• Gene id: 55270

Gene Summary

• Gene Symbol: NUDT15   Gene   UCSC   Ensembl
• Aliases: MTH2, NUDT15D
• Gene name: nudix hydrolase 15
• Alternate names: nucleotide triphosphate diphosphatase NUDT15, 8-oxo-dGTPase NUDT15, mutT homolog 2, nucleoside diphosphate-linked to another moiety X hydrolase 15, nudix (nucleoside diphosphate linked moiety X)-type motif 15, probable 7,8-dihydro-8-oxoguanine triphosphatase N,
• Gene location: 13q14.2 (48037566: 48052741)     Exons: 5     NC_000013.11
• Gene summary(Entrez): This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base
• OMIM: 615792

Protein Summary

• Protein general information: Q9NV35  
  • Name: Nucleotide triphosphate diphosphatase NUDT15 (EC 3.6.1.9) (MutT homolog 2) (MTH2) (Nucleoside diphosphate linked moiety X motif 15) (Nudix motif 15) (Nucleoside diphosphate linked to another moiety X hydrolase 15) (Nudix hydrolase 15)
  • Length: 164  
  • Mass: 18609
• Sequence:

  MTASAQPRGRRPGVGVGVVVTSCKHPRCVLLGKRKGSVGAGSFQLPGGHLEFGETWEECAQRETWEEAALHLKNV
  HFASVVNSFIEKENYHYVTILMKGEVDVTHDSEPKNVEPEKNESWEWVPWEELPPLDQLFWGLRCLKEQGYDPFK
  EDLNHLVGYKGNHL

• Structural information:
  • Protein Domains: (9..14-)
    (/note="Nudix-hydrolase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00794"-)
  • Interpro: IPR015797  IPR000086  
  • Prosite: PS51462
  • PDB: 5BON 5LPG
  • PDBsum: 5BON 5LPG
  • STRING: ENSP00000258662
• Other Databases: GeneCards:  NUDT15  Malacards:  NUDT15

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0035539	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	IBA	molecular function
GO:0006203	dGTP catabolic process	IBA	biological process
GO:0005829	cytosol	IBA	cellular component
GO:1901292	nucleoside phosphate catabolic process	IDA	biological process
GO:0047429	nucleoside-triphosphate diphosphatase activity	IDA	molecular function
GO:0035539	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	IDA	molecular function
GO:0006203	dGTP catabolic process	IDA	biological process
GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	IDA	molecular function
GO:1901292	nucleoside phosphate catabolic process	IMP	biological process
GO:0000278	mitotic cell cycle	IMP	biological process
GO:0042738	exogenous drug catabolic process	IMP	biological process
GO:0006195	purine nucleotide catabolic process	IMP	biological process
GO:0042262	DNA protection	IMP	biological process
GO:0061136	regulation of proteasomal protein catabolic process	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0042262	DNA protection	IMP	NOT|biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0004551	nucleotide diphosphatase activity	IEA	molecular function
GO:0047429	nucleoside-triphosphate diphosphatase activity	IEA	molecular function
GO:0036218	dTTP diphosphatase activity	IEA	molecular function
GO:0035529	NADH pyrophosphatase activity	IEA	molecular function
GO:0017110	nucleoside-diphosphatase activity	EXP	molecular function
GO:0035539	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	EXP	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0034656	nucleobase-containing small molecule catabolic process	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0000302	response to reactive oxygen species	IEA	biological process
GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	IEA	molecular function
GO:0009217	purine deoxyribonucleoside triphosphate catabolic process	IEA	biological process

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray