• Gene id: 55090

Gene Summary

• Gene Symbol: MED9   Gene   UCSC   Ensembl
• Aliases: MED25
• Gene name: mediator complex subunit 9
• Alternate names: mediator of RNA polymerase II transcription subunit 9, mediator of RNA polymerase II transcription, subunit 9 homolog, mediator subunit 25,
• Gene location: 17p11.2 (17476999: 17493220)     Exons: 2     NC_000017.11
• Gene summary(Entrez): The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located wit
• OMIM: 165380

Protein Summary

• Protein general information: Q9NWA0  
  • Name: Mediator of RNA polymerase II transcription subunit 9 (Mediator complex subunit 9)
  • Length: 146  
  • Mass: 16403
• Sequence:

  MASAGVAAGRQAEDVLPPTSDQPLPDTKPLPPPQPPPVPAPQPQQSPAPRPQSPARAREEENYSFLPLVHNIIKC
  MDKDSPEVHQDLNALKSKFQEMRKLISTMPGIHLSPEQQQQQLQSLREQVRTKNELLQKYKSLCMFEIPKE

• Structural information:
  • Interpro: IPR037212  IPR011425  IPR039242  
  • STRING: ENSP00000268711
• Other Databases: GeneCards:  MED9  Malacards:  MED9

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016592	mediator complex	IBA	cellular component
GO:0006357	regulation of transcription by RNA polymerase II	IEA	biological process
GO:0016592	mediator complex	IEA	cellular component
GO:0003712	transcription coregulator activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0016592	mediator complex	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq