• Gene id: 55130

Gene Summary

• Gene Symbol: ARMC4   Gene   UCSC   Ensembl
• Aliases: CILD23, gudu
• Gene name: armadillo repeat containing 4
• Alternate names: armadillo repeat-containing protein 4, testis tissue sperm-binding protein Li 74n,
• Gene location: 10p12.1 (27999499: 27812165)     Exons: 30     NC_000010.11
• Gene summary(Entrez): The protein encoded by this gene contains ten Armadillo repeat motifs (ARMs) and one HEAT repeat, and is thought to be involved in ciliary and flagellar movement. This protein has been shown to localize to the ciliary axonemes and at the ciliary base of r
• OMIM: 615408

Protein Summary

• Protein general information: Q5T2S8  
  • Name: Armadillo repeat containing protein 4
  • Length: 1044  
  • Mass: 115679
  • Tissue specificity: Expressed in respiratory epithelial cells (at protein level). {ECO
• Sequence:

  MGVALRKLTQWTAAGHGTGILEITPLNEAILKEIIVFVESFIYKHPQEAKFVFVEPLEWNTSLAPSAFESGYVVS
  ETTVKSEEVDKNGQPLLFLSVPQIKIRSFGQLSRLLLIAKTGKLKEAQACVEANRDPIVKILGSDYNTMKENSIA
  LNILGKITRDDDPESEIKMKIAMLLKQLDLHLLNHSLKHISLEISLSPMTVKKDIELLKRFSGKGNQTVLESIEY
  TSDYEFSNGCRAPPWRQIRGEICYVLVKPHDGETLCITCSAGGVFLNGGKTDDEGDVNYERKGSIYKNLVTFLRE
  KSPKFSENMSKLGISFSEDQQKEKDQLGKAPKKEEAAALRKDISGSDKRSLEKNQINFWRNQMTKRWEPSLNWKT
  TVNYKGKGSAKEIQEDKHTGKLEKPRPSVSHGRAQLLRKSAEKIEETVSDSSSESEEDEEPPDHRQEASADLPSE
  YWQIQKLVKYLKGGNQTATVIALCSMRDFSLAQETCQLAIRDVGGLEVLINLLETDEVKCKIGSLKILKEISHNP
  QIRQNIVDLGGLPIMVNILDSPHKSLKCLAAETIANVAKFKRARRVVRQHGGITKLVALLDCAHDSTKPAQSSLY
  EARDVEVARCGALALWSCSKSHTNKEAIRKAGGIPLLARLLKTSHENMLIPVVGTLQECASEENYRAAIKAERII
  ENLVKNLNSENEQLQEHCAMAIYQCAEDKETRDLVRLHGGLKPLASLLNNTDNKERLAAVTGAIWKCSISKENVT
  KFREYKAIETLVGLLTDQPEEVLVNVVGALGECCQERENRVIVRKCGGIQPLVNLLVGINQALLVNVTKAVGACA
  VEPESMMIIDRLDGVRLLWSLLKNPHPDVKASAAWALCPCIKNAKDAGEMVRSFVGGLELIVNLLKSDNKEVLAS
  VCAAITNIAKDQENLAVITDHGVVPLLSKLANTNNNKLRHHLAEAISRCCMWGRNRVAFGEHKAVAPLVRYLKSN
  DTNVHRATAQALYQLSEDADNCITMHENGAVKLLLDMVGSPDQDLQEAAAGCISNIRRLALATEKARYT

• Structural information:
  • Interpro: IPR011989  IPR016024  IPR000225  
  • Prosite: PS50176
  • STRING: ENSP00000306410
• Other Databases: GeneCards:  ARMC4  Malacards:  ARMC4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003356	regulation of cilium beat frequency	IMP	biological process
GO:0036158	outer dynein arm assembly	IMP	biological process
GO:0036158	outer dynein arm assembly	IMP	biological process
GO:0005930	axoneme	IDA	cellular component
GO:0003341	cilium movement	IMP	biological process
GO:0007368	determination of left/right symmetry	IMP	biological process
GO:0003341	cilium movement	IMP	biological process
GO:0042995	cell projection	IEA	cellular component
GO:0030030	cell projection organization	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005929	cilium	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0097546	ciliary base	IDA	cellular component
GO:0005930	axoneme	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0036158	outer dynein arm assembly	IEA	biological process
GO:0003341	cilium movement	IEA	biological process
GO:0007368	determination of left/right symmetry	IEA	biological process
GO:0007507	heart development	IEA	biological process
GO:0021591	ventricular system development	IEA	biological process

Diseases

Associated diseases	References
Primary ciliary dyskinesia	KEGG:H00564
Primary ciliary dyskinesia	KEGG:H00564
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R