• Gene id: 55277

Gene Summary

• Gene Symbol: FGGY   Gene   UCSC   Ensembl
• Gene name: FGGY carbohydrate kinase domain containing
• Alternate names: FGGY carbohydrate kinase domain-containing protein, D-ribulokinase,
• Gene location: 1p32.1 (59296404: 59762729)     Exons: 30     NC_000001.11
• Gene summary(Entrez): This gene encodes a protein that phosphorylates carbohydrates such as ribulose, ribitol, and L-arabinitol. Genome-wide association studies in some populations have found an association between polymorphisms in this gene and sporadic amyotrophic lateral sc
• OMIM: 611370

Protein Summary

• Protein general information: Q96C11  
  • Name: FGGY carbohydrate kinase domain containing protein (EC 2.7.1. )
  • Length: 551  
  • Mass: 59993
  • Tissue specificity: Expressed in kidney, lung and small intestine and to a lower extent in liver and detected in cerebrospinal fluid (at protein level). {ECO
• Sequence:

  MSGGEQKPERYYVGVDVGTGSVRAALVDQSGVLLAFADQPIKNWEPQFNHHEQSSEDIWAACCVVTKKVVQGIDL
  NQIRGLGFDATCSLVVLDKQFHPLPVNQEGDSHRNVIMWLDHRAVSQVNRINETKHSVLQYVGGVMSVEMQAPKL
  LWLKENLREICWDKAGHFFDLPDFLSWKATGVTARSLCSLVCKWTYSAEKGWDDSFWKMIGLEDFVADNYSKIGN
  QVLPPGASLGNGLTPEAARDLGLLPGIAVAASLIDAHAGGLGVIGADVRGHGLICEGQPVTSRLAVICGTSSCHM
  GISKDPIFVPGVWGPYFSAMVPGFWLNEGGQSVTGKLIDHMVQGHAAFPELQVKATARCQSIYAYLNSHLDLIKK
  AQPVGFLTVDLHVWPDFHGNRSPLADLTLKGMVTGLKLSQDLDDLAILYLATVQAIALGTRFIIEAMEAAGHSIS
  TLFLCGGLSKNPLFVQMHADITGMPVVLSQEVESVLVGAAVLGACASGDFASVQEAMAKMSKVGKVVFPRLQDKK
  YYDKKYQVFLKLVEHQKEYLAIMNDD

• Structural information:
  • Interpro: IPR000577  IPR018485  IPR018484  IPR006003  
  • CDD: cd07782
  • STRING: ENSP00000360262
• Other Databases: GeneCards:  FGGY  Malacards:  FGGY

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005975	carbohydrate metabolic process	IEA	biological process
GO:0016773	phosphotransferase activity, alcohol group as acceptor	IEA	molecular function
GO:0016301	kinase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0019150	D-ribulokinase activity	IDA	molecular function
GO:0019321	pentose metabolic process	IDA	biological process
GO:0019321	pentose metabolic process	IMP	biological process
GO:0046835	carbohydrate phosphorylation	IDA	biological process
GO:0070050	neuron cellular homeostasis	IMP	biological process
GO:0005575	cellular_component	ND	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray