• Gene id: 55203

Gene Summary

• Gene Symbol: LGI2   Gene   UCSC   Ensembl
• Aliases: LGIL2
• Gene name: leucine rich repeat LGI family member 2
• Alternate names: leucine-rich repeat LGI family member 2, LGI1-like protein 2, leucine-rich glioma-inactivated protein 2, leucine-rich, glioma inactivated 2,
• Gene location: 4p15.2 (25030945: 24991959)     Exons: 10     NC_000004.12
• OMIM: 603020

Protein Summary

• Protein general information: Q8N0V4  
  • Name: Leucine rich repeat LGI family member 2 (LGI1 like protein 2) (Leucine rich glioma inactivated protein 2)
  • Length: 545  
  • Mass: 62298
  • Tissue specificity: Brain, heart and placenta. {ECO
• Sequence:

  MALRRGGCGALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIICVGSSWVPRIVPGDISSLSLVNGTFSE
  IKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPR
  DVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQT
  LPYQSVSVDTFNSKNDVYVAIAQPSMENCMVLEWDHIEMNFRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGS
  HIYKYDESWTKFVKFQDIEVSRISKPNDIELFQIDDETFFVIADSSKAGLSTVYKWNSKGFYSYQSLHEWFRDTD
  AEFVDIDGKSHLILSSRSQVPIILQWNKSSKKFVPHGDIPNMEDVLAVKSFRMQNTLYLSLTRFIGDSRVMRWNS
  KQFVEIQALPSRGAMTLQPFSFKDNHYLALGSDYTFSQIYQWDKEKQLFKKFKEIYVQAPRSFTAVSTDRRDFFF
  ASSFKGKTKIFEHIIVDLSL

• Structural information:
  • Protein Domains: (29..6-)
    (/note="LRRNT-)
    (167..21-)
    (/note="LRRCT"-)
  • Interpro: IPR000483  IPR009039  IPR005492  IPR001611  IPR003591   IPR032675  
  • Prosite: PS50912
  • STRING: ENSP00000371548
• Other Databases: GeneCards:  LGI2  Malacards:  LGI2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:1904862	inhibitory synapse assembly	ISS	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:1904862	inhibitory synapse assembly	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq