|
Gene id |
5501 |
| Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
PPP1CC Gene UCSC Ensembl |
|
Aliases |
PP-1G, PP1C, PPP1G |
|
Gene name |
protein phosphatase 1 catalytic subunit gamma |
|
Alternate names |
serine/threonine-protein phosphatase PP1-gamma catalytic subunit, protein phosphatase 1, catalytic subunit, gamma isoform, protein phosphatase 1, catalytic subunit, gamma isozyme, protein phosphatase 1C catalytic subunit, serine/threonine phosphatase 1 gamma, |
|
Gene location |
12q24.11 (110742913: 110708368) Exons: 10 NC_000012.12
|
|
Gene summary(Entrez) |
The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three close
|
|
OMIM |
176914 |
Protein Summary
|
|
| GO accession | Term name | Evidence code | Go category |
|---|
|
|
|
|
|
| Associated diseases |
References |
| Azoospermia | GAD: 19369647 |
| Oligozoospermia | GAD: 19369647 |
| May play important role in spermatogenesis | MIK: 2168171 |
| Leads to impaired spermatogenesis associated with defects in chromatin condensation and acrosome development | MIK: 20385779 |
| Required for male fertility | MIK: 23082183 |
| Spermatogenesis defects | MIK: 25605614 |
| Hypospermatogenesis | MIK: 28361989 |
| Important for regulation of normal spermatogenesis as well as spermatozoa capacitation and motility | MIK: 25605614 |
| Leads to impaired spermatogenesis associated with defects in chromatin condensation and acrosome development | MIK: 20385779 |
| Required for male fertility | MIK: 23082183 |
| Teratozoospermia | MIK: 17327269 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 20618881 |
Associated
with sper
matogenesi
s
|
|
|
|
Male infertility |
|
Show abstract |
| 20385779 |
Leads to i
mpaired sp
ermatogene
sis associ
ated with
defects in
chromatin
condensat
ion and ac
rosome dev
elopment
|
|
|
|
Male infertility |
|
Show abstract |
| 2168171 |
May play i
mportant r
ole in spe
rmatogenes
is
|
|
|
|
Male infertility |
|
Show abstract |
| 25605614 |
Important
for regula
tion of no
rmal sperm
atogenesis
as well a
s spermato
zoa capaci
tation and
motility
|
|
|
|
Male infertility |
|
Show abstract |
| 23082183 |
Required f
or male fe
rtility
|
|
|
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 28361989 |
Hyposperma
togenesis
|
|
|
6 (3 controls,
3 Klienfelter s
yndrome
|
Male infertility |
Microarray
|
Show abstract |
| 31037746 |
Spermatoge
nic defect
s
|
|
|
16 (1 control,
15 cases)
|
Male infertility |
GSE6023 analyzed using GEO2R
|
Show abstract |
|