• Gene id: 55006

Gene Summary

• Gene Symbol: TRMT61B   Gene   UCSC   Ensembl
• Gene name: tRNA methyltransferase 61B
• Alternate names: tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial, mRNA methyladenosine-N(1)-methyltransferase, potential tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61B, potential tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61B, t,
• Gene location: 2p23.2 (28870359: 28849820)     Exons: 8     NC_000002.12
• OMIM: 0

Protein Summary

• Protein general information: Q9BVS5  
  • Name: tRNA (adenine(58) N(1)) methyltransferase, mitochondrial (EC 2.1.1.220) (mRNA methyladenosine N(1) methyltransferase) (EC 2.1.1. )
  • Length: 477  
  • Mass: 52965
• Sequence:

  MLMAWCRGPVLLCLRQGLGTNSFLHGLGQEPFEGARSLCCRSSPRDLRDGEREHEAAQRKAPGAESCPSLPLSIS
  DIGTGCLSSLENLRLPTLREESSPRELEDSSGDQGRCGPTHQGSEDPSMLSQAQSATEVEERHVSPSCSTSRERP
  FQAGELILAETGEGETKFKKLFRLNNFGLLNSNWGAVPFGKIVGKFPGQILRSSFGKQYMLRRPALEDYVVLMKR
  GTAITFPKDINMILSMMDINPGDTVLEAGSGSGGMSLFLSKAVGSQGRVISFEVRKDHHDLAKKNYKHWRDSWKL
  SHVEEWPDNVDFIHKDISGATEDIKSLTFDAVALDMLNPHVTLPVFYPHLKHGGVCAVYVVNITQVIELLDGIRT
  CELALSCEKISEVIVRDWLVCLAKQKNGILAQKVESKINTDVQLDSQEKIGVKGELFQEDDHEESHSDFPYGSFP
  YVARPVHWQPGHTAFLVKLRKVKPQLN

• Structural information:
  • Interpro: IPR029063  IPR014816  
  • Prosite: PS51620
  • PDB: 2B25
  • PDBsum: 2B25
  • STRING: ENSP00000302801
• Other Databases: GeneCards:  TRMT61B  Malacards:  TRMT61B

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005739	mitochondrion	IBA	cellular component
GO:0070901	mitochondrial tRNA methylation	IBA	biological process
GO:0030488	tRNA methylation	IBA	biological process
GO:0031515	tRNA (m1A) methyltransferase complex	IBA	cellular component
GO:0061953	mRNA (adenine-N1-)-methyltransferase activity	IDA	molecular function
GO:0016429	tRNA (adenine-N1-)-methyltransferase activity	IDA	molecular function
GO:0080009	mRNA methylation	IDA	biological process
GO:0070901	mitochondrial tRNA methylation	IDA	biological process
GO:0051260	protein homooligomerization	IDA	biological process
GO:0005739	mitochondrion	IDA	cellular component
GO:0016433	rRNA (adenine) methyltransferase activity	IMP	molecular function
GO:0016429	tRNA (adenine-N1-)-methyltransferase activity	IEA	molecular function
GO:0030488	tRNA methylation	IEA	biological process
GO:0031515	tRNA (m1A) methyltransferase complex	IEA	cellular component
GO:0016740	transferase activity	IEA	molecular function
GO:0008033	tRNA processing	IEA	biological process
GO:0032259	methylation	IEA	biological process
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0005759	mitochondrial matrix	TAS	cellular component
GO:0070901	mitochondrial tRNA methylation	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0031167	rRNA methylation	IEA	biological process

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881