• Gene id: 55167

Gene Summary

• Gene Symbol: MSL2   Gene   UCSC   Ensembl
• Aliases: MSL-2, MSL2L1, RNF184
• Gene name: MSL complex subunit 2
• Alternate names: E3 ubiquitin-protein ligase MSL2, E3 ubiquitin-protein transferase MSL2, MSL2-like 1, male-specific lethal 2 homolog, male-specific lethal 2-like 1, male-specific lethal-2 homolog 1, ring finger protein 184,
• Gene location: 3q22.3 (136197299: 136148916)     Exons: 5     NC_000003.12

Protein Summary

• Protein general information: Q9HCI7  
  • Name: E3 ubiquitin protein ligase MSL2 (EC 2.3.2. ) (E3 ubiquitin protein transferase MSL2) (Male specific lethal 2 like 1) (MSL2 like 1) (Male specific lethal 2 homolog) (MSL 2) (Male specific lethal 2 homolog 1) (RING finger protein 184)
  • Length: 577  
  • Mass: 62541
• Sequence:

  MNPVNATALYISASRLVLNYDPGDPKAFTEINRLLPYFRQSLSCCVCGHLLQDPIAPTNSTCQHYVCKTCKGKKM
  MMKPSCSWCKDYEQFEENKQLSILVNCYKKLCEYITQTTLARDIIEAVDCSSDILALLNDGSLFCEETEKPSDSS
  FTLCLTHSPLPSTSEPTTDPQASLSPMSESTLSIAIGSSVINGLPTYNGLSIDRFGINIPSPEHSNTIDVCNTVD
  IKTEDLSDSLPPVCDTVATDLCSTGIDICSFSEDIKPGDSLLLSVEEVLRSLETVSNTEVCCPNLQPNLEATVSN
  GPFLQLSSQSLSHNVFMSTSPALHGLSCTAATPKIAKLNRKRSRSESDSEKVQPLPISTIIRGPTLGASAPVTVK
  RESKISLQPIATVPNGGTTPKISKTVLLSTKSMKKSHEHGSKKSHSKTKPGILKKDKAVKEKIPSHHFMPGSPTK
  TVYKKPQEKKGCKCGRATQNPSVLTCRGQRCPCYSNRKACLDCICRGCQNSYMANGEKKLEAFAVPEKALEQTRL
  TLGINVTSIAVRNASTSTSVINVTGSPVTTFLAASTHDDKSLDEAIDMRFDC

• Structural information:
  • Interpro: IPR037922  IPR032049  IPR032043  IPR033467  IPR001841   IPR013083  
  • Prosite: PS50089
  • CDD: cd13122
  • PDB: 4B7Y 4B86
  • PDBsum: 4B7Y 4B86
  • STRING: ENSP00000311827
• Other Databases: GeneCards:  MSL2  Malacards:  MSL2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0061630	ubiquitin protein ligase activity	IBA	molecular function
GO:0072487	MSL complex	IBA	cellular component
GO:0043984	histone H4-K16 acetylation	IBA	biological process
GO:0016567	protein ubiquitination	IBA	biological process
GO:0072487	MSL complex	IDA	cellular component
GO:0043984	histone H4-K16 acetylation	IDA	biological process
GO:0061630	ubiquitin protein ligase activity	IEA	molecular function
GO:0072487	MSL complex	IEA	cellular component
GO:0016740	transferase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0005654	nucleoplasm	TAS	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq