• Gene id: 55308

Gene Summary

• Gene Symbol: DDX19A   Gene   UCSC   Ensembl
• Aliases: DDX19-DDX19L, DDX19L
• Gene name: DEAD-box helicase 19A
• Alternate names: ATP-dependent RNA helicase DDX19A, DDX19-like protein, DEAD (Asp-Glu-Ala-As) box polypeptide 19A, DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A, DEAD box protein 19A, RNA helicase,
• Gene location: 16q22.1 (70346828: 70373382)     Exons: 12     NC_000016.10
• OMIM: 616388

Protein Summary

• Protein general information: Q9NUU7  
  • Name: ATP dependent RNA helicase DDX19A (EC 3.6.4.13) (DDX19 like protein) (DEAD box protein 19A)
  • Length: 478  
  • Mass: 53975
• Sequence:

  MATDSWALAVDEQEAAVKSMTNLQIKEEKVKADTNGIIKTSTTAEKTDEEEKEDRAAQSLLNKLIRSNLVDNTNQ
  VEVLQRDPNSPLYSVKSFEELRLKPQLLQGVYAMGFNRPSKIQENALPMMLAEPPQNLIAQSQSGTGKTAAFVLA
  MLSRVEPSDRYPQCLCLSPTYELALQTGKVIEQMGKFYPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDWCS
  KLKFIDPKKIKVFVLDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIKLKREE
  ETLDTIKQYYVLCSSRDEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSKEGHQVALLSGEMMVEQRAAVI
  ERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDNETYLHRIGRTGRFGKRGLAVNMVDSKHSMNI
  LNRIQEHFNKKIERLDTDDLDEIEKIAN

• Structural information:
  • Protein Domains: (124..29-)
    (/note="Helicase-ATP-binding)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00541-)
    (305..47-)
    (/note="Helicase-C-terminal)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00542"-)
  • Interpro: IPR011545  IPR014001  IPR001650  IPR027417  IPR014014  
  • Prosite: PS51192 PS51194 PS51195
  • STRING: ENSP00000306117
• Other Databases: GeneCards:  DDX19A  Malacards:  DDX19A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016973	poly(A)+ mRNA export from nucleus	IBA	biological process
GO:0010494	cytoplasmic stress granule	IBA	cellular component
GO:0005634	nucleus	IBA	cellular component
GO:0003724	RNA helicase activity	IBA	molecular function
GO:0003723	RNA binding	IBA	molecular function
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0004386	helicase activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005524	ATP binding	IEA	molecular function
GO:0003723	RNA binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0003724	RNA helicase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005654	nucleoplasm	IEA	cellular component
GO:0008150	biological_process	ND	biological process
GO:0003674	molecular_function	ND	molecular function
GO:0016020	membrane	HDA	cellular component

Diseases

Associated diseases	References
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray