References
focal segmental glomerulosclerosis	PMID:26436650
Aortic valve stenosis	PMID:15533858
Schizophrenia	PMID:15820226
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq