• Gene id: 55301

Gene Summary

• Gene Symbol: OLAH   Gene   UCSC   Ensembl
• Aliases: AURA1, SAST, TE2, THEDC1
• Gene name: oleoyl-ACP hydrolase
• Alternate names: S-acyl fatty acid synthase thioesterase, medium chain, augmented in rheumatoid arthritis 1, oleoyl-acyl-carrier-protein hydrolase, thioesterase 2, thioesterase II, thioesterase domain containing 1, thioesterase domain-containing protein 1,
• Gene location: 10p13 (15032223: 15073852)     Exons: 11     NC_000010.11

Protein Summary

• Protein general information: Q9NV23  
  • Name: S acyl fatty acid synthase thioesterase, medium chain (EC 3.1.2.14) (Augmented in rheumatoid arthritis 1) (AURA1) (Oleoyl ACP hydrolase) (Thioesterase 2) (TE2) (Thioesterase II) (Thioesterase domain containing protein 1)
  • Length: 265  
  • Mass: 29931
  • Tissue specificity: Detected both in lactating and non-lactating breast epithelium (at protein level) (PubMed
• Sequence:

  MERGDQPKRTRNENIFNCLYKNPEATFKLICFPWMGGGSTHFAKWGQDTHDLLEVHSLRLPGRESRVEEPLENDI
  SQLVDEVVCALQPVIQDKPFAFFGHSMGSYIAFRTALGLKENNQPEPLHLFLSSATPVHSKAWHRIPKDDELSEE
  QISHYLMEFGGTPKHFAEAKEFVKQCSPIIRADLNIVRSCTSNVPSKAVLSCDLTCFVGSEDIAKDMEAWKDVTS
  GNAKIYQLPGGHFYLLDPANEKLIKNYIIKCLEVSSISNF

• Structural information:
  • Interpro: IPR029058  IPR012223  IPR001031  
  • PDB: 4XJV
  • PDBsum: 4XJV
• Other Databases: GeneCards:  OLAH  Malacards:  OLAH

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008610	lipid biosynthetic process	IBA	biological process
GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	IDA	molecular function
GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	IDA	molecular function
GO:0047381	dodecanoyl-[acyl-carrier-protein] hydrolase activity	IDA	molecular function
GO:0051792	medium-chain fatty acid biosynthetic process	IDA	biological process
GO:0005829	cytosol	ISS	cellular component
GO:0009058	biosynthetic process	IEA	biological process
GO:0016788	hydrolase activity, acting on ester bonds	IEA	molecular function
GO:0006633	fatty acid biosynthetic process	IEA	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0006629	lipid metabolic process	IEA	biological process
GO:0006631	fatty acid metabolic process	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	IEA	molecular function
GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	IEA	molecular function
GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	IEA	molecular function
GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	IEA	molecular function
GO:0005829	cytosol	IEA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00061	Fatty acid biosynthesis

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R