• Gene id: 5522

Gene Summary

• Gene Symbol: PPP2R2C   Gene   UCSC   Ensembl
• Aliases: B55-GAMMA, B55gamma, IMYPNO, IMYPNO1, PR52, PR55G
• Gene name: protein phosphatase 2 regulatory subunit Bgamma
• Alternate names: protein phosphatase 2, regulatory subunit B, gamma, PP2A, subunit B, B-gamma isoform, PP2A, subunit B, B55-gamma isoform, PP2A, subunit B, PR55-gamma isoform, PP2A, subunit B, R2-gamma isoform, gamma isoform of regulatory subunit B55, protein phosphatase 2, pho,
• Gene location: 4p16.1 (75391069: 75432687)     Exons: 8     NC_000012.12
• Gene summary(Entrez): The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heter
• OMIM: 605997

Protein Summary

• Protein general information: Q9Y2T4  
  • Name: Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (IMYPNO1) (PP2A subunit B isoform B55 gamma) (PP2A subunit B isoform PR55 gamma) (PP2A subunit B isoform R2 gamma) (PP2A subunit B isoform gamma)
  • Length: 447  
  • Mass: 51515
• Sequence:

  MGEDTDTRKINHSFLRDHSYVTEADIISTVEFNHTGELLATGDKGGRVVIFQREPESKNAPHSQGEYDVYSTFQS
  HEPEFDYLKSLEIEEKINKIKWLPQQNAAHSLLSTNDKTIKLWKITERDKRPEGYNLKDEEGKLKDLSTVTSLQV
  PVLKPMDLMVEVSPRRIFANGHTYHINSISVNSDCETYMSADDLRINLWHLAITDRSFNIVDIKPANMEDLTEVI
  TASEFHPHHCNLFVYSSSKGSLRLCDMRAAALCDKHSKLFEEPEDPSNRSFFSEIISSVSDVKFSHSGRYMLTRD
  YLTVKVWDLNMEARPIETYQVHDYLRSKLCSLYENDCIFDKFECAWNGSDSVIMTGAYNNFFRMFDRNTKRDVTL
  EASRESSKPRAVLKPRRVCVGGKRRRDDISVDSLDFTKKILHTAWHPAENIIAIAATNNLYIFQDKVNSDMH

• Structural information:
  • Interpro: IPR000009  IPR018067  IPR015943  IPR001680  IPR036322  
  • Prosite: PS01024 PS01025
  • STRING: ENSP00000335083
• Other Databases: GeneCards:  PPP2R2C  Malacards:  PPP2R2C

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0043666	regulation of phosphoprotein phosphatase activity	IEA	biological process
GO:0043666	regulation of phosphoprotein phosphatase activity	IEA	biological process
GO:0043666	regulation of phosphoprotein phosphatase activity	IEA	biological process
GO:0019888	protein phosphatase regulator activity	NAS	molecular function
GO:0000159	protein phosphatase type 2A complex	NAS	cellular component
GO:0070262	peptidyl-serine dephosphorylation	IBA	biological process
GO:0005829	cytosol	IBA	cellular component
GO:0019888	protein phosphatase regulator activity	IBA	molecular function
GO:0000159	protein phosphatase type 2A complex	IBA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0000159	protein phosphatase type 2A complex	IEA	cellular component
GO:0019888	protein phosphatase regulator activity	IEA	molecular function

KEGG pathways

Pathway id	Pathway name
hsa04151	PI3K-Akt signaling pathway
hsa05165	Human papillomavirus infection
hsa04530	Tight junction
hsa04390	Hippo signaling pathway
hsa04261	Adrenergic signaling in cardiomyocytes
hsa04728	Dopaminergic synapse
hsa05160	Hepatitis C
hsa04071	Sphingolipid signaling pathway
hsa04152	AMPK signaling pathway
hsa03015	mRNA surveillance pathway
hsa05142	Chagas disease

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray