• Gene id: 5516

Gene Summary

• Gene Symbol: PPP2CB   Gene   UCSC   Ensembl
• Aliases: PP2Abeta, PP2CB
• Gene name: protein phosphatase 2 catalytic subunit beta
• Alternate names: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform, PP2A-beta, protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform, protein phosphatase 2, catalytic subunit, beta isoform, protein phosphatase 2, catalytic subunit, beta iso,
• Gene location: 8p12 (30812817: 30785615)     Exons: 7     NC_000020.11
• Gene summary(Entrez): This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which
• OMIM: 176916

Protein Summary

Gene ontology

GO accession	Term name	Evidence code	Go category

KEGG pathways

Pathway id	Pathway name
hsa04071	Sphingolipid signaling pathway
hsa04151	PI3K-Akt signaling pathway
hsa04152	AMPK signaling pathway
hsa04140	Autophagy - animal
hsa04136	Autophagy - other
hsa04114	Oocyte meiosis
hsa04530	Tight junction
hsa04261	Adrenergic signaling in cardiomyocytes
hsa04728	Dopaminergic synapse
hsa04730	Long-term depression
hsa05160	Hepatitis C
hsa05165	Human papillomavirus infection
hsa05142	Chagas disease
hsa04151	PI3K-Akt signaling pathway
hsa04728	Dopaminergic synapse
hsa04261	Adrenergic signaling in cardiomyocytes
hsa04152	AMPK signaling pathway
hsa05165	Human papillomavirus infection
hsa04390	Hippo signaling pathway
hsa04071	Sphingolipid signaling pathway
hsa04114	Oocyte meiosis
hsa04530	Tight junction
hsa04140	Autophagy - animal
hsa03015	mRNA surveillance pathway
hsa04350	TGF-beta signaling pathway
hsa05160	Hepatitis C
hsa04730	Long-term depression
hsa05142	Chagas disease
hsa04136	Autophagy - other

Diseases

Associated diseases	References
May play important role in spermatogenesis	MIK: 2168171
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
May play important role in spermatogenesis	MIK: 2168171
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
2168171	May play important role in spermatogenesis				Male infertility
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881