• Gene id: 55014

Gene Summary

• Gene Symbol: STX17   Gene   UCSC   Ensembl
• Gene name: syntaxin 17
• Alternate names: syntaxin-17,
• Gene location: 9q31.1 (99906653: 99974540)     Exons: 12     NC_000009.12
• OMIM: 604204

Protein Summary

• Protein general information: P56962  
  • Name: Syntaxin 17
  • Length: 302  
  • Mass: 33403
• Sequence:

  MSEDEEKVKLRRLEPAIQKFIKIVIPTDLERLRKHQINIEKYQRCRIWDKLHEEHINAGRTVQQLRSNIREIEKL
  CLKVRKDDLVLLKRMIDPVKEEASAATAEFLQLHLESVEELKKQFNDEETLLQPPLTRSMTVGGAFHTTEAEASS
  QSLTQIYALPEIPQDQNAAESWETLEADLIELSQLVTDFSLLVNSQQEKIDSIADHVNSAAVNVEEGTKNLGKAA
  KYKLAALPVAGALIGGMVGGPIGLLAGFKVAGIAAALGGGVLGFTGGKLIQRKKQKMMEKLTSSCPDLPSQTDKK
  CS

• Structural information:
  • Protein Domains: (162..22-)
    homology (/note="t-SNARE-coiled-coil)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00202"-)
  • Interpro: IPR010989  IPR028676  IPR006012  IPR000727  
  • Prosite: PS00914 PS50192
  • PDB: 4WY4
  • PDBsum: 4WY4
  • DIP: 47297
  • STRING: ENSP00000259400
• Other Databases: GeneCards:  STX17  Malacards:  STX17

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0048278	vesicle docking	IBA	biological process
GO:0031201	SNARE complex	IBA	cellular component
GO:0012505	endomembrane system	IBA	cellular component
GO:0006906	vesicle fusion	IBA	biological process
GO:0016021	integral component of membrane	IBA	cellular component
GO:0006886	intracellular protein transport	IBA	biological process
GO:0005484	SNAP receptor activity	IBA	molecular function
GO:0000421	autophagosome membrane	IBA	cellular component
GO:0000149	SNARE binding	IBA	molecular function
GO:0031201	SNARE complex	IDA	cellular component
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	IDA	cellular component
GO:0005791	rough endoplasmic reticulum	IDA	NOT|cellular component
GO:0005789	endoplasmic reticulum membrane	IDA	cellular component
GO:0005765	lysosomal membrane	IDA	NOT|cellular component
GO:0005739	mitochondrion	IDA	NOT|cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0000421	autophagosome membrane	IDA	cellular component
GO:0000149	SNARE binding	IDA	molecular function
GO:0000421	autophagosome membrane	IDA	cellular component
GO:0030897	HOPS complex	IDA	colocalizes with
GO:0097352	autophagosome maturation	IDA	biological process
GO:0000421	autophagosome membrane	IDA	cellular component
GO:0097111	endoplasmic reticulum-Golgi intermediate compartment organization	IMP	biological process
GO:0030868	smooth endoplasmic reticulum membrane	ISS	cellular component
GO:0005829	cytosol	ISS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0030134	COPII-coated ER to Golgi transport vesicle	ISS	cellular component
GO:0019903	protein phosphatase binding	IPI	molecular function
GO:0007030	Golgi organization	IMP	biological process
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	IMP	biological process
GO:0005484	SNAP receptor activity	IMP	molecular function
GO:0097352	autophagosome maturation	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0097352	autophagosome maturation	IMP	biological process
GO:0016192	vesicle-mediated transport	IEA	biological process
GO:0097111	endoplasmic reticulum-Golgi intermediate compartment organization	IEA	biological process
GO:0000149	SNARE binding	IEA	molecular function
GO:0005484	SNAP receptor activity	IEA	molecular function
GO:0006886	intracellular protein transport	IEA	biological process
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0097352	autophagosome maturation	IEA	biological process
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0031410	cytoplasmic vesicle	IEA	cellular component
GO:0016192	vesicle-mediated transport	IEA	biological process
GO:0006914	autophagy	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0034497	protein localization to phagophore assembly site	IDA	biological process
GO:0044233	mitochondria-associated endoplasmic reticulum membrane	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	IEA	cellular component
GO:0005829	cytosol	IEA	cellular component
GO:0030868	smooth endoplasmic reticulum membrane	IEA	cellular component
GO:0000149	SNARE binding	IEA	molecular function
GO:0019901	protein kinase binding	IEA	molecular function
GO:0030134	COPII-coated ER to Golgi transport vesicle	IEA	cellular component
GO:0005776	autophagosome	IEA	cellular component
GO:0000421	autophagosome membrane	IEA	cellular component
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	IEA	cellular component
GO:0030868	smooth endoplasmic reticulum membrane	IEA	cellular component
GO:0005789	endoplasmic reticulum membrane	IEA	cellular component
GO:0012507	ER to Golgi transport vesicle membrane	IEA	cellular component
GO:0005829	cytosol	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005776	autophagosome	IDA	cellular component
GO:0016240	autophagosome membrane docking	IDA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04140	Autophagy - animal
hsa04130	SNARE interactions in vesicular transport

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881